Melampomagnolide B derivatives
The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB. These derivatives are useful for treating cancer in humans.
1. A compound comprising Formula (I):
wherein:
R is selected from the group consisting of
wherein:
R 1 is selected from the group consisting of substituted indoles, substituted heterocyclic aromatic, and substituted aromatic derivatives;
R 2 is selected from the group consisting of substituted indoles; and
R 3 is selected from the group consisting of substituted amines.
2. The compound of claim 1 , wherein Formula (I) comprises:
wherein:
X is selected from the group consisting of S, O, NH, NR 10 ;
R 9 is selected from the group consisting of OMe, Cl, Br and F; and
R 10 is selected from the group consisting of H, CH 3 , benzyl, substituted benzyl, benzoyl, substituted benzoyl, and benzylsulfonyl and substituted benzylsulfonyl.
3. The compound of claim 1 , wherein Formula (I) comprises:
wherein:
R 11 is selected from the group consisting of H, CH 3 , benzyl, substituted benzyl, benzoyl, substituted benzoyl, and benzylsulfonyl and substituted benzylsulfonyl; and
R 12 and R 13 are independently selected from the group consisting of H, F, Cl, Br, OCH 3 , CN, CH 3 , NO 2 and COOCH 3 .
4. The compound of claim 1 , wherein Formula (I) comprises:
wherein:
R 14 is selected from the group consisting of 2-thiophenyl, 3-thiophenyl, 2-pyrazine, 3-pyrazine, 2-amino nicotinic acid, indole-3-acetic acid, indole-3-acrylic acid.
5. The compound of claim 1 , wherein Formula (I) comprises:
wherein:
R 15 is selected from the group consisting of:
6. The compound of claim 1 , wherein Formula (I) comprises:
wherein:
R 1 is selected from the group consisting of substituted indoles, substituted heterocyclic aromatic, aromatic and aliphatic derivatives.
7. A pharmaceutically acceptable salt comprising a compound of claim 1 .