Wound dressing materials
View Patent ↗A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressings comprising the materials, methods of treatment with the materials, and methods of making the materials.
1. A wound dressing, comprising:
an active layer comprising a wound-facing side, N-acetyl cysteine or a salt thereof, and a stabilized ascorbate, wherein a weight ratio of N-acetyl cysteine or a salt thereof to the stabilized ascorbate is from about 1:4 to about 4:1;
a backing sheet extending over the active layer opposite to the wound facing side; and
a moisture-vapor transmitting adhesive layer disposed between the backing sheet and the active layer;
wherein the stabilized ascorbate comprises a member selected from the group consisting of ascorbate 2-phosphate or polyphosphate compounds, trisodium L-ascorbyl-2-monophosphate, 2-phospho-L-ascorbic acid trisodium salt, magnesium ascorbyl phosphate (MAP), L-ascorbic acid mono(dihydrogen phosphate) magnesium salt, magnesium L-ascorbic acid-2-phosphate, trisodium L-ascorbyl-2-polyphosphate, and a combination of any two or more thereof.
2. The wound dressing of claim 1 , further comprising an absorbent layer positioned between the active layer and the backing sheet.
3. The wound dressing of claim 1 , wherein the active layer further comprises a carrier material.
4. The wound dressing of claim 3 , wherein the carrier material is bioabsorbable and adapted to provide sustainable release of N-acetyl cysteine or a salt thereof and the stabilized ascorbate.
5. The wound dressing of claim 3 , wherein the carrier material consists essentially of a freeze-dried sponge or a solvent-dried sponge.
6. The wound dressing of claim 5 , wherein the carrier material comprises oxidized cellulose, in combination with collagen or chitosan.
7. The wound dressing of claim 1 , further comprising a liquid-permeable top sheet disposed on the wound facing side of the active layer.
8. The wound dressing of claim 1 , wherein the moisture-vapor transmitting adhesive layer is a substantially continuous layer of pressure-sensitive polyurethane adhesive coated on the backing sheet.
9. The wound dressing of claim 1 , wherein the backing sheet comprises substantially closed-cell polyurethane foam.
10. The wound dressing of claim 1 , wherein the backing sheet is larger than the active layer and extends beyond one or more edges of the active layer to form a marginal region.
11. The wound dressing of claim 1 , which is sterile and packaged in a microorganism-impermeable container.
12. The wound dressing of claim 1 , wherein the stabilized ascorbate comprises ascorbate-2-triphosphate.
13. The wound dressing of claim 3 , wherein the active layer comprises from about 1 wt. % to about 10 wt. % of N-acetyl cysteine or salts thereof, and from about 1 wt. % to about 10 wt. % of the stabilized ascorbate.