Nicotine Formulations and Methods of Making the Same
A dry powder nicotine formulation suitable for inhalation is described. The formulation includes nicotine particles, wherein the nicotine particles are substantially in the range of about 1-10 micron in size, preferably 2-5 micron in size. The formulation may also include a cough suppressant component having particles in the 5-100 micron size range. The formulation may also include a cough suppressant component having particles in the 10-200 micron size range. The formulation may also include a flavor component having particles in the 10-1000 micron size range.
1 . A dry powder nicotine formulation suitable for inhalation comprising nicotine particles, wherein the nicotine particles are substantially between about 1-10 micron in size.
2 . The formulation of claim 1 , wherein the nicotine particles are substantially between about 2-5 micron in size.
3 . The formulation of claim 1 , wherein less than about 10% of the nicotine particles are less than about 1 micron in size.
4 . The formulation of claim 3 , wherein less than about 10% of the nicotine particles are less than about 2 micron in size.
5 . The formulation of claim 1 , wherein at least about 90% of the nicotine particles are less than about 10 micron in size.
6 . The formulation of claim 5 , wherein at least about 90% of the nicotine particles are less than about 5 micron in size.
7 . The formulation of claim 1 , wherein less than about 10% of the nicotine particles are less than about 1 micron in size and wherein at least about 90% of the nicotine particles are less than about 10 micron in size.
8 . The formulation of claim 2 , wherein less than about 10% of the nicotine particles are less than about 2 micron in size and wherein at least about 90% of the nicotine particles are less than about 5 micron in size.
9 . A dry powder nicotine formulation suitable for inhalation comprising:
a nicotine based component having particles substantially between about 1-10 micron in size; and
a cough suppressant component having particles substantially between about 5-10 micron in size.
10 . The formulation of claim 9 , wherein the cough suppressant component comprises menthol.
11 . The formulation of claim 10 , wherein the nicotine based component particles are substantially between about 2-5 micron in size and the cough suppressant component particles are substantially between about 5-8 micron in size.
12 . The formulation of claim 9 , further comprising a cough suppressant component having particles substantially between about 10-200 micron in size.
13 . The formulation of claim 12 , wherein the cough suppressant component having particles substantially between about 10-200 micron in size comprises menthol.
14 . The formulation of claim 9 , further comprising a flavor component having particles substantially between about 10-1000 micron in size.
15 . The formulation of claim 14 , wherein the flavor component comprises menthol.
16 . A method of producing a dry powder nicotine formulation suitable for inhalation, comprising the steps of:
preparing a flowable mixture comprising nicotine and a sugar in a liquid carrier; and
spray drying the flowable mixture to produce dry powder particles comprising nicotine and sugar, wherein the dry powder particles are substantially in the range of about 1-10 micron in size.
17 . The method of claim 16 , wherein the sugar is lactose.
18 . The method of claim 17 , wherein the lactose is non-spheronized.
19 . The method of claim 16 , wherein the liquid carrier is water.
20 . The method of claim 16 , wherein the liquid carrier comprises water and alcohol.
21 . A method of producing a dry powder nicotine formulation suitable for inhalation, comprising the steps of:
preparing a mixture comprising nicotine particles and carrier particles; and
milling the mixture to produce a dry powder nicotine formulation having particles substantially in the range of about 1-10 micron in size.
22 . The method of claim 21 , wherein the nicotine particles comprise nicotine tartrate.
23 . The method of claim 21 , wherein the carrier particles comprise lactose.
24 . The method of claim 21 , wherein the dry powder nicotine formulation is about 1.5 to 7% nicotine.
25 . The method of claim 21 , further comprising adding additional carrier particles after milling.
26 . The method of claim 21 , further comprising adding a cough suppressant component having a particle size range between 5-10 micron after milling.
27 . The method of claim 21 , further comprising adding a cough suppressant component having a particle size range between 5-200 micron after milling.
28 . The method of claim 21 , further comprising adding a flavor component having a particle size range between 10-1000 micron after milling.