Chewing gum compositions comprising cannabinoids
The present invention relates to a chewing gum composition comprising 0.01 to 15% by weight a cannabinoid or a derivative thereof, based on the total weight of the chewing gum composition, and to chewing gums and blistering packages comprising said chewing gums.
1. A chewing gum composition comprising, based on the total weight of the composition:
(a) 0.01 to 1% by weight of one or more cannabinoids, provided within internal voids of a solid cellulose carrier;
(b) 25 to 85% by weight of a gum base comprising at least one buffering agent;
(c) 10 to 35% by weight of at least one sweetening agent;
(d) 1 to 10% by weight of at least one flavouring agent; and
wherein 30% by weight of the cannabinoid is released within 5 minutes after ingestion, based on the total weight content of the cannabinoid in the chewing gum composition, and wherein the release starts within 3 minutes after ingestion.
2. The chewing gum composition according to claim 1 , wherein the cannabinoids comprise tetrahydrocannabinol (THC).
3. The chewing gum composition according to claim 1 , wherein the buffering agent is selected from the group consisting of acetates, glycinates, phosphates, carbonates, glycerophosphates, citrates, borates, and mixtures thereof.
4. The chewing gum composition according to claim 1 , wherein the sweetening agent is selected from the group consisting of xylitol, sorbitol, isomalt, aspartame, sucralose, acesulfame potassium, and saccharin.
5. The chewing gum composition according to claim 1 , wherein the flavouring agent is selected from the group consisting of menthol flavor, eucalyptus , mint flavor and/or L-menthol.
6. The chewing gum composition according to claim 1 , wherein the chewing gum composition comprises an antioxidant.
7. The chewing gum composition according to claim 1 , wherein the chewing gum composition comprises a pharmaceutically acceptable excipient selected from the group consisting of fillers, disintegrants, binders, lubricants, and antioxidants.
8. The chewing gum composition according to claim 1 , wherein the chewing gum composition is non-disintegrating.
9. The chewing gum composition according to claim 1 , wherein the chewing gum comprises natural cannabinoid obtained from cannabis.
10. The chewing gum composition according to claim 1 , wherein the sweetening agent is a sugar alcohol.
11. The chewing gum composition according to claim 1 , wherein the sweetening agent is selected from the group consisting of xylitol, sorbitol and/or isomalt.
12. A blister package comprising a chewing gum composition according to claim 1 .
13. A method for treating or alleviating pain a mammal in need thereof, comprising administering to said mammal a chewing gum composition according to claim 1 .
14. The method according to claim 13 , wherein the pain results from oral and cranio-maxillofacial surgery and/or disorders.
15. The method according to claim 13 , wherein the pain is chronic.
16. The chewing gum composition according to claim 1 , wherein the cannabinoids comprise THC and cannabidiol (CBD).