Topical compositions for pain relief, manufacture and use
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
1. A composition comprising:
i) 0.2-20% by weight of capsaicinoid,
ii) 0.1-0.5% by weight of hyaluronic acid, wherein said hyaluronic acid is a mixture of both low molecular weight hyaluronic acid and high molecular weight hyaluronic acid,
iii) 0.5-15% by weight nonionic surfactant,
wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
2. A composition comprising:
i) 2-20% by weight of capsaicinoid,
ii) 0.2-0.5% by weight of hyaluronic acid, and
iii) 2-15% by weight nonionic surfactant,
wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
3. A composition comprising:
i) 0.20-20% by weight of a capsaicinoid,
ii) 0.1-0.5% by weight hyaluronic acid,
iii) 2-15% by weight PS 80 or polyoxy 40 hydrogenated castor oil, and
iv) 1-40% by weight penetration enhancer,
wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
4. A composition comprising:
i) 0.20-20% by weight of a capsaicinoid,
ii) 0.1-1.5% by weight hyaluronic acid,
iii) 2-15% by weight PS 80 or polyoxy 40 hydrogenated castor oil, and
iv) 1-40% by weight of one or more penetration enhancers selected from the group consisting of DGME and propylene glycol,
wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
5. A composition as in claim 1 , wherein said capsaicinoid is capsaicin.
6. A composition as in claim 2 , wherein said capsaicinoid is capsaicin.
7. A composition as in claim 3 , wherein said capsaicinoid is capsaicin.
8. A composition as in claim 4 , wherein said capsaicinoid is capsaicin.
9. A composition as in claim 1 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
10. A composition as in claim 2 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
11. A composition as in claim 3 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
12. A composition as in claim 4 , wherein said capsaicinoid is trans-capsaicin or nonivamide.
13. A composition as in claim 2 , wherein said hyaluronic acid is a mixture of both low molecular weight hyaluronic acid and high molecular weight hyaluronic acid.
14. A composition as in claim 3 , wherein said hyaluronic acid is a mixture of both low molecular weight hyaluronic acid and high molecular weight hyaluronic acid.
15. A composition as in claim 4 , wherein said hyaluronic acid is a mixture of both low molecular weight hyaluronic acid and high molecular weight hyaluronic acid.
16. A composition as in claim 1 , wherein said nonionic surfactant is PS 80.
17. A composition as in claim 2 , wherein said nonionic surfactant is PS 80.
18. A composition as in claim 3 , wherein the composition comprises 2-15% by weight PS 80.
19. A composition as in claim 4 , wherein the composition comprises 2-15% by weight PS 80.
20. A composition as in claim 1 , wherein said nonionic surfactant is polyoxy 40 hydrogenated castor oil.
21. A composition as in claim 2 , wherein said nonionic surfactant is polyoxy 40 hydrogenated castor oil.
22. A composition as in claim 3 , wherein the composition comprises 2-15% by weight polyoxy 40 hydrogenated castor oil.
23. A composition as in claim 4 , wherein the composition comprises 2-15% by weight polyoxy 40 hydrogenated castor oil.
24. A composition as in claim 1 further comprising a penetration enhancer.
25. A composition as in claim 2 further comprising a penetration enhancer.
26. A composition as in claim 24 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
27. A composition as in claim 25 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
28. A composition as in claim 3 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
29. A composition as in claim 4 , wherein said penetration enhancer is selected from the group consisting of DGME or propylene glycol.
30. A composition as in claim 1 further comprising an alcohol.
31. A composition as in claim 2 further comprising an alcohol.
32. A composition as in claim 3 further comprising an alcohol.
33. A composition as in claim 4 further comprising an alcohol.
34. A composition as in claim 30 , wherein said alcohol is ethanol.
35. A composition as in claim 31 , wherein said alcohol is ethanol.
36. A composition as in claim 32 , wherein said alcohol is ethanol.
37. A composition as in claim 33 , wherein said alcohol is ethanol.
38. A composition as in claim 1 further comprising an analgesic or anesthetic agent.
39. A composition as in claim 2 further comprising an analgesic or anesthetic agent.
40. A composition as in claim 3 further comprising an analgesic or anesthetic agent.
41. A composition as in claim 4 further comprising an analgesic or anesthetic agent.
42. A composition as in claim 38 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
43. A composition as in claim 39 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
44. A composition as in claim 40 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
45. A composition as in claim 41 , wherein said analgesic agent or anesthetic agent is selected from the group consisting of methyl salicylate, camphor, menthol, icilin, eucalyptol and phenol.
46. A composition as in claim 1 further comprising an anti-inflammatory agent.
47. A composition as in claim 2 further comprising an anti-inflammatory agent.
48. A composition as in claim 3 further comprising an anti-inflammatory agent.
49. A composition as in claim 4 further comprising an anti-inflammatory agent.
50. A composition as in claim 46 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
51. A composition as in claim 47 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
52. A composition as in claim 48 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
53. A composition as in claim 49 , wherein said anti-inflammatory agent is selected from the group consisting of a flavonoid, a steroid, and an NSAID.
54. A composition as in claim 1 , wherein the composition is a liquid solution.
55. A composition as in claim 2 , wherein the composition is a liquid solution.
56. A composition as in claim 3 , wherein the composition is a liquid solution.
57. A composition as in claim 4 , wherein the composition is a liquid solution.
58. A composition as in claim 1 further comprising phenol.
59. A composition as in claim 2 further comprising phenol.
60. A composition as in claim 3 further comprising phenol.
61. A composition as in claim 4 further comprising phenol.
62. A kit comprising:
i) a composition as in claim 1 , and
ii) a non occlusive applicator device.
63. A kit comprising:
i) a composition as in claim 2 , and
ii) a non occlusive applicator device.
64. A kit comprising:
i) a composition as in claim 3 , and
ii) a non occlusive applicator device.
65. A kit comprising:
i) a composition as in claim 4 , and
ii) a non occlusive applicator device.
66. A kit as in claim 62 further comprising a cleaning solution for removal of residual capsaicinoid.
67. A kit as in claim 63 further comprising a cleaning solution for removal of residual capsaicinoid.
68. A kit as in claim 64 further comprising a cleaning solution for removal of residual capsaicinoid.
69. A kit as in claim 65 further comprising a cleaning solution for removal of residual capsaicinoid.