Anti-cMet/anti-EGFR/anti-HER3 multispecific antibodies and use thereof
An anti-EGFR/anti-HER3 antibody or antigen binding fragment thereof, and a method of preventing and/or treating a cancer using the same.
1. An anti-c-Met/anti-EGFR/anti-HER3 multispecific antibody comprising a complete form of an anti-c-Met antibody and an anti-EGFR/anti-HER3 bispecific scFv conjugated to the C-terminus of the anti-c-Met antibody, wherein
the anti-c-Met antibody comprises a heavy chain comprising the 18 th to 460 th positions of SEQ ID NO: 66, and a light chain comprising the 21 st to 240 th positions of SEQ ID NO: 68;
and the anti-EGFR/anti-HER3 bispecific scFv comprises SEQ ID NO: 119.
2. A method of treating a cancer comprising administering the anti-c-Met/anti-EGFR/anti-HER3 multispecific antibody of claim 1 to a subject in need of cancer treatment.
3. A pharmaceutical composition comprising the anti-c-Met/anti-EGFR/anti-HER3 multispecific antibody of claim 1 and a pharmaceutically acceptable carrier.
4. A method of preparing the anti-c-Met/anti-EGFR/anti-HER3 multispecific antibody of claim 1 , the method comprising expressing a nucleic acid encoding the anti-c-Met/anti-EGFR/anti-HER3 multispecific antibody of claim 1 in an isolated host cell.