IP Library › Granted Patent US 9,540,368
Granted Patent B2
US 9,540,368 · App. 14/693,424 · Granted Jan 10, 2017

1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins

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Quick Facts
Patent No.
US 9,540,368
App. No.
14/693,424
Granted
Jan 10, 2017
Kind
B2
Abstract

The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

Claims (4)

1. A compound which is 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one,-or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.

3. A compound which is 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one.

4. A pharmaceutical composition comprising the compound of claim 3 and at least one pharmaceutically acceptable carrier.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 10, 2021
From: INCYTE CORPORATION
To: INCYTE CORPORATION; INCYTE HOLDINGS CORPORATION
Reel/Frame 058815/0857 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNOR NAME PREVIOUSLY RECORDED AT REEL: 035776 FRAME: 0071. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Aug 3, 2016
From: COMBS, ANDREW P.; MADUSKUIE, THOMAS P.; FALAHATPISHEH, NIKOO
To: INCYTE CORPORATION
Reel/Frame 039559/0312 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2015
From: COMBS, ANDREW P.; MADUSKUIE, THOMAS P., JR; FALAHAPTISHEH, NIKOO
To: INCYTE CORPORATION
Reel/Frame 035776/0071 →