Resorbable oxidized cellulose embolization solution
A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10 % by weight to 20 % by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.
1. A method for forming an embolism within a blood vessel comprising:
introducing an oxidized cellulose embolization solution including an oxidized cellulose into a lumen of a blood vessel to form an embolism within the lumen, wherein the oxidized cellulose is present in an amount from about 1% by weight to 20% by weight of the oxidized cellulose embolization solution.
2. The method according to claim 1 , further comprising guiding an implantation device comprising the oxidized cellulose embolization solution through the lumen.
3. The method according to claim 2 , wherein guiding the implantation device comprises imaging the blood vessel.
4. The method according to claim 1 , wherein the oxidized cellulose embolization solution includes a solvent selected from the group consisting of N-methyl-2-pyrrolidinone, dimethyl sulfoxide, and combinations thereof.
5. The method according to claim 1 , wherein the oxidized cellulose embolization solution includes at least one of a bioactive agent, a visualization agent, a radioactive material, a hemostatic agent, or a radio-protective agent.
6. The method according to claim 1 , further comprising:
adjusting recanalization time of the embolism.
7. The method according to claim 6 , wherein adjustment of the recanalization time includes adjusting a degradation rate of the oxidized cellulose.
8. The method according to claim 7 , wherein adjustment of the degradation rate of the oxidized cellulose includes adjusting at least one of degree of oxidation or molecular weight distribution of the oxidized cellulose.
9. A method for treating a tumor comprising:
identifying at least one arterial blood vessel supplying blood to a tumor;
selecting at least one of degree of oxidation or molecular weight distribution of an oxidized cellulose of an oxidized cellulose embolization solution, the oxidized cellulose present in an amount from about 10% by weight to about 20% by weight of the oxidized cellulose embolization solution;
guiding an implantation device including the oxidized cellulose embolization solution through a lumen of the at least one arterial blood vessel; and
introducing the oxidized cellulose embolization solution into the lumen through the implantation device to form an embolism within the lumen and impede supply of blood to the tumor, wherein recanalization time of the embolism is based on the selection of at least one of the degree of oxidation or the molecular weight distribution of the oxidized cellulose.
10. The method according to claim 9 , wherein guiding the implantation device comprises imaging the at least one arterial blood vessel.
11. The method according to claim 9 , wherein the oxidized cellulose embolization solution includes a solvent selected from the group consisting of N-methyl-2-pyrrolidinone, dimethyl sulfoxide, and combinations thereof.
12. The method according to claim 9 , wherein the oxidized cellulose embolization solution includes at least one of a bioactive agent, a visualization agent, a radioactive material, a hemostatic agent, or a radio-protective agent.
13. The method according to claim 9 , further comprising adjusting a degradation rate of the oxidized cellulose to adjust the recanalization time of the embolism.
14. A method for forming an embolism within a blood vessel comprising:
selecting at least one of degree of oxidation or molecular weight distribution of oxidized cellulose of an oxidized cellulose embolization solution, the oxidized cellulose present in an amount from about 10% by weight to about 20% by weight of the oxidized cellulose embolization solution; and
introducing the oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen, wherein recanalization time of the embolism is adjusted by the adjustment of at least one of the degree of oxidation or the molecular weight distribution of the oxidized cellulose.
15. The method according to claim 14 , further comprising guiding an implantation device comprising the oxidized cellulose embolization solution through the lumen.
16. The method according to claim 15 , wherein guiding the implantation device comprises imaging the blood vessel.
17. The method according to claim 14 , wherein the oxidized cellulose embolization solution includes a solvent selected from the group consisting of N-methyl-2-pyrrolidinone, dimethyl sulfoxide, and combinations thereof.
18. The method according to claim 14 , wherein the oxidized cellulose embolization solution includes at least one of a bioactive agent, a visualization agent, a radioactive material, a hemostatic agent, or a radio-protective agent.
19. The method according to claim 14 , further comprising adjusting a degradation rate of the oxidized cellulose to adjust the recanalization time of the embolism.