Adenovirus vectors
View Patent ↗An adenoviral vector comprising a promoter further comprising a fragment of the 5′ untranslated region of the CMV IE1 gene including intron A and a nucleic acid sequence encoding a pathogen or tumor antigen for use as a medicament.
1. An adenoviral vector comprising a promoter and a nucleic acid sequence encoding an antigen from a pathogen or a tumour antigen under the control of said promoter, wherein said promoter consists of SEQ ID NO: 7, and wherein said antigen is not a murine malaria parasite antigen.
2. The adenoviral vector according to claim 1 , wherein the adenoviral vector is a simian adenoviral vector.
3. The adenoviral vector according to claim 1 , wherein the adenoviral vector is AdC6 (C6), AdC7 (C7), or AdC9 (C9) vector.
4. An immunogenic composition comprising the adenoviral vector of claim 1 admixed with one or more pharmaceutically acceptable vehicles, carriers, diluents, or adjuvants.
5. A product, combination or kit comprising;
a) a priming composition comprising the adenoviral vector according to claim 1 ; and
b) a boosting composition comprising a recombinant pox virus vector, said pox virus vector further comprising at least one nucleic acid sequence encoding a pathogen or tumour antigen which is the same as the antigen of the priming composition.
6. The product, the combination or the kit according to claim 5 , wherein the promoter excludes Exon B of the CMV IE1 gene.
7. A composition comprising the immunogenic composition according to claim 4 and a CpG adjuvant.