Osteoinductive bone graft substitute
View Patent ↗An osteoinductive bone graft substitute including an osteoinductive calcium phosphate component retained within a collagen scaffold, wherein the collagen scaffold is formulated to maintain the osteoinductivity of the calcium phosphate component while also exhibiting the following characteristics (1) ability to absorb bone marrow and/or other physiologic liquids, (2) compression resistance; (3) moldability; (4) retaining the calcium phosphate component during and after manipulation of the collagen scaffold and (5) fibrous collagen matrix that retains but does not occlude the osteoinductive calcium phosphate component.
1. A method of making an osteoinductive bone graft substitute, comprising:
mixing a first soluble collagen solution having a first concentration with osteoinductive calcium phosphate granules to create a slurry;
blending the slurry with a second soluble collagen solution having a second concentration which is greater than the first concentration to create a mixture having a final collagen concentration of 65 mg/g;
pouring the mixture into a mold; and
lyophilizing the mixture.
2. The method of making an osteoinductive bone graft of claim 1 , wherein the first collagen solution has a concentration of 12.5 mg/g.
3. The method of making an osteoinductive bone graft of claim 1 , wherein the second collagen solution has a concentration of 100 mg/g.
4. The method of making an osteoinductive bone graft of claim 1 , wherein the osteoinductive calcium phosphate comprises greater than 90% β-TCP and less than 10% hydroxyapatite.
5. The method of making an osteoinductive bone graft of claim 1 , wherein the osteoinductive calcium phosphate comprises 100% β-TCP.