Process for preparing 3-methylsulfonylpropionitrile
The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 2θ, and wherein the most intense peak is the peak at 13.9±0.1 degrees 2θ.
1. A method for preparing 3-methylsulfonylpropionitrile, comprising:
(a) reacting 3-bromopropionitrile and sodium methylsulfinate in a solvent for a sufficient time to form 3-methylsulfonylpropionitrile and a byproduct sodium bromide, and
(b) removing the byproduct.
2. The method according to claim 1 , further comprising a step (c) after step (b):
(c) purifying 3-methylsulfonylpropionitrile.
3. The method according to claim 1 , wherein the step (a) comprises:
(i) reacting 3-bromopropionitrile and sodium methylsulfinate at ≧40° C. for at least 8 hours,
(ii) cooling the reaction mixture to ≦15° C., and
(iii) isolating 3-methylthiopropionitrile in a solid form from the cooled reaction mixture.
4. The method according to claim 1 , wherein 3-bromopropionitrile and sodium methylsulfinate are reacted at 75-83° C.
5. The method according to claim 1 , wherein the byproduct is removed by:
(i) adding acetone to 3-methylsulfonylpropionitrile and the byproduct of step (a) to form a solution,
(ii) filtering the solution of (i) to remove the insoluble byproduct, and
(iii) collecting the filtrate.
6. The method according to claim 5 , further comprising purifying 3-methylsulfonylpropionitrile by drying the filtrate of (iii), dissolving the dried material in an organic solvent, and crystallizing 3-methylsulfonylpropionitrile.