Method for treating cerebral amyloid angiopathy using pharmacological chaperones to increase the activity of gangliosidases
View Patent ↗The present invention relates to a method for treating an individual having Cerebral Amyloid Angiopathy by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.
1. A method for the treatment of Cerebral Amyloid Angiopathy in an individual, comprising administering to the individual an effective amount of a pharmacological chaperone, wherein the pharmacological chaperone is selected from 2-acetamido-1,2-dideoxynojirimycin and N-acetyl-glucosamine-thiazoline.
2. The method of claim 1 , wherein the pharmacological chaperone increases production of sAPPα.
3. The method of claim 1 , wherein the pharmacological chaperone is 2-acetamido-1,2-dideoxynojirimycin.
4. The method of claim 1 , wherein the pharmacological chaperone is N-acetylglucosamine-thiazoline.
5. The method of claim 1 , wherein the Cerebral Amyloid Angiopathy is Familial Cerebral Amyloid Angiopathy.
6. The method of claim 5 , wherein the Familial Cerebral Amyloid Angiopathy is caused by a mutation in amyloid precursor protein (APP).