Ultra low density pulmonary powders
View Patent ↗The invention provides pharmaceutical compositions for pulmonary delivery comprising particles containing a pharmaceutical agent and having a geometric size of greater than about 5 μm and a tap density of less than about 0.075 g/cm 3 . The invention also provides methods for delivering the pharmaceutical compositions of the invention to the respiratory tract of a patient.
1. A pharmaceutical composition for pulmonary delivery comprising particles of levodopa having:
a geometric size of about 8 μm to about 12 μm;
a tap density of about 0.025 g/cm 3 to about 0.050 g/cm 3 ;
a water content between 1.90 and 2.90 weight percent.
2. The pharmaceutical composition of claim 1 , wherein said particles comprise a phospholipid.
3. The pharmaceutical composition of claim 1 , wherein said particles comprise a salt.
4. The pharmaceutical composition of claim 1 , wherein said particles comprise a surfactant.
5. The pharmaceutical composition of claim 1 , wherein said particles comprise a polymer.
6. The pharmaceutical composition of claim 1 , wherein said particles comprise a sugar.
7. The pharmaceutical composition of claim 1 , wherein said particles have an aerodynamic diameter of between about 2.5 μm and 5 μm.
8. The pharmaceutical composition of claim 1 , wherein said particles have an external surface area of about 10 m 2 /g to about 50 m 2 /g.
9. The pharmaceutical composition of claim 1 , wherein said particles further comprise a salt and a phospholipid.