IP Library Granted Patent US 9,539,249
Granted Patent B2
US 9,539,249 · App. 14/707,122 · Granted Jan 10, 2017

PPAR gamma agonists for treatment of multiple sclerosis

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Quick Facts
Patent No.
US 9,539,249
App. No.
14/707,122
Granted
Jan 10, 2017
Kind
B2
Abstract

Methods of treatment of multiple sclerosis (MS) with PPARγ agonists, and in particular with the compound of formula (I) known as INT131:

Claims (8)

1. A method of treating relapsing and remitting multiple sclerosis (RRMS) in a patient in need thereof at a regular dosing interval comprising administering to said patient a pharmaceutical composition comprising from about 1 to about 3 milligrams of a compound of formula (I),

or a pharmaceutically acceptable salt, prodrug, or isomer thereof.

2. The method of claim 1 wherein said administering the compound of formula (I) is about 3 milligrams per day.

3. The method of claim 1 , wherein said regular dosing interval is once per day.

4. A method of treating the symptoms of relapsing and remitting multiple sclerosis (RRMS) comprising administering to a patient in need thereof at a regular dosing interval from about 1 to about 3 milligrams of a compound of formula (I),

or a pharmaceutically acceptable salt, prodrug or isomer thereof.

5. The method of claim 4 wherein said administering the compound of formula (I) is about 3 milligrams per day.

6. The method of claim 4 , wherein said regular dosing interval is once per day.

Assignments (6)
TERMINATION AND RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY AT REEL/FRAME NO. 59436/0055 Recorded May 9, 2024
From: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
To: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
Reel/Frame 067378/0256 →
SECURITY INTEREST Recorded May 8, 2024
From: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.; SURFACE ONCOLOGY, LLC; COHERUS ONCOLOGY SUPPORTIVE CARE LLC
To: ANKURA TRUST COMPANY, LLC
Reel/Frame 067348/0160 →
SECURITY INTEREST Recorded Mar 18, 2022
From: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 059436/0055 →
RELEASE OF NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS AT REEL/FRAME NO. 048021/0975 Recorded Jan 11, 2022
From: HCR COLLATERAL MANAGEMENT, LLC
To: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
Reel/Frame 058692/0665 →
SECURITY INTEREST Recorded Jan 7, 2019
From: COHERUS BIOSCIENCES, INC.; COHERUS INTERMEDIATE CORP.; INTEKRIN THERAPEUTICS INC.
To: HCR COLLATERAL MANAGEMENT, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 048021/0975 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 8, 2015
From: WEINSTEIN, DAVID
To: INTEKRIN THERAPEUTICS, INC.
Reel/Frame 035626/0182 →