IP Library Granted Patent US 10,849,687
Granted Patent B2
US 10,849,687 · App. 14/708,828 · Granted Dec 1, 2020

Picosecond laser apparatus and methods for its operation and use

Inventors: Rafael Armando Sierra (Palmer, MA); Mirko Mirkov (Chelmsford, MA); Richard Shaun Welches (Manchester, NH)
Assignee: Cynosure, LLC
A61B18/203A61N5/0616H01S3/00A61B2017/00769A61B2018/0047A61B2018/00452A61N2005/067G02F1/0327H01S3/107H01S3/1103H01S3/115H01S3/1109
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Quick Facts
Patent No.
US 10,849,687
App. No.
14/708,828
Granted
Dec 1, 2020
Kind
B2
Abstract

Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with the capability of switching between a modelocked pulse operating mode and an amplification operating mode. The operating modes are carried out through the application of a time-dependent bias voltage, having waveforms as described herein, to an electro-optical device (e.g., a Pockels cell) positioned along the optical axis of the resonator.

Claims (24)

1. A method for treating a skin pigmentation comprising pigment particles using a photomechanical process, the method comprising exposing at least one pigment particle to pulsed laser energy having a wavelength between 660 nm and 1090 nm and with pulses having a duration that is a multiple of the acoustic transit time across said pigment particle to photomechanically disrupt the pigment particle.

2. The method of claim 1 wherein said pulses have an energy of at least 100 mj.

3. The method of claim 1 wherein said duration is less than 1 nanosecond.

4. The method of claim 1 wherein said duration is at most 500 ps.

5. The method of claim 1 wherein said pulses have a duration of between 100 ps and 300 ps.

6. The method of claim 1 wherein said pulses have a duration of between 100 ps and 500 ps.

7. The method of claim 1 comprising exposing said at least one pigment particle to pulsed laser energy with pulses having a duration below twice the acoustic transit time across said pigment particle.

8. The method of claim 7 wherein said duration is less than 1 nanosecond.

9. The method of claim 7 wherein said pulses have an energy of at least 100 mj.

10. The method of claim 1 comprising exposing said at least one pigment particle to pulsed laser energy with pulses having a duration below five times the acoustic transit time across said pigment particle.

11. The method of claim 10 wherein said duration is less than 1 nanosecond.

12. The method of claim 10 wherein said pulses have an energy of at least 100 mj.

13. The method of claim 1 wherein said pigment particle is in a tattoo.

14. The method of claim 1 wherein said pigment particle is in a birthmark.

15. The method of claim 1 wherein said pigment particle is in a pigmented lesion.

16. The method of claim 1 wherein said pigment particle is in a skin pigmentation.

17. The method of claim 1 wherein the duration is from two times to five times the acoustic transit time across the pigment particle.

18. The method of claim 1 wherein the at least one pigment particle has a diameter of from 1 micron to 10 microns.

19. The method of claim 1 wherein the pigment particle has a diameter from 1 micron to 10 microns.

20. The method of claim 1 wherein the wavelength is between 660 nm and 1060 nm.

21. The method of claim 1 wherein the wavelength is between 980 nm and 1090 nm.

22. The method of claim 1 wherein the wavelength is between 700 nm and 950 nm.

23. The method of claim 1 wherein the wavelength is 694 nm.

24. The method of claim 1 wherein the wavelength is 1064 nm.

Assignments (10)
PARTIAL RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 042261/0911 Recorded Apr 24, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: CYNOSURE, LLC, AS SUCCESSOR-BY-CONVERSION TO CYNOSURE, INC.
Reel/Frame 075456/0791 →
RELEASE OF SECURITY INTEREST Recorded Mar 1, 2024
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION
To: CYNOSURE, LLC; PALOMAR MEDICAL TECHNOLOGIES, LLC
Reel/Frame 066723/0227 →
TERMINATION AND RELEASE OF PATENTS Recorded Feb 29, 2024
From: UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT
To: CYNOSURE, LLC; PALOMAR MEDICAL TECHNOLOGIES, LLC
Reel/Frame 066707/0957 →
ABL NOTICE AND CONFIRMATION OF GRANT OFSECURITY INTEREST IN PATENTS Recorded Jan 12, 2024
From: CYNOSURE, LLC; PALOMAR MEDICAL TECHNOLOGIES, LLC
To: UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT
Reel/Frame 066222/0937 →
NOTICE AND CONFIRMATION OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Jan 7, 2020
From: CYNOSURE, LLC; PALOMAR MEDICAL TECHNOLOGIES, LLC
To: U.S. BANK NATIONAL ASSOCIATION
Reel/Frame 051496/0579 →
RELEASE OF SECURITY INTEREST IN PATENT RIGHTS Recorded Dec 30, 2019
From: BANK OF AMERICA, N.A.
To: CYNOSURE, LLC
Reel/Frame 051447/0536 →
SECURITY INTEREST Recorded Oct 14, 2019
From: HOLOGIC, INC.; CYNOSURE, LLC; CYTYC CORPORATION; FAXITRON BIOPTICS, LLC; FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 050719/0701 →
CHANGE OF NAME Recorded Mar 26, 2019
From: CYNOSURE, INC.
To: CYNOSURE, LLC
Reel/Frame 048696/0811 →
SECURITY INTEREST Recorded May 3, 2017
From: CYNOSURE, INC.; PALOMAR MEDICAL TECHNOLOGIES, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 042261/0911 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 11, 2017
From: SIERRA, RAFAEL ARMANDO; MIRKOV, MIRKO; WELCHES, RICHARD SHAUN
To: CYNOSURE, INC.
Reel/Frame 041960/0116 →