Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient
View Patent ↗The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO 2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a break-through of NO 2 , and providing an indication of the remaining useful life and/or break-through.
1. A system for safely delivering a supply of nitric oxide (NO) to a recipient, comprising:
a gas source that supplies a gas, wherein the gas supplied by the gas source is nitrogen dioxide (NO 2 );
a gas conduit connected to and in fluid communication with the gas source;
a NO 2 -to-NO reactor cartridge connected to and in fluid communication with the gas conduit, so as to allow gas to flow from the gas source to an inlet end of the NO 2 -to-NO reactor cartridge, wherein the NO 2 -to-NO reactor cartridge comprises a consumable conversion media;
one or more sensor probe(s) configured to monitor functioning of the NO 2 -to-NO reactor cartridge operatively associated with the NO 2 -to-NO reactor cartridge, wherein the one or more sensor probe(s) are embedded into the consumable conversion media and the one or more sensor probe(s) is a moisture sensor configured to determine an amount of moisture present in the consumable conversion media;
a delivery conduit connected to and in fluid communication with an outlet end of the NO 2 -to-NO reactor cartridge, wherein the delivery conduit is operable to allow NO gas from the NO 2 -to-NO reactor cartridge to flow to the recipient;
a computer in electronic communication with the one or more sensor probe(s) over a communication path, wherein the computer is configured to receive electronic signals from the one or more sensor probe(s) and calculate a performance value; and
a regulating means in electronic communication with the computer over a communication path, wherein the regulating means is controlled based on the performance value.
2. The system of claim 1 , further comprises a flow meter for measuring an amount of gas entering the NO 2 -to-NO reactor cartridge.
3. The system of claim 1 , further comprises a flow meter for measuring an amount of gas being delivered to the recipient.
4. The system of claim 1 , further comprises an NO 2 sensor operationally associated with the delivery conduit configured to a presence of an unacceptable level of NO 2 in the gas being directed to the recipient.
5. The system of claim 1 , wherein the performance value is calculated and utilized for comparison with a predetermined threshold value, the computer is configured to generate an actuating signal when the performance value falls below the threshold value, and the regulating means is configured to receive the actuating signal from the computer, wherein the regulating means is configured to halt the delivery of the gas to a recipient when the actuating signal is received from the computer.
6. The system of claim 5 , wherein the threshold value indicates that a predetermined amount of the consumable conversion media has been reached, and wherein the computer is configured to alert a user through a display, an audible alarm, or both that the NO 2 -to-NO reactor cartridge is exhausted or compromised.
7. The system of claim 1 , wherein the one or more sensor probe(s) is configured to further detect or measure the concentration of ascorbic acid, the concentration of dehydroascorbic acid, the concentration of water (H 2 O), the concentration of NO 2 , the concentration of NO, the concentration of O 2 , the concentration of HNO 3 , the pH of at least a portion of the NO 2 -to-NO reactor cartridge, the redox potentials of chemical species in the NO 2 -to-NO reactor cartridge, the mass flow rate of gases, the conductance at the surface of the silica gel, or combinations thereof.
8. A method of monitoring the performance of a nitrogen dioxide (NO 2 )-to-nitric oxide (NO) reactor cartridge, the method comprising:
incorporating one or more sensor probe(s) into an NO 2 -to-NO reactor cartridge comprising a conversion media, wherein the one or more sensor probe(s) are operatively associated with the NO 2 -to-NO reactor cartridge and the one or more sensor probe(s) is a moisture sensor configured to determine the amount of moisture present in the conversion media; and
operatively associating at least one meter with the one or more sensor probe(s) and wherein the one or more sensor probe(s) are embedded into the conversion media; calculating a performance value based on electronic signals from the one or more sensor probe(s); and controlling a regulating means based on the performance value.
9. The method of claim 8 , which further comprises incorporating the NO 2 -to-NO reactor cartridge into an NO delivery system, wherein the NO 2 -to-NO reactor cartridge is connected to and in fluid communication with a gas source conduit that is configured to contain and direct a gas from a gas source to the NO 2 -to-NO reactor cartridge.
10. The method of claim 9 , which further comprises detecting physical and/or chemical characteristics of the conversion media with the one or more sensor probe(s);
measuring the detected physical and/or chemical characteristics with the operatively associated meter;
communicating the measured physical and/or chemical characteristics to a computer; and monitoring the communicated characteristics with the computer.
11. The method of claim 8 , wherein the conversion media comprises a packing material coated with ascorbic acid, alpha tocopherol, or gamma tocopherol, and a color agent.
12. A system for safely delivering a supply of nitric oxide (NO) to a recipient, comprising:
a gas source that supplies a gas, wherein the gas is nitrogen dioxide (NO 2 ) or NO;
a gas conduit connected to and in fluid communication with the gas source;
a NO 2 -to-NO reactor cartridge connected to and in fluid communication with the gas conduit, so as to allow gas to flow from the gas source to an inlet end of the NO 2 -to-NO reactor cartridge, wherein the NO 2 -to-NO reactor cartridge comprises a consumable conversion media;
one or more sensor probe(s) configured to monitor functioning of the NO 2 -to-NO reactor cartridge operatively associated with the NO 2 -to-NO reactor cartridge, wherein the one or more sensor probes are embedded into the consumable conversion media and the one or more sensor probe(s) is a moisture sensor configured to determine an amount of moisture present in the consumable conversion media;
a delivery conduit connected to and in fluid communication with an outlet end of the NO 2 -to-NO reactor cartridge, wherein the delivery conduit is operable to allow NO gas from the NO 2 -to-NO reactor cartridge to flow to the recipient;
a computer in electronic communication with the one or more sensor probe(s) over a communication path, wherein the computer is configured to receive electronic signals from the one or more sensor probe(s) and calculate a performance value for comparison with a predetermined threshold value, and configured to generate an actuating signal when the performance value falls below the threshold value; and
a regulating means in electronic communication with the computer over a communication path, wherein the regulating means is configured to receive the actuating signal from the computer, and wherein the regulating means halts the delivery of the gas to a recipient.
13. The system of claim 12 , wherein the NO 2 -to-NO reactor cartridge comprises an outer reactor shell, an inlet, an outlet, and the consumable conversion media including solid packing material coated with consumable reactant.
14. The system of claim 12 , wherein the gas source is encased within an outer housing.