Treatment for vitiligo
Compounds I and II, as well as prodrugs, hydrates, solvates, N-oxides, salts and pharmaceutical compositions containing them, are useful for treating vitiligo. In certain embodiments, the compounds are provided in topical compositions.
1. A method of treating vitiligo, comprising administering to a subject a topical formulation comprising from 0.1% to 10% (w/w) of a compound
or a hydrate, a solvate, an N-oxide, or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the subject is identified as having vitiligo.
3. The method of claim 1 , wherein the subject is identified as being at risk of developing vitiligo.
4. The method of claim 1 , wherein administering the topical formulation comprises administering a therapeutically effective amount of from about 0.0001 mg/kg/day to about 100 mg/kg/day.
5. The method of claim 1 , wherein the topical formulation comprises from 0.2% to 6% (w/w) of the compound.
6. The method of claim 1 , wherein the topical formulation comprises 3% (w/w) of the compound.
7. The method of claim 1 , wherein the topical formulation comprises 6% (w/w) of the compound.
8. The method of claim 5 , wherein the formulation comprises 30% to 40% (w/w) polyethylene glycol with an average molecular weight of from 4000 to 5000 Daltons.
9. The method of claim 1 , wherein the subject has one or more depigmented skin areas, and the method comprises administering the compound topically to at least one of the depigmented skin areas.
10. The method of claim 5 , further comprising administering the compound systemically to the subject.
11. The method of claim 1 , comprising administering the compound systemically to the subject.
12. The method of claim 1 , wherein the subject has vitiligo of the eye, and the compound ocularly to the patient.
13. The method of claim 1 , comprising administering the compound either in combination or adjunctively with a second therapeutic.
14. The method of claim 11 , wherein the second therapeutic is an anti-inflammatory, an antihistamine, an antibiotic, an antiviral medication, systemic phototherapy, psoralen photochemotherapy, excimer laser therapy, thyroid hormone replacement medication, or any combination thereof.