IP Library › Granted Patent US 9,595,100
Granted Patent B2
US 9,595,100 · App. 14/724,423 · Granted Mar 14, 2017

Method and system for processing an image of a biological specimen

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Quick Facts
Patent No.
US 9,595,100
App. No.
14/724,423
Granted
Mar 14, 2017
Kind
B2
Abstract

Components, e.g., background, cytoplasm, nucleus and nucleolus, of a biological specimen are identified using multi-wavelength analysis. Specimen components, such as nucleoli, are selected, and a determination is made whether cells having nucleoli are cancer cells or regular repair cells based on one or more physical characteristics of the identified component. The physical characteristics can be one or more of a shape, size, texture and gray value.

Claims (32)

1. A method of processing an image of a biological specimen using an image processor, the specimen image including a plurality of cells, the method comprising:

identifying a component of one of the cells in the image; and

evaluating a characteristic of the component in order to determine whether the respective cell having the component has a likelihood of being a cancerous cell or a repair cell,

wherein evaluating a characteristic of the component comprises:

comparing one or more characteristics of the component to one or more characteristics of a component of a cell known to be cancerous;

comparing one or more characteristics of the component to one or more characteristics of a component of a cell known to be a repair cell; and

determining, based on the respective comparisons, whether the respective cell having the component has a likelihood of being a cancerous cell or a repair cell.

2. The method of claim 1 , wherein the characteristic comprises a physical characteristic.

3. The method of claim 1 , wherein the characteristic comprises a statistical characteristic.

4. The method of claim 1 , wherein the identified component comprises a nucleoli.

5. The method of claim 1 , wherein identifying a component comprises using a multi-wavelength spectral analysis to identify the component.

6. The method of claim 1 , wherein evaluating a characteristic of the component further comprises using multi-wavelength spectral analysis to determine transmission characteristics of the component.

7. The method of claim 1 , further comprising:

determining that the cell having the component has a likelihood of being cancerous; and

presenting the cell to a reviewer for further review.

8. A method of processing an image of a biological specimen using an image processor, the specimen image including a plurality of cells, the method comprising:

identifying a component of one of the cells in the image; and

evaluating a characteristic of the component in order to determine whether the respective cell having the component has a likelihood of being a cancerous cell or a repair cell,

wherein the identified component comprises a nucleus, and wherein evaluating a characteristic of the component comprises evaluating transmission characteristics of the nucleus, and

wherein evaluating transmission characteristics of the nucleus comprises

comparing transmission characteristics of the nucleus to transmission characteristics of nuclei of cells known to be cancerous,

comparing transmission characteristics of the nucleus to transmission characteristics of nuclei of cells known to be repair cells, and

determining, based on the respective comparisons, whether the respective cell having the identified nucleus has a likelihood of being a cancerous cell or a repair cell.

9. A method of processing an image of a biological specimen using an image processor, the specimen image including a plurality of cells, the method comprising:

identifying a component of one of the cells in the image; and

evaluating a characteristic of the component in order to determine whether the respective cell having the component has a likelihood of being a cancerous cell or a repair cell,

wherein evaluating a characteristic of the component comprises:

determining a repair score for the component;

determining a cancer score for the component;

comparing the repair score to the cancer score; and

determining, based on the comparison, whether the respective cell having the component has a likelihood of being a cancerous cell or a repair cell.

10. The method of claim 9 , wherein the identified component comprises a nucleoli or nucleus.

Assignments (3)
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
SECURITY AGREEMENT Recorded Oct 14, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LLC; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036855/0468 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2015
From: WONG, KAM LIN; ZAHNISER, DAVID; MUI, KATHY; LINDER, JIM; SHEETS, ELLEN
To: CYTYC CORPORATION
Reel/Frame 035824/0789 →