Microfabricated nanopore device for sustained release of therapeutic agent
A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.
1. A method for delivering a peptide or a protein, comprising
providing a device comprising a capsule for implantation into the body, said capsule comprising a first end, a second end and a fluid impermeable wall extending from the first end to the second end to define a reservoir; said capsule further comprising an exit port in communication with the reservoir and a nanopore membrane in communication with the exit port, wherein said device comprises a peptide or a protein in the reservoir, said peptide or protein having a Stoke's diameter, and wherein said nanopore membrane has pores between about 1-5 times the Stoke's diameter of the peptide or protein, and wherein an amount of the peptide or protein is contained in the reservoir for release at a rate that approaches zero-order release for a period of several weeks.
2. The method of claim 1 , wherein said nanopore membrane comprises an array of parallel, annular channels.
3. The method of claim 2 , wherein channels in the array of parallel, annular channels have a pore size of between 2-100 nm.
4. The method of claim 1 , wherein said nanopore membrane comprises an array of parallel, rectangular channels.
5. The method of claim 4 , wherein channels in the array of parallel, rectangular channels have a width of between 2-100 nm.
6. The method of claim 1 , wherein the peptide or protein is dispersed within said reservoir as an aqueous solution or aqueous suspension.
7. The method of claim 1 , wherein the peptide or protein is in dry form.
8. The method of claim 1 , wherein the peptide or protein is a hormone, a hormone agonist or a hormone antagonist.
9. The method of claim 1 , wherein the peptide or protein is a growth hormone or a cytokine.
10. The method of claim 1 , wherein the peptide or protein is an immune modulator.
11. The method of claim 1 , wherein the peptide or protein is an anti-infective or an anti-inflammatory.
12. The method of claim 1 , wherein the device comprises an internal volume of about 250 μL to about several mLs.
13. The method of claim 1 , wherein the device is about 45-100 mm in length.