Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
1. A pipette tip comprising a proximal region and a distal region, wherein:
the proximal region comprises an exterior surface and an annular flange at the proximal terminus of the proximal region;
the proximal region comprises an annular groove on the interior surface;
the proximal region comprises a first set of axially oriented ribs and a second set of axially oriented ribs;
the ribs of the first set and the second set are circumferentially spaced and alternately spaced around the exterior surface of the proximal region; and
ribs of the first set have a maximum thickness greater than the maximum thickness of ribs of the second set.
2. The pipette tip of claim 1 , wherein the proximal region comprises an annular flange at the proximal terminus of the proximal region.
3. The pipette tip of claim 1 , wherein one end of ribs in the first set, of ribs in the second set, or of ribs in the first set and the second set is co-extensive with, or terminates at, the flange.
4. The pipette tip of claim 1 , wherein one end of ribs in the first set, of ribs in the second set, or of ribs in the first set and the second set is co-extensive with, or terminates at, the junction between the flange and the proximal region.
5. The pipette tip of claim 1 , wherein one end of ribs in the first set, of ribs in the second set, or of ribs in the first set and the second set is co-extensive with, or terminates at, the junction between the proximal region and the distal region.
6. The pipette tip of claim 1 , wherein of ribs in the first set, of ribs in the second set, or of ribs in the first set and the second set extend from the junction of the flange and proximal region to the junction of the proximal and distal regions.
7. The pipette tip of claim 1 , wherein the exterior surface of the distal region comprises a step.
8. The pipette tip of claim 1 , wherein each rib of the first set alternates with each rib of the second set.
9. The pipette tip of claim 1 , wherein the thickness at or near the proximal terminus of the distal region is substantially similar to the thickness at or near the distal terminus of the proximal region.
10. The pipette tip of claim 1 , wherein the maximum thickness of the ribs is about 0.037 inches to about 0.060 inches.
11. The pipette tip of claim 1 , wherein the maximum thickness of the ribs is about 0.016 inches to about 0.027 inches.
12. The pipette tip of claim 1 , wherein the maximum thickness of the ribs is about 0.015 inches to about 0.025 inches.
13. The pipette tip of claim 1 , wherein the maximum thickness of the ribs is about 0.011 to about 0.021 inches.
14. The pipette tip of claim 1 , wherein the maximum thickness of the second set of ribs is about 0.003 inches to about 0.009 inches.
15. The pipette tip of claim 1 , wherein the first set of ribs have a maximum thickness of about 2-fold to about 10-fold greater than the maximum thickness of the second set of ribs.
16. The pipette tip of claim 1 , wherein the proximal region comprises a sealing zone.
17. The pipette tip of claim 16 , wherein the ribs or portion thereof extend over the sealing zone.
18. The pipette tip of claim 16 , wherein the sealing zone is located at a position in the pipette tip interior proximal of the annular groove.
19. The pipette tip of claim 16 , wherein the sealing zone is located at a position in the pipette tip interior distal of the annular groove.
20. The pipette tip of claim 16 , wherein the maximum thickness of a rib is about 1.2-fold to about 7-fold greater than the wall thickness of the pipette tip at or near the sealing zone.