Methods and compositions for interfering with extraction or conversion of a drug susceptible to abuse

1. An immediate release therapeutic composition comprising:

a pharmaceutically effective amount of pseudoephedrine or a salt thereof;

a triglyceride in an amount of about 1 wt % to about 50 wt % of the therapeutic composition;

hydroxypropylcellulose;

polyethylene oxide; and

a disintegrant selected from the group consisting of crospovidone, sodium starch glycolate and croscarmellose sodium.

2. The therapeutic composition of claim 1 , wherein the hydroxypropylcellulose has a viscosity of about 1,500 mPa to about 3,000 mPa at a concentration of 1% in water.

3. The therapeutic composition of claim 1 , wherein the hydroxypropylcellulose has a molecular weight of about 1,150,000.

4. The therapeutic composition of claim 1 , wherein the polyethylene oxide is present in an amount of about 3 wt % to about 7 wt %.

5. The therapeutic composition of claim 1 , wherein the polyethylene oxide is present in an amount of about 5 wt % to about 10 wt %.

6. The therapeutic composition of claim 1 , wherein the triglyceride has a melting point of about 50° C. to about 80° C.

7. The therapeutic composition of claim 1 , wherein the triglyceride is tristearin.

8. The therapeutic composition of claim 1 , wherein the disintegrant is crospovidone and is present in an amount of about 15 wt % to about 25 wt %.

9. The therapeutic composition of claim 1 , wherein the disintegrant is crospovidone and is present in an amount of about 18 wt % to about 22 wt %.

10. The therapeutic composition of claim 1 , further comprising a glidant.

11. The therapeutic composition of claim 10 , wherein the glidant comprises colloidal silicon dioxide.

12. The therapeutic composition of claim 1 , further comprising a lubricant.

13. The therapeutic composition of claim 12 , wherein the lubricant comprises magnesium stearate.

14. The therapeutic composition of claim 1 , wherein the composition is a suppository, capsule, caplet, pill, gel, soft gelatin capsule, or compressed tablet form.

15. The therapeutic composition of claim 1 , wherein the composition is in unit dose form.

16. An immediate release composition suitable for reducing the chemical conversion of a precursor compound included in the composition to a drug susceptible to abuse comprising:

a precursor compound that can be used in a chemical synthesis of a drug that is susceptible to abuse;

a triglyceride in an amount of about 1 wt % to about 50 wt % of composition;

hydroxypropylcellulose;

polyethylene oxide; and

a disintegrant selected from the group consisting of crospovidone, sodium starch glycolate and croscarmellose sodium.

17. The composition of claim 16 , wherein the precursor compound comprises pseudoephedrine.

18. The therapeutic composition of composition of claim 15 , wherein the unit dose form is a direct compressed unit dose form.

19. A method of making an immediate release composition suitable for reducing the chemical conversion of precursor compound included in the composition to a drug susceptible to abuse comprising:

providing ingredients comprising: a precursor compound that can be used in a chemical synthesis of a drug that is susceptible to abuse; a triglyceride in an amount of about 1 wt % to about 50 wt % of composition, hydroxypropylcellulose; polyethylene oxide, and a disintegrant selected from the group consisting of crospovidone, sodium starch glycolate, and croscarmellose sodium; and

directly compressing the ingredients into a unit dose form.