IP Library Granted Patent US 10,271,817
Granted Patent B2
US 10,271,817 · App. 14/735,203 · Granted Apr 30, 2019

Valve regurgitant detection for echocardiography

Inventors: Ingmar Voigt (Erlangen, DE); Tommaso Mansi (Plainsboro, NJ); Bogdan Georgescu (Plainsboro, NJ); Helene C Houle (San Jose, CA); Dorin Comaniciu (Princeton Junction, NJ); Codruta-Xenia Ene (Prahova, RO); Mihai Scutaru (Brasov, RO)
Assignee: Siemens Medical Solutions USA, Inc.
A61B8/065A61B8/0883A61B8/14A61B8/463A61B8/488A61B8/5223A61B8/5238G06T7/0012G06T19/00A61B8/12G06T2207/10132G06T2207/20081G06T2207/30048G06T2210/41
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Quick Facts
Patent No.
US 10,271,817
App. No.
14/735,203
Granted
Apr 30, 2019
Kind
B2
Abstract

A regurgitant orifice of a valve is detected. The valve is detected from ultrasound data. An anatomical model of the valve is fit to the ultrasound data. This anatomical model may be used in various ways to assist in valvular assessment. The model may define anatomical locations about which data is sampled for quantification. The model may assist in detection of the regurgitant orifice using both B-mode and color Doppler flow data with visualization without the jet. Segmentation of a regurgitant jet for the orifice may be constrained by the model. Dynamic information may be determined based on the modeling of the valve over time.

Claims (33)

1. A method for detecting a regurgitant point in echocardiography, the method comprising:

detecting, by a processor, a valve with a first machine-learnt classifier using input first features from both B-mode and flow-mode data for a patient;

fitting, by the processor, a model of the valve to the detected valve of the patient;

detecting, by the processor, the regurgitant point with a second machine-learnt classifier using second features from both the B-mode and the flow-mode data, the second machine-learnt classifier being applied only to locations along a free edge of the model as fit to the valve;

segmenting, by the processor, regurgitant jet image data of a regurgitant jet using the regurgitant point as a seed point; and

outputting an image including the B-mode data, the flow-mode data, the model as fit to the valve, and the regurgitant jet image data as segmented.

2. The method of claim 1 wherein detecting the valve comprises detecting a location, orientation, and scale of the valve represented by the B-mode data.

3. The method of claim 1 wherein fitting the model comprises fitting an annulus, leaflets, free edge, or combinations thereof.

4. The method of claim 1 wherein fitting the model comprises transforming a statistical shape model as a function of the detected valve.

5. The method of claim 1 wherein detecting with the first and second machine-learnt classifiers comprises calculating Haar, steerable, or Haar and steerable feature values for the B-mode data and for the flow-mode data.

6. The method of claim 1 further comprising calculating the quantity from sample planes positioned relative to the detected valve.

7. The method of claim 1 wherein segmenting comprises applying a random walker for the flow-mode data while using the regurgitant point to spatially limit the segmentation of the regurgitant jet.

8. The method of claim 1 wherein outputting further comprises outputting a quantity as representing the regurgitant jet.

9. The method of claim 1 further comprising repeating the detecting the valve, fitting, detecting the regurgitant point, and segmenting for different times in a cardiac cycle.

10. The method of claim 1 further comprising:

scanning, with a transducer adjacent the patient, a cardiac region of the patient with ultrasound;

detecting, with a B-mode detector and in response to the scanning, the B-mode data representing tissue in the cardiac region;

estimating, with a flow estimator and in response to the scanning, the flow-mode data representing fluid in the cardiac region, the flow-mode data comprising energy, velocity, or energy and velocity.

11. The method of claim 1 wherein detecting the valve comprises constraining the model as fit to the valve or part of the model as fit to the valve to locations without flow-mode data.

12. In a non-transitory computer readable storage medium having stored therein data representing instructions executable by a programmed processor for detecting a regurgitant orifice, the storage medium comprising instructions for:

detecting, at different times, anatomy of a heart valve from first features derived from both B-mode and color flow Doppler data;

sampling, at the different times, transvalvular flow over time from the color flow Doppler data on sampling planes positioned relative to the detected heart valves for the different times;

calculating a quantity of transvalvular flow from the sampling;

fitting a model of the heart valve to the detected anatomy of the heart valve;

detecting the regurgitant orifice from second features from both the color flow Doppler data and from the B-mode data, by applying a machine-learnt classifier only to locations along a free edge of the model as fit to the heart valve;

segmenting a regurgitant jet for the heart valve using the regurgitant orifice as a seed point; computing a clinical biomarker for the regurgitant jet; and

providing a visualization of the anatomy of the heart valve including the clinical biomarker and the quantity of transvalvular flow.

13. The non-transitory computer readable storage medium of claim 12 wherein detecting the anatomy comprises detecting aortic, mitral, pulmonary, or tricuspid anatomy.

14. The non-transitory computer readable storage medium of claim 12 further comprising computing dynamic flow quantity for flow as a function of time from the sampling.

15. The non-transitory computer readable storage medium of claim 12 further comprising displaying the model as fit to the heart valve and the regurgitant orifice without the regurgitant jet.

16. A system for detecting a regurgitant region, the system comprising:

an ultrasound scanner configured to scan a heart volume of a patient, the scan providing B-mode and Doppler flow data;

a processor configured to fit a model of a heart valve over time to the B-mode data using the B-mode data and the Doppler flow data, and use the model as fit to the heart valve to locate the regurgitant region over time by applying a machine-learnt classifier only to locations along a free edge of the model as fit to the heart valve; and a display configured to generate a visualization of the model as fit to the heart valve over time and highlight the regurgitant region without displaying flow data for a regurgitant jet.

Assignments (14)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE PREVIOUSLY RECORDED AT REEL: 066088 FRAME: 0256. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jan 17, 2024
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 071178/0246 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2023
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 066088/0256 →
CORRECTIVE ASSIGNMENT TO CORRECT THE DATE OF EXECUTION OF CONVEYING PARTY PREVIOUSLY RECORDED ON REEL 055126 FRAME 0119. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 4, 2021
From: SIEMENS MEDICAL SOLUTIONS USA, INC.
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 055220/0177 →
CORRECTIVE ASSIGNMENT TO CORRECT THE DATE OF EXECUTION OF CONVEYING PARTY PREVIOUSLY RECORDED ON REEL 055126 FRAME 0246. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 4, 2021
From: SIEMENS AKTIENGESELLSCHAFT
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 055220/0140 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2021
From: SIEMENS CORPORATION
To: SIEMENS MEDICAL SOLUTIONS USA, INC.
Reel/Frame 055126/0066 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2021
From: SIEMENS MEDICAL SOLUTIONS USA, INC.
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 055126/0119 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2021
From: SIEMENS AKTIENGESELLSCHAFT
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 055126/0246 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2017
From: SIEMENS AKTIENGESELLSCHAFT
To: SIEMENS MEDICAL SOLUTIONS USA, INC.
Reel/Frame 043092/0562 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2017
From: SIEMENS CORPORATION
To: SIEMENS MEDICAL SOLUTIONS USA, INC.
Reel/Frame 043092/0737 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 13, 2017
From: SIEMENS S.R.L.
To: SIEMENS CORPORATION
Reel/Frame 043000/0427 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 29, 2016
From: HOULE, HELENE C.
To: SIEMENS MEDICAL SOLUTIONS USA, INC.
Reel/Frame 037850/0278 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 19, 2016
From: COMANICIU, DORIN; GEORGESCU, BOGDAN; MANSI, TOMMASO; ENE, CODRUTA-XENIA
To: SIEMENS CORPORATION
Reel/Frame 037777/0709 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 10, 2016
From: SCUTARU, MIHAI
To: SIEMENS S.R.L.
Reel/Frame 037695/0128 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 10, 2016
From: VOIGT, INGMAR
To: SIEMENS AKTIENGESELLSCHAFT
Reel/Frame 037694/0946 →
Continuity (2)
Provisional Application 62015671 · Jun 23, 2014
Related Publication 20150366532A1 · Dec 24, 2015
Cited By (3)
US 12,329,565 US 12,635,973 US 12,653,490