IP Library Granted Patent US 10,248,765
Granted Patent B1
US 10,248,765 · App. 14/737,412 · Granted Apr 2, 2019

Systems, devices, and methods for bodily fluid sample collection, transport, and handling

Inventors: Elizabeth A. Holmes (Palo Alto, CA); Clarissa Lui (Palo Alto, CA); Michael Chen (Palo Alto, CA); Daniel Young (Palo Alto, CA); Adrit Lath (Sunnyvale, CA); Zachary Morrison (San Francisco, CA); Brian Argyres (San Mateo, CA); William Westrick (Palo Alto, CA)
Assignee: Theranos IP Company, LLC
G06F19/366A61B5/1411A61B5/151A61B5/150022A61B5/150251A61B5/150351A61B5/150755A61B5/150786G06Q10/0832
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Quick Facts
Patent No.
US 10,248,765
App. No.
14/737,412
Granted
Apr 2, 2019
Kind
B1
Abstract

Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample vessel for receiving the bodily fluid sample collected in the sample collection channel, the sample vessel operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the vessel and/or another source provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the vessel.

Claims (42)

1. A method for use with a bodily fluid sample from a subject, the method comprising:

shipping a plurality of sample containers from a first location to a second location, wherein each of said sample containers contains a microsample of about 500 uL or less and wherein interior volume of each of the sample containers is about 600 uL or less,

wherein shipping of the plurality of samples containers is accomplished using a first frame sized to fit in a shipping container, said first frame comprises a plurality of openings each sized and shaped to engage at least one of the sample containers and hold the sample containers in a desired orientation;

obtaining data from each of the sample containers;

providing a plurality of processing frames at the second location;

using said data from the sample containers to determine which of said processing frames receive which of said sample containers and provide sorting information for the sample containers; and

moving said sample containers from the shipping frame to the processing frame based on data provided by the sample containers and based on said sorting information; and

handling the processing frame to simultaneously process the sample containers in the processing frame.

2. The method of claim 1 wherein each of the sample containers further comprises at least one sample container information storage unit, wherein obtaining data from the sample containers comprises simultaneously scanning a plurality of sample container information storage units simultaneously.

3. The method of claim 2 wherein said scanning occurs when the containers are in the shipping frame.

4. The method of claim 2 wherein said scanning comprises scanning an underside surface of each of the sample containers.

5. The method of claim 1 further comprising providing at least one database at a server, wherein determining which processing frames receive which of the sample containers comprises referencing the data with said at least one database at said server.

6. The method of claim 1 further comprising providing at least one database of subject identifiers at a server, wherein said data from the sample containers comprise at least one sample container identifier, and wherein said determining comprises matching said at least one sample container identifier with at least one of said subject identifiers.

7. The method of claim 1 further comprising providing a plurality of sample container processing procedures wherein said data from the sample containers comprise at least one sample container identifier, and wherein said determining comprises matching said at least one sample container identifier with one of said sample container processing procedures.

8. The method of claim 1 wherein at least some of the sample containers contain sample having a first anticoagulant and at least some other of the sample containers have a second, different anticoagulant.

9. The method of claim 1 wherein moving said sample containers comprises using a robotic manipulator.

10. A method for use with a bodily fluid sample from a subject, the method comprising:

shipping a plurality of sample containers from a first location to a second location, wherein each of said sample containers contains a microsample of about 500 uL or less and wherein interior volume of each of the sample containers is about 600 uL or less,

wherein shipping of the plurality of samples containers is accomplished using a first frame sized to fit in a shipping container, said first frame comprises a plurality of openings each sized and shaped to engage at least one of the sample containers and hold the sample containers in a desired orientation;

obtaining data from each of the sample containers;

providing a plurality of processing frames at the second location;

using said data from the sample containers to determine which of said processing frames receive which of said sample containers and provide sorting information for the sample containers; and

moving said sample containers from the shipping frame to the processing frame based on data provided by the sample containers and based on said sorting information; and

handling the processing frame to simultaneously process the sample containers in the processing frame,

wherein at least one of said sample containers from the subject contains sample having a first anticoagulant and at least another of the sample containers from the subject has a second, different anticoagulant.

11. The method of claim 10 wherein each of the sample containers further comprises at least one sample container information storage unit, wherein obtaining data from the sample containers comprises simultaneously scanning a plurality of sample container information storage units simultaneously.

12. The method of claim 11 wherein said scanning occurs when the containers are in the shipping frame.

13. The method of claim 11 wherein said scanning comprises scanning an underside surface of each of the sample containers.

14. The method of claim 10 further comprising providing at least one database at a server, wherein determining which processing frames receive which of the sample containers comprises referencing the data with said at least one database at said server.

15. The method of claim 10 wherein moving said sample containers comprises using a robotic manipulator.

16. A method for use with a bodily fluid sample from a subject, the method comprising:

shipping a plurality of sample containers from a first location to a second location, wherein each of said sample containers contains a microsample of about 500 uL or less and wherein interior volume of each of the sample containers is about 600 uL or less,

wherein shipping of the plurality of samples containers is accomplished using a first frame sized to fit in a shipping container, said first frame comprises a plurality of openings each sized and shaped to engage at least one of the sample containers and hold the sample containers in a desired orientation;

obtaining data from each of the sample containers;

providing a plurality of processing frames at the second location;

using said data from the sample containers to determine which of said processing frames receive which of said sample containers and provide sorting information for the sample containers; and

moving said sample containers from the shipping frame to the processing frame based on data provided by the sample containers and based on said sorting information; and

handling the processing frame to simultaneously process the sample containers in the processing frame at a processing frame centrifuge.

17. The method of claim 16 wherein at least some of the sample containers contain sample having a first anticoagulant and at least some other of the sample containers have a second, different anticoagulant.

18. The method of claim 16 wherein at least one of said sample containers from the subject contains sample having a first anticoagulant and at least another of the sample containers from the subject has a second, different anticoagulant.

19. The method of claim 16 wherein moving said sample containers comprises using a robotic manipulator.

20. The method of claim 16 wherein each of the sample containers further comprises at least one sample container information storage unit, wherein obtaining data from the sample containers comprises simultaneously scanning a plurality of sample container information storage units simultaneously.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 8, 2020
From: ARGYRES, BRIAN; LATH, ADRIT; WESTWICK, WILLIAM; MORRISON, ZACHARY
To: THERANOS, INC.
Reel/Frame 052351/0260 →
CHANGE OF NAME Recorded Apr 3, 2020
From: THERANOS IP COMPANY, LLC
To: LABRADOR DIAGNOSTICS LLC
Reel/Frame 052313/0011 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2018
From: THERANOS, INC.
To: THERANOS IP COMPANY, LLC
Reel/Frame 045075/0310 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2017
From: THERANOS INC.
To: THERANOS IP COMPANY, LLC
Reel/Frame 044838/0909 →
SECURITY INTEREST Recorded Dec 12, 2017
From: THERANOS IP COMPANY, LLC
To: FORTRESS CREDIT CORP.
Reel/Frame 044839/0568 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 28, 2017
From: LUI, CLARISSA; YOUNG, DANIEL; HOLMES, ELIZABETH A.; CHEN, MICHAEL
To: THERANOS, INC.
Reel/Frame 044242/0106 →
Continuity (28)
Continuation In Part 14098177 · Dec 5, 2013
Continuation In Part 14446080 · Jul 29, 2014
Continuation PCTUS2013000268 · Dec 5, 2013
Continuation In Part 29466440 · Sep 8, 2013
Continuation In Part 29466441 · Sep 8, 2013
Continuation In Part 29466442 · Sep 8, 2013
Continuation In Part 29466443 · Sep 8, 2013
Continuation In Part 29466710 · Sep 10, 2013
Continuation In Part 29466440 · Sep 8, 2013
Continuation In Part 29466441 · Sep 8, 2013
Continuation In Part 29466739 · Sep 11, 2013
Continuation In Part 29466442 · Sep 8, 2013
Continuation In Part 29466443 · Sep 8, 2013
Continuation In Part 14737412
Continuation In Part 14447099 · Jul 30, 2014
Continuation In Part PCTUS2013000268 · Dec 5, 2013
Continuation In Part 29466440 · Sep 8, 2013
Continuation In Part 29466441 · Sep 8, 2013
Continuation In Part 29466442 · Sep 8, 2013
Continuation In Part 29466443 · Sep 8, 2013
Continuation In Part 29466710 · Sep 10, 2013
Continuation In Part 29466739 · Sep 11, 2013
Provisional Application 61733886 · Dec 5, 2012
Provisional Application 62011023 · Jun 11, 2014
Provisional Application 61852489 · Mar 15, 2013
Provisional Application 61786351 · Mar 15, 2013
Provisional Application 61875030 · Sep 7, 2013
Provisional Application 61875107 · Sep 8, 2013
Cited By (6)
US 1,064,308 US 1,073,110 US 1,108,656 US 12,214,346 US 12,440,133 US 12,446,810