IP Library Patent Application 14739770
Patent Application
App. No. 14/739,770

Novel Epitope for Switching to TH1 Cell and Use Thereof

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Quick Facts
Patent No.
US None
App. No.
14/739,770
Abstract

The present invention relates to a novel epitope that converts T cell to type 1 helper T (T H 1) cell. Specifically, the present invention relates to an epitope constituting the 56 th to 65 th amino acids (SEQ ID No.2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to T H 1 cell and a method for converting T cell to T H 1 cell, a pharmaceutical composition comprising the antibody for preventing or treating cancer, a method for treating cancer using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.

Claims (2)

1 . A polypeptide defined by an amino acid sequence of SEQ ID No. 2, which is an epitope of activation-inducible tumor necrosis factor receptor (AITR), for converting T cell to type 1 helper T (T H 1) cell.

2 . A polynucleotide encoding the polypeptide of claim 1 .

Assignments (2)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 9, 2017
From: NATIONAL CANCER CENTER
To: EUTILEX CO., LTD.
Reel/Frame 041215/0798 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2015
From: KWON, BYOUNG SE
To: NATIONAL CANCER CENTER
Reel/Frame 037661/0371 →