Use of cannabinoids in the treatment of epilepsy
View Patent ↗The present disclosure relates to the use of cannabidiol (CBD) for the reduction of total convulsive seizure frequency in the treatment of “treatment-resistant epilepsy” (TRE). In particular, the disclosure relates to the use of CBD of treating TRE when the TRE is Dravet syndrome; myoclonic absence seizures or febrile infection related epilepsy syndrome (FIRES). The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).
1. A method of treating treatment-resistant epilepsy comprising administering cannabidiol (CBD) to a subject, wherein the epilepsy is febrile infection related epilepsy syndrome (FIRES).
2. The method of claim 1 , wherein the CBD is administered in combination with more at least one concomitant anti-epileptic drug (AED).
3. The method of claim 2 , wherein the seizure type to be treated is a complex partial seizure (focal seizure with impairment).
4. The method of claim 1 , wherein the CBD is a highly purified extract of cannabis which comprises at least 98% (w/w) CBD.
5. The method of claim 2 , wherein the number of AED that are used in combination with the CBD in treatment are reduced relative to the number of AED prior to treatment with the CBD.
6. The method of claim 2 , wherein the dose of AED that are used in combination with the CBD in treatment is reduced relative to the dose of AED prior to treatment with the CBD.
7. The method of claim 6 , wherein the AED is clobazam.
8. The method of claim 1 , wherein the dose of CBD is from 5 mg/kg/day to 25 mg/kg/day.