IP Library › Granted Patent US 9,597,274
Granted Patent B2
US 9,597,274 · App. 14/742,060 · Granted Mar 21, 2017

Peptides and their use in the treatment of skin

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Quick Facts
Patent No.
US 9,597,274
App. No.
14/742,060
Granted
Mar 21, 2017
Kind
B2
Abstract

Peptides (and derivatives thereof), topical compositions, and methods of diminishing signs of aging and/or improving health of human integuments are provided. The peptides are derived from human Growth Differentiation Factor 11 (GDF-11).

Claims (5)

1. A method for diminishing the appearance of dermatological signs of aging comprising topically applying to the skin in need thereof a composition comprising, in a topically acceptable vehicle, an active agent comprising a GDF-11 peptide fragment consisting of the sequence LRLK (SEQ ID NO: 453), MVV (SEQ ID NO: 369), or QILSKLRL (SEQ ID NO: 2028), and/or C 1-24 aliphatic derivatives thereof.

2. The method according to claim 1 , wherein said dermatological signs of aging include fine lines and/or wrinkles.

3. The method according to claim 1 , wherein said active agent increases collagen production in skin.

4. The method according to claim 1 , wherein said active agent increases hyaluronic acid production in skin.

5. The method according to claim 1 , wherein said composition is applied at least once daily for at least eight weeks.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Jan 28, 2026
From: NATURA &CO LUXEMBOURG HOLDINGS S.À R.L., AS A SECURED PARTY; NATURA &CO UK HOLDINGS LIMITED, AS A SECURED PARTY
To: AVON PRODUCTS, INC.
Reel/Frame 074508/0281 →
RELEASE OF SECURITY INTEREST Recorded Dec 11, 2024
From: NATURA &CO HOLDING S.A.; NATURA COSMETICOS S.A.; NATURA &CO LUXEMBOURG HOLDINGS S.A R.L. - LUXEMBOURG; NATURA &CO UK HOLDINGS LIMITED - UK
To: AVON PRODUCTS, INC
Reel/Frame 069591/0494 →
PATENT SECURITY AGREEMENT Recorded Aug 16, 2024
From: AVON PRODUCTS, INC.
To: NATURA &CO HOLDING S.A.; NATURA &CO LUXEMBOURG HOLDINGS S.À R.L.; NATURA COSMÉTICOS S.A.; NATURA &CO UK HOLDINGS LIMITED
Reel/Frame 068659/0915 →
SECURITY INTEREST Recorded Apr 29, 2024
From: AVON PRODUCTS, INC.; MI HOLDINGS, INC.; AVON INTERNATIONAL OPERATIONS, INC.; AVON CAPITAL CORPORATION; AVON COSMETICS LIMITED; AVON BEAUTY LIMITED
To: NATURA &CO HOLDING S.A., AS SECURED PARTY; NATURA &CO LUXEMBOURG HOLDINGS S.À R.L., AS A SECURED PARTY; NATURA COSMÉTICOS S.A., AS A SECURED PARTY
Reel/Frame 067249/0491 →
SECURITY INTEREST Recorded Aug 11, 2023
From: AVON PRODUCTS, INC.
To: NATURA &CO LUXEMBOURG HOLDINGS S.À R.L., AS A SECURED PARTY; NATURA &CO UK HOLDINGS LIMITED, AS A SECURED PARTY
Reel/Frame 064566/0872 →
SECURITY INTEREST Recorded Nov 14, 2019
From: AVON PRODUCTS, INC.
To: CITIBANK, N.A., LONDON BRANCH
Reel/Frame 051032/0210 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2015
From: IDKOWIAK-BALDYS, JOLANTA; LYGA, JOHN W.; SANTHANAM, UMA
To: AVON PRODUCTS, INC.
Reel/Frame 035997/0732 →