Compounds that modulate intracellular calcium
View Patent ↗Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
1. A compound of Formula (VI) having the structure:
wherein:
R′ 1 is,
L 2 is —NH—C(═O)—, or —C(═O)NH—;
Y is independently selected from CR 9 or N;
R 2 is phenyl, pyridyl, benzoxazolyl, or thiadiazolyl; wherein phenyl, pyridyl, benzoxazolyl, or thiadiazolyl is optionally substituted with at least one R 3 ;
R 3 is independently selected from H, F, D, Cl, Br, I, —CN, —NO 2 , —OH, —CF 3 , —OCF 3 , —OR 5 , C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 1 -C 6 haloalkyl,
n is an integer selected from 0-3;
R 9 is independently selected from H, D, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OR 5 , —OCF 3 , C 1 -C 6 carbonylalkyl, or —CF 3 ;
R 10 is selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OR 5 , —OCF 3 , C 1 -C 6 carbonylalkyl, or —CF 3 ;
R 5 is independently selected from H, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl;
or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.
2. A compound selected from:
or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.
3. A pharmaceutical composition comprising a pharmaceutically acceptable diluent, excipient or binder, and a compound of claim 1 or pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.
4. The compound of claim 1 wherein R′1 is
5. The compound of claim 1 wherein R′ 1 is
6. The compound of claim 1 wherein L 2 is —NH—C(═O)—.
7. The compound of claim 1 wherein Y is CR 9 .
8. The compound of claim 7 wherein R 9 is H.
9. The compound of claim 1 wherein n is 0.
10. The compound of claim 1 wherein R 2 is phenyl optionally substituted with at least one R 3 .
11. The compound of claim 1 wherein R 2 is benzoxaolyl optionally substituted with at least one R 3 .
12. The compound of claim 11 wherein heteroaryl is pyridine.
13. The compound of claim 11 wherein heteroaryl is thiadiazole.
14. The compound of claim 10 wherein R 3 is halogen.