Fluid analysis sheet, fluid analysis cartridge including the same, and method of manufacturing fluid analysis cartridge
Provided is a fluid analysis cartridge configured to analyze a fluid specimen, a fluid analysis sheet forming the same and a method of manufacturing the fluid analysis cartridge. The fluid analysis sheet includes at least one cut out part configured to form an intermediate layer of an inspection substrate, the cut out part including a flow passage structure including an inlet part in which a fluid is introduced and an inspection part in which the fluid is introduced to react with a reagent; and wherein the cut out part is further configured to include a first end adjacent to the inspection part and a second end adjacent to the inlet part, and wherein a minimum distance between the first end and the flow passage structure is at least 1 mm.
1. A fluid analysis sheet comprising:
at least one cut out part configured to form an intermediate layer of an inspection substrate, the cut out part comprising:
a flow passage structure including an inlet part in which a fluid is introduced, and an inspection part in which the fluid is introduced to react with a reagent; and
wherein the cut out part is further configured to include a first end adjacent to the inspection part and a second end adjacent to the inlet part, and
wherein a minimum distance between the first end and the inspection part of the flow passage structure is at least 1 mm, and wherein the minimum distance is the smallest straight line distance between the first end and any part of the flow passage structure where the fluid is introduced to react with a reagent.
2. The fluid analysis sheet of claim 1 , wherein the first end comprises at least one dent part oriented toward the second end.
3. The fluid analysis sheet of claim 2 , wherein the dent part is formed to have a pattern.
4. The fluid analysis sheet of claim 2 , wherein the dent part is formed in a circular shape.
5. The fluid analysis sheet of claim 2 , wherein the dent part is formed in a quadrangular shape.
6. The fluid analysis sheet of claim 1 , wherein the first end comprises a first contact part formed in a curved shape and a second contact part formed in a linear shape.
7. The fluid analysis sheet of claim 6 , wherein a minimum distance between the first contact part and the flow passage structure is at least 1 mm.
8. The fluid analysis sheet of claim 6 , wherein a minimum distance between the second contact part and the flow passage structure is at least 2 mm.
9. The fluid analysis sheet of claim 1 , wherein the fluid analysis sheet has a surface which is coated with a hydrophobic solution to prevent a hydrophilic fluid from being spread therein.
10. The fluid analysis sheet of claim 1 , comprising a plurality of the cut out part arranged in at least one of: two columns and two rows.
11. The fluid analysis sheet of claim 1 , wherein the fluid analysis sheet formed from a porous material.
12. A fluid analysis cartridge comprising:
a housing including at least one supplying hole to supply a fluid specimen; and
an inspection substrate coupled to the housing such that the fluid specimen introduced through the supplying hole is introduced to be inspected,
wherein the inspection substrate comprises;
an upper layer located at an upper side;
a lower layer located at a lower side; and
an intermediate layer located between the upper layer and the lower layer, and coupled to the upper layer and the lower layer such that at least a portion of outermost ends of the intermediate layer are located inside with respect to an edge of the upper layer and an edge of the lower layer.
13. The fluid analysis cartridge of claim 12 , wherein the intermediate layer has a flow passage structure that includes an inlet part in which a fluid is introduced; and
an inspection part in which the fluid is introduced to react with a reagent.
14. The fluid analysis cartridge of claim 13 , wherein the first end of the intermediate layer is adjacent to the inspection part, and the first end is provided with a dent part oriented such that at least a portion of the dent part is dented inward from the first end.
15. The fluid analysis cartridge of claim 14 , wherein the dent part is formed to have a pattern.
16. The fluid analysis cartridge of claim 15 , wherein the dent part is formed in a circular shape and a minimum distance between the dent part and the flow passage structure is at least 1 mm.
17. The fluid analysis cartridge of claim 15 , wherein the dent part is formed in a quadrangular shape and a minimum distance between the dent part and the flow passage structure is at least 2 mm.
18. The fluid analysis cartridge of claim 12 , wherein a surface of the intermediate layer is coated with a hydrophobic solution to prevent a hydrophilic fluid from being spread therein.
19. The fluid analysis cartridge according to claim 12 , wherein the intermediate layer is formed from a porous material; and
the upper layer and the lower layer are formed from a chemically and biologically inactive film.
20. A method of manufacturing a fluid analysis cartridge comprising: an inspection substrate in which a fluid is inspected, the inspection substrate including an upper layer, an intermediate layer and a lower layer, and the fluid analysis cartridge further including a housing coupled to the inspection substrate, the method comprising;
moving a fluid analysis sheet constituting the intermediate layer of the inspection substrate from a main roll;
performing first and second coating processes to coat the fluid analysis sheet with a hydrophobic solution;
attaching an upper film constituting the upper layer, the fluid analysis sheet constituting the intermediate layer and a lower film constituting the lower layer to each other to form a coupled body;
cutting out the coupled body to form one inspection substrate; and
coupling the housing to the inspection substrate, wherein the coupled body is cut off such that the intermediate layer is located inside with respect to at least one outermost edge of the upper layer and at least one edge of the lower layer.
21. The method of claim 20 , wherein the fluid analysis sheet is wound around a first coating roll and a second coating roll when at least one of the first and second coating processes is performed.
22. The method of claim 20 , comprising performing a first drying process and a second drying process after each of the first and second coating process is performed.
23. The method of claim 20 , wherein, the hydrophobic solution comprises at least one of fluorinated acrylic copolymer, fluorocarbon, silicone and a fluorocarbon-silicon coupling agent.
24. The method of claim 20 , wherein the coupled body is formed by attaching double-sided tapes on an upper surface and a lower surface of the fluid analysis sheet.
25. The method of claim 20 , wherein the intermediate layer includes a dent part oriented such that at least a portion of the dent part is dented inward from an edge so as to be formed to be located inside with respect to an edge of the upper layer and an edge of the lower layer, and the method comprises forming the dent part before the coupled body is cut.