IP Library › Granted Patent US 9,890,152

Granted Patent B2

US 9,890,152 · App. 14/745,159 · Granted Feb 13, 2018

Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants

Inventors: Marian C. Bryan (San Francisco, CA); Bryan Chan (San Carlos, CA); Emily Hanan (Redwood City, CA); Timothy Heffron (Burlingame, CA); Hans Purkey (Burlingame, CA); Richard Leonard Elliott (Harlow, GB); Robert Heald (Harlow, GB); Jamie Knight (Harlow, GB); Michael Lainchbury (Harlow, GB); Eileen M. Seward (Harlow, GB)

Assignee: GENENTECH, INC.

C07D471/04 A61K31/506 A61K31/538 A61K31/5355 A61K31/5377 A61K31/541 A61K45/06 C07D491/107 C07D498/08 C07D498/10 C07D519/00

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Quick Facts

Patent No.: US 9,890,152
App. No.: 14/745,159
Granted: Feb 13, 2018
Kind: B2

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Abstract

This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.

Claims (737)

1. A compound of Formula (I)

wherein,

X is CR 3 or N;

R 1 is C 3 -C 7 heterocycloalkyl, heteroaryl, aryl, —O(C 1 -C 6 alkyl), —O(C 3 -C 7 cycloalkyl) or —NR a R b , wherein said C 3 -C 7 heterocycloalkyl and heteroaryl may be further substituted with one to five R f groups;

R 2 is hydrogen, —(CH 2 ) m aryl, —(CH 2 ) m heteroaryl, —(CH 2 ) m C 4 -C 7 heterocycloalkyl, C 1 -C 6 alkyl, alkylamino, alkoxy or —CH 2 O(C 1 -C 3 alkyl);

R 3 is hydrogen, C 1 -C 3 alkyl, CN, COOH, C 3 -C 7 cycloalkyl, heterocycloalkyl, —NHC(O)C 1 -C 6 alkyl, (CH 2 ) m C(O)NR a R b or heteroaryl;

R 4 is hydrogen, C 3 -C 7 heterocycloalkyl, C 3 -C 7 cycloalkyl, C 1 -C 6 alkyl, —(CH 2 ) m phenyl or —(CH 2 ) m heteroaryl;

wherein each R a is independently H or C 1 -C 6 alkyl; each R b is independently H, C 1 -C 6 alkyl, alkoxy, amino, —(CH 2 ) m C 3 -C 7 cycloalkyl, —(CH 2 ) m C 3 -C 7 heteocycloalkyl or —(CH 2 ) m heteroaryl, wherein said C 3 -C 7 heterocyloalkyl and heteroaryl may be further substituted with one to three groups selected from the group consisting of halo, hydroxy, C 1 -C 3 alkyl, amino, oxo, amide, sulfonyl, sulfoxide, sulfoximinyl, alkoxy, CN and acyl; R a and R b together may form a C 3 -C 7 cycloalkyl, C 3 -C 7 heterocycloalkyl, or heteroaryl ring;

wherein each R f is independently selected from the group consisting of C 1 -C 3 alkyl, alkoxy, amino, hydroxyl, alkylamino, amide, urea, oxo, halo, pyrazolyl, imidazolyl, triazolyl, CN, NHC(O)(C 1 -C 3 alkyl), acyl, sulfonyl, sulfoxide, sulfoximinyl, sulfonamide, amide, —(CH 2 ) m C 3 -C 7 heterocycloalkyl, —O(C 1 -C 6 alkyl), —C(O)OR a ;

each m is independently 0, 1, 2 or 3;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein X is N; or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein X is CR 3 ; or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 1 , wherein R 1 is C 3 -C 7 heterocycloalkyl; on a pharmaceutically acceptable salt thereof.

5. The compound according to claim 1 , wherein R 1 is heteroaryl; or a pharmaceutically acceptable salt thereof.

6. The compound according to claim 1 , wherein R 1 is —NR a R b ; or a pharmaceutically acceptable salt thereof.

7. The compound according to claim 1 , wherein R 2 is C 1 -C 6 alkyl; or a pharmaceutically acceptable salt thereof.

8. The compound according to claim 1 , wherein R 2 is hydrogen, —(CH 2 ) m aryl, heteroaryl, C 4 -C 7 hcterocycloalkyl, alkylamino, alkoxy or —(CH 2 ) m O(C 1 -C 3 alkyl); or a pharmaceutically acceptable salt thereof.

9. The compound according to claim 1 , wherein R 4 is hydrogen or C 1 -C 6 alkyl.

10. The compound according to claim 1 , wherein R 3 is hydrogen, C 1 -C 3 alkyl, heteroaryl or —(CH 2 ) m C(O)NR a R b ; or a pharmaceutically acceptable salt thereof.

11. The compound according to claim 1 , wherein R 1 is a C 3 -C 7 heterocycloalkyl selected from the group consisting of piperidinyl, piperizinyl, pyrazolyl and pyrrolidinyl, wherein said C 3 -C 7 heterocycloalkyl may be further substituted with one to five R f groups selected from C 1 -C 6 alkyl, alkoxy, halo, hydroxy, sulfonyl, and sulfonamide; or a pharmaceutically acceptable salt thereof.

12. The compound according to claim 1 , wherein R 2 is hydrogen or C 1 -C 3 alkyl; or a pharmaceutically acceptable salt thereof.

13. The compound according to claim 10 , wherein R 3 is hydrogen, C 1 -C 3 alkyl or —C(O)NH 2 ; or a pharmaceutically acceptable salt thereof.

14. The compound according to claim 1 , wherein R 4 is hydrogen or isopropyl; R f is F, or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.

16. The compound according to claim 1 , wherein said compound is:

N-(2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

1-Isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine formate salt;

(2-Ethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

1-Isopopyl-N 6 -[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-N 2 -methyl-1H-imidazo[4,5-c]pyridine-2,6-diamine;

[2-(2-Ethoxyethoxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

[2-(2-Dimethylaminoethoxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

(2-Dimethylaminomethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine formate salt;

(1-Isopropyl-6-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-Isopropyl-2-methoxy-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)pyrimidin-4-yl]amine;

1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-ol;

8-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one;

[2-(5,6-Dihydro-8H-imidazo[1,2-a]pyrazin-7-yl)pyrimidin-4-yl]-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methanesulfonylpiperazin-1-yl)pyrimidin-4-yl]-amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(3-methoxyazetidin-1-yl)pyrimidin-4-yl]amine;

[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-[1-(tetrahydrofuran-3-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-[1-(tetrahydropyran-4-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

(1-Ethyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-[1-methyl-2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

[2-(2-Fluorobenzyl)-3-methyl-3H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-[2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]amine;

(1-Cyclopentyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-[3-methyl-2-(l H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-yl]amine dihydrochloride;

(1-Cyclopentyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxy-piperidin-1-yl)-pyrimidin-4-yl]amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(1-methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)pyrimidin-4-yl]amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-(2-morpholin-4-ylpyrimidin-4-yl)amine;

4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)thiomorpholine 1-oxide;

4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)thiomorpholine 1,1-dioxide;

3-{6-[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-ylamino]pyrrolo[3,2-c]pyridin-1-yl}-2,2-dimethylpropionamide;

((R) or (S) 1-sec-Butyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidine-3,4-diol;

N-(2-(8-Oxa-3-aza-bicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)-1-isopropyl-l H imidazo[4,5-c]pyridin-6-amine;

(R or S)—N-(2-2-oxa-7-azaspiro[4.4]nonan-7-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-N-(2-(6-(methylsulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N 4 -(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(2-(methylsulfonyl)ethyl)pyrimidine-2,4-diamine;

N 4 -(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N 2 -(1-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

1-Isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-2-(trifluoromethyl)-1H-imidazo[4,5-c]pyridin-6-amine;

N 4 -(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N 2 -(1H-pyrazol-4-yl)pyrimidine-2,4-diamine;

1-Isopropyl-N-(2-(4-(trifluoromethoxy)piperidin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-((1R,5S,6s)-6-Amino-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-N-(2-((1R,5S,6s)-6-(methylamino)-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(6,7-Dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

((1R,5 S,6r)-3-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-azabicyclo[(3.1.0]hexan-6-yl)methanol;

1-isopropyl-N-(2-((I R,5S,6r)-6-(methoxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N 2 -(1-Benzyl-1H-pyrazol-3-yl)-N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

3-((4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)tetrahydrothiophene 1,1-dioxide;

6-((2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide; or

N-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine.

17. The compound according to claim 1 , wherein said compound is:

1-Isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-N-(2-(6-methoxypyridin-3-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2′-Ethoxy-[2,5′-bipyrimidin]-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(4-Isopropoxypiperidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-Ethyl-1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-Isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carbonitrile;

1-Isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

6-((2-(6,7-Dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N-methyl-1H-imidazole-4-carboxamide;

5-(4-((1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)pyridin-2-ol;

N-(2-(1H-Imidazol-1-yl)ethyl)-1-isopropyl6(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-Ethyl-1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-carboxamide;

1-isopropyl-N-(2-(3-methoxypyrrolidin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino) pyrimidin-2-yl)piperidine-3-carboxamide;

N-(1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino) pyrimidin-2-yl)azetidin-3-yl)acetamide;

1-(5-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino) pyrimidin-2-yl)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)ethanone;

1-isopropyl-N-(2-(5-(methylsulfonyl)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl) pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

4-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino) pyrimidin-2-yl)piperazine-1-carboxamide;

1-isopropyl-N-(2-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(3-methoxypiperidin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-(1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)piperidin-4-yl)urea;

1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-4-methylpiperidine-4-carboxamide;

N-(1-(4-(1-isopropyl-1H-imidazo[4, 5-c]pyridin-6-ylamino)pyrimidin-2-yl)azetidin-3-yl)methanesulfonamide;

1-(1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)azetidin-3-yl)urea;

1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)pyrrolidine-3-carboxamide;

N-(1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)piperidin-4-yl)methanesulfonamide;

N-(2-(3-aminoazetidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-N,N-dimethylpyrrolidine-3-carboxamide;

1-isopropyl-N-(2-(4-(oxetan-3-yl)piperazin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(3-methoxypropyl)pyrimidine-2,4-diamine;

4-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1-methylpiperazine-2-carboxamide;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-2,5′-bipyrimidine-2′,4-diamine;

3-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino)-2,2-dimethylpropanamide;

3-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yloxy)propan-1-ol;

7-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one;

2-(1-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)piperidin-4-yloxy)acetamide;

3-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino)propanamide;

3-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yloxy)-2,2-dimethylpropan-1-ol;

1-isopropyl-2-methyl-N-(2-(1-(methylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-2-methyl-N-(2-(3-(methylsulfonyl)phenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(1-((2-methoxyethyl)sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)-[2,5′-bipyrimidin]-2′-ol;

2-(4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)ethanol;

N-(2-(1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(1-isopropyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2′-methoxy-[2,5′-bipyrimidin]-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(4-ethoxypiperidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-oxa-7-azaspiro[4.4]nonan-7-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine; or

N-(2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine.

18. The compound according to claim 1 , wherein said compound is:

1-isopropyl-N-(2-(3-(methylsulfonyl)pyrrolidin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

3-((4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)tetrahydro-2H-thiopyran 1,1-dioxide;

N-(2-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

3-((4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)cyclobutanol;

3-((4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)tetrahydrothiophene 1,1-dioxide;

2-(difluoromethyl)-1-isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(7,7-dimethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

2-((4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)-N-methyl ethanesulfonamide;

3-((4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)-2,2-dimethylpropanamide;

1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(1-methylpiperidin-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid;

1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)(morpholino)methanone;

(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)(pyrrolidin-1-yl)methanone;

N,1-diisopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-(2-hydroxyethyl)-1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(4-ethylpiperazin-1-yl)(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)methanone;

6-((2-(4-ethoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(4-isopropoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(4-cyclopropoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-((1,1-dioxidotetrahydrothiophen-3-yl)amino)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

2-{[4-(1-Isopropyl-1H-pyrrolo[3,2-c]pyridin-6-ylamino)pyrimidin-2-yl]methylamino}ethanol;

2-{Methyl-[4-(1-phenyl-1H-pyrrolo[3,2-c]pyridin-6-ylamino)pyrimidin-2-yl]amino}ethanol;

(1-Isopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine formate salt;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-(2-piperidin-1-yl-pyrimidin-4-yl)amine;

1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidine-4-carboxylic acid amide;

4-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperazin-2-one;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-pyrazol-1-ylpiperidin-1-yl)pyrimidin-4-yl]amine;

[2-(4-Imidazol-1-yl-piperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-[1,2,4]triazol-1-ylpiperidin-1-yl)pyrimidin-4-yl]amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-(2-[1,2]oxazinan-2-ylpyrimidin-4-yl)amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-(2-thiomorpholin-4-ylpyrimidin-4-yl)amine;

{1-[4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-ylmethyl}dimethylammonium formate;

2-{1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-yl}ethanol;

2-{[4-(1-Cyclopentyl-1H-pyrrolo[3,2-c]pyridin-6-ylamino)pyrimidin-2-yl]methylamino}ethanol formate salt;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(1-oxa-8-azaspiro[4.5]dec-8-yl)pyrimidin-4-yl]amine formate salt;

1-{4-[4-(l-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperazin-1-yl}ethanone formate salt;

2-{1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)-pyrimidin-2-yl]-piperidin-4-yl}-propan-2-ol;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxy-4-methylpiperidin-1-yl)pyrimidin-4-yl]amine;

1-[4(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]azetidine-3-carbonitrile;

1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]azetidin-3-ol;

N4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(R)-tetrahydrofuran-3-ylpyrimidine-2,4-diamine;

1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidine-4-carbonitrile;

[2-(4-Methoxypiperidin-1-yl)-pyrimidin-4-yl]-[1-(2,2,2-trifluoroethyl)-1H-imidazo[4,5-c]pyridin-6-yl]amine formate salt;

(1-Cyclopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine formate salt;

(1-Cyclobutyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine formate salt;

(1-Cyclohexyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

±(1-sec-butyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine; or

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(1,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)pyrimidin-4-yl]amine.

19. The compound according to claim 1 , wherein said compound is:

{2-[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)piperidin-1-yl]pyrimidin-4-yl}-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine formate salt;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-{2-[4-(2-methoxyethoxy)piperidin-1-yl]pyrimidin-4-yl}amine;

[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl]-[1-(2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-yl]amine formate salt;

2-{1-[4-(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-yl}isobutyramide;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(3-methyl-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl)pyrimidin-4-yl]amine;

[2-(3,6-Dihydro-2H-pyridin-1-yl)-pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{2-[4-(2-Dimethylaminoethoxy)piperidin-1-yl]pyrimidin-4-yl}-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{2-[4-(2-Dimethylaminoethyl)-piperidin-1-yl]pyrimidin-4-yl}-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(1-tert-butyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

[1-(2-Methoxy-1,1-dimethylethyl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(1-methanesulfonylpiperidin-4-yl)pyrimidin-4-yl]amine;

1-((4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)-2-methylpropan-2-ol;

N2-(cyclopropylmethyl)-N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-3-ol;

4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)morpholine-2-carboxamide;

N-(2-(hexahydro-1H-pyrido[1,2-a]pyrazin-2(6H)-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1,4-diazepan-2-one;

2-(4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperazin-1-yl)ethanol;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-methyl-N2-((tetrahydrofuran-2-yl) m ethyl)pyrimidine-2,4-diamine;

1-isopropyl-N-(2-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

3-((4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)cyclohexanol;

N-(2-(2-azabicyclo[2.1.1]hexan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-((1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-yl)methyl)pyrrolidin-2-one;

1-(4-((4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)ethanone;

4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N,2-dimethylmorpholine-2-carboxamide;

tert-butyl 4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-2-methylpiperazine-1-carboxylate;

tert-butyl 4-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperazine-1-carboxylate;

1-isopropyl-N-(2-(7-methoxy-2-azabicyclo[2.2.1]heptan-2-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N-methylpyrrolidine-3-carboxamide;

1-(4-4-((1-isopropyl-1H-imidazo[4, 5-c]pyridine-6-yl)amino)pyrimidin-2-yl)-1,4-diazepan-1-yl)ethanone;

N-(2-3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridine-6-amine;

3-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridine-6-yl)amino)pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide;

(1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-yl)methanol;

N-(2-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(4-cyclopropylpiperazin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(3,4-difluoropyrrolidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(5-fluoro-2-azabicyclo[2.2.1]heptan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

7-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-2,7-diazaspiro[4.4]nonan-1-one;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(2-methoxy-2-methylpropyl)pyrimidine-2,4-diamine;

N-(2-(hexahydrofuro[3,2-c]pyridin-5(6H)-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(hexahydrofuro[3,4-c]pyridin-5(3H)-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

3-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N-methyl-3-azabicyclo[3.1.0]hexane-6-carboxamide;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N-methylazetidine-3-carboxamide;

(1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)azetidin-3-yl)(morpholino)methanone;

2-(1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-yl)-N,N-dimethylacetamide;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)azepan-4-ol;

tert-butyl (1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)pyrrolidin-3-yl)(methyl)carbamate;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N,4-dimethylpiperidine-4-carboxamide;

(1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)pyrrolidin-2-yl)methanol;

N2-((1-ethylpyrrolidin-3-yl)methyl)-N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-methylpyrimidine-2,4-diamine; or

N-(2-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine.

20. The compound according to claim 1 , wherein said compound is:

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-((tetrahydro-2H-pyran-3-yl)methyl)pyrimidine-2,4-diamine;

N-(2-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-((tetrahydro-2H-pyran-4-yl)methyl)pyrimidine-2,4-diamine;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-4-methylpyrrolidin-3-ol;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(2-(4-methylpiperidin-1-yl)ethyl)pyrimidine-2,4-diamine;

N-(2-(2,6-dioxa-9-azaspiro[4.5]decan-9-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(tetrahydro-2H-furo[2,3-c]pyrrol-5(3H)-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(6-oxa-2-azaspiro [3.5]nonan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4, 5-c]pyridin-6-amine;

7-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-7-azabicyclo[2.2.1]heptane-2-carboxamide;

1-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-methylpyrrolidin-3-ol;

N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2-azabicyclo[3.1.0]hexan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(3-(aminomethyl)pyrrolidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(4-(aminomethyl)piperidin-1-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N2-ethyl-N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

N-(2-(2,7-diazaspiro[3.5]nonan-7-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2,6-diazaspiro[3.5]nonan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2,8-diazaspiro[4.5]decan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1,8-diazaspiro[4.6]undecan-8-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2,6-diazaspiro[4.5]decan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(3,9-diazaspiro[5.5]undecan-3-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1,7-diazaspiro[3.5]nonan-7-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(1-oxa-8-azaspiro[4.5]decan-3-yl)pyrimidine-2,4-diamine;

N-(2-(1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-oxa-4,8-diazaspiro[5.5]undecan-8-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2-amino-7-azaspiro[3.5]nonan-7-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N2-(6-azaspiro[2.5]octan-1-ylmethyl)-N4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

N-(2-(1-amino-3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

N4(2-(1-(aminomethyl)-2-azabicyclo[2.1.1]hexan-2-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

(1R,5S,6r)-3-(4-((1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide;

N-(2-(2-aminopyridin-4-yl)pyrimidin-4-yl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(3-(methoxymethyl)piperazin-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

3-(4-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yloxy)-2,2-dimethylpropanamide;

N-(3-hydroxypropyl)-1-isopropyl-6-2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(3-morpholinopropyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(2-(4-methylpiperazin-1-yl)ethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(2-(piperazin-1-yl)ethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(piperidin-4-ylmethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(2-(methylsulfonyl)ethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-(azetidin-3-yl)-1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(6-(2-(3-Amino-1-(cyclopropylmethyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

N-(4-Cyanocyclohexyl)-6-((2-(1-(cyclopropyl sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

2-(3-(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-4-methyl-1H-pyrazol-1-yl)ethanol; or

N-(2-(1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-3-(2H-1,2,3-triazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine.

21. The compound according to claim 1 , wherein said compound is:

2-(4-(6-(2-(1-(Ethylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)-N-(oxetan-3-yl)acetamide;

4-(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)pyrrolidin-2-one;

N-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-2-methyl-1-(1,1,1-trifluoropropan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(1-(pyrrolidin-3-ylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-(3-(4-(4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1H-pyrazol-1-ylsulfonyl)pyrrolidin-1-yl)ethanone;

1-Isopropyl-2-methyl-N-(2-(1-(oxetan-3-ylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

(1-Isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)(4-m ethylpiperazin-1-yl)methanone;

2-Chloro-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-2-(difluoromethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-amine;

6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-imidazo[4,5-c]pyridine-2-carbaldehyde;

(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(pentan-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(trans)-N-{1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methoxypiperidin-3-yl}methanesulfonamide formate salt;

(trans)-[2-(3-Amino-4-methoxypiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[1-(1-Cyclopropylethyl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

(2-Cyclohexylpyrimidin-4-yl)-(1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{2-[4-(2-Aminoethyl)-4-methoxypiperidin-1-yl]pyrimidin-4-yl}(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-(4-Aminomethyl-4-methoxypiperidin-1-yl)pyrimidin-4-yl](1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

(1-Isopropyl-6-((2-((1R,5R,8r)-8-methoxy-3-azabicyclo[3.2.1]octan-3-yl)pyrimidin-4-yl)amino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

{6-[2-(4-Aminomethyl-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

(2-Cyclohex-1-enylpyrimidin-4-yl)-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidine-2-carbonitrile;

2-1{6-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-1-yl}ethanol;

2-{6-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-2-yl}ethanol;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-(1-isopropyl-2-methoxymethyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-(3,3-dimethyl-2,3-dihydro-1-oxa-3a,6,8-triazacyclopenta[a]inden-5-yl)-amine;

(R)-1-{1-((R)-sec-Butyl)-6-[2-(1-ethanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol;

2-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yloxy}ethanol;

N 6 -[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-1-isopropyl-N 2 ,N 2 -dim ethyl-1H-imidazo[4,5-c]pyridine-2,6-diamine;

[2-(Azetidin-3-yloxy)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(1-cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-yl]amine;

[2-(Azetidin-3-yloxy)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(1H-pyrazol-4-yl)pyrimidin-4-yl]amine;

[(R)-6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-(2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]methanol;

(1-Isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(1-methanesulfonylpiperidin-4-yl)pyrimidin-4-yl]amine;

(R)-1-[6-[2-((3R,4S)-3-Fluor o-4-methoxypiperidin-1-yl)-pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

(3R,4S)-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}-piperidin-4-ol;

(R)-1-[6-[2-((3S,4R)-3-Fluoro-4-methoxypiperidin-1-yl)-pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

(3S,4R)-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methyl ethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}-piperidin-4-ol;

1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidine-3-carbonitrile;

N 6 -[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-yl]-1-isopropyl-N 2 -methyl-1H-imidazo[4,5-c]pyridine-2,6-diamine;

(±)-1-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}ethanol;

[2-(2-Ethylaminothiazol-5-yl)pyrimidin-4-yl](1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

cis-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(R)-1-[6-[2-(cis-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-((R)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]propionamide;

2-{[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]methyl}-2-methylbutyric acid;

2-{[4(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]methyl}-2-methylbutyramide;

2-Hydroxy-3-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]propionamide;

3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2,2-dimethylpropionic acid; or

2-Hydroxymethyl-3-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2-methylpropionamide.

22. The compound according to claim 1 , wherein said compound is:

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(3-methoxy-3-methylbut-1-ynyl)pyrimidin-4-yl]amine;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(3-methoxy-3-methylbutyl)pyrimidin-4-yl]amine;

1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-3-methylpyrrolidine-3-carboxylic acid amide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[((E)-2-pent-1-enyl)pyrimidin-4-yl]amine;

(E)-4-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-2-methylbut-3-en-2-ol;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-(2-pyridin-3-ylpyrimidin-4-yl)amine;

(E)-4-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-2,2-dimethylbut-3-enoic acid amide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(3-methyl-3H-imidazol-4-yl)pyrimidin-4-yl]amine;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(2-methylaminothiazol-5-yl)pyrimidin-4-yl]amine;

5-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyridine-2-carboxylic acid amide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[12-(6-methylaminopyridin-3-yl)pyrimidin-4-yl]amine;

N-{5-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]thiazol-2-yl}-N-methylacetamide;

[2-(2-Benzenesulfonyl-3-methyl-3H-imidazol-4-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-(2-Dimethylaminothiazol-5-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

1-[4(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]imidazolidin-one;

N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine;

N-(2-4-Methoxypiperidin-1-yl)pyrimidin-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine;

(+)-1-(sec-Butyl)-6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(−)-1-(sec-butyl)-6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3S,4R)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3 S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide

N-(6-((2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)acetamide;

N-(6-((2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-2-hydroxyacetamide;

N 4 -(Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N 2 -(2-methyl-2-(4H-1,2,4-triazol-3-yl)propyl)pyrimidine-2,4-diamine;

N-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-3-morpholino-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(4-(6-((2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)acetamide;

(+/−)-1-(1-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-imidazol-4-yl)ethanol;

1-Isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-3-(methylsulfonyl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

(6-((2-(1-(1-Fluorovinyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

6-((2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-2-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-(2-(5-Chloro-1-(cyclopropylmethyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(4-(methyl sulfonyl)-1H-imidazol-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(4-(methylsulfinyl)-1H-imidazol-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-((R)-sec-butyl)-6-((2-((3R,4S)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-((S)-sec-butyl)-6-((2-((3R,4S)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(4-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-&-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol;

2-(4-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-1-ol;

3-((4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)thio)-2,2-dimethylpropanamide;

1-Isopropyl-2-methyl-N-(2-(1-(pyrrolidin-3-ylmethyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-3-(3, 5-dimethyl-1H-pyrazol-4-yl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-3-(4-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

1-(4-((1-Isopropyl-3-(4-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3,3-dimethylpiperidin-4-ol;

2-(3-(6-((2-((3R,4S)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-4-methyl-1H-pyrazol-1-yl)ethanol;

3-(6-((2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)butanenitrile;

(cis)-3-(6 ((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentanecarbonitrile;

(trans)-3-(6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentanecarbonitrile;

3-(6-((2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)butanamide; or

4-(1-(6-((2-(4Methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)ethyl)benzonitrile.

23. The compound according to claim 1 , wherein said compound is:

4-(1-(6-((2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)ethyl)benzamide;

1-(1H-Indazol-4-ylmethyl)-N-[2-(4-methoxy-1-piperidyl)pyrimidin-4-yl]-2-methyl-imidazo[4,5-c]pyridin-6-amine;

1-Benzyl-N-[2-(4-methoxy-1-piperidyl)pyrimidin-4-yl]-2-methyl-imidazo[4,5-c]pyridin-6-amine;

1-[(1S)-1-(1H-Benzimidazol-5-yl)ethyl]-N-[2-(4-methoxy-1-piperidyl)pyrimidin-4-yl]-2-methyl-imidazo[4,5-c]pyridin-6-amine;

1-((1H-Benzo[d]imidazol-4-yl)methyl)-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-((1H-Benzo[d]imidazol-5-yl)methyl)-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(3-methylisothiazol-5-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

(5-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)thiazol-2-yl)methanol;

N-(2-(3,5-Di methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(3-Amino-1-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(3-(1I-Pyrazol-5-yl)piperadine-1-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(1-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-N-(2-isoxazol-4-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2H-1,2,3-triazol-2-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridine-6-amine;

1-Isopropyl-2-methyl-N-(2-(3-methyl-1H-1,2,4-triazol-5-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridine-6-amine;

[2-((3RS,4SR)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(R)-1-[6-[2-(2-Methanesulfonyl-2-methylpropoxy)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

2,2-Difluoro-3-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]propionamide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methyl-2-methylaminothiazol-5-yl)pyrimidin-4-yl]amine;

{Isopropyl-6-[2-(4-methyl-2-methylaminothiazol-5-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

{1-Isopropyl-6-[2-(3-methyl-2-methylamino-3H-imidazol-4-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

[2-(2-Aminothiazol-5-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{6-[2-(2-Aminothiazol-5-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

[2-(±z)-(trans-3-Fluoro-4-methanesulfonylpiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-(±)-(cis-3-Fluoro-4-methylsulfanylpiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-(±)-(cis-3-Fluoro-4-methanesulfinylpiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(3RS,4SR)-3-Fluoro-1-[4-(2-hydroxymethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methylpiperidin-4-ol;

(3R*,4S*)-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}-4-methylpiperidin-4-ol;

(±)-(6-[2-(cis-3-Fluoro-4-methylsulfanylpiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

{6-[2-(cis-3-Fluoro-4-methanesulfinylpiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

4-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)cyclohex-3-enol;

N-(2-(3-Chloro-1-(cyclopropylmethyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

(±)-(cis)-1-(4-(2-(Hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-3-(trifluoromethyl)piperidin-4-ol;

(−)-(trans)-1-(4-(2-(Hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-3-(trifluoromethyl)piperidin-4-ol;

(1-Isopropyl-6-(2-((±)-(cis)-4-methoxy-3-(trifluoromethyl)piperidin-1-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-Isopropyl-6-(2-((±)-(trans)-4-methoxy-3-(trifluoromethyl)piperidin-1-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(±)-(trans)-1-(4-(2-(Hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-3-methylpiperidin-4-ol;

(±)-(cis)-1-(4-(2-(Hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-3-methylpiperidin-4-ol;

(1-Isopropyl-6-(2-((±)-(cis)-4-methoxy-3-methylpiperidin-1-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(3RS,4RS)-4-cyclopropyl-3-fluoro-1-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-ol;

(6-(2-(cis)-3-Chloro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-(tetrahydro-2H-pyran-4-yl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(4-Hydroxy-4-methylpiperidin-1-yl)pyrimidin-4-ylamino)-N-(tetrahydro-2H-pyran-4-yl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3S,4R)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-((3SR,4SR)-3-fluorotetrahydro-2 I-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-(4-hydroxy-4-methylpiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-((3S,4R)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(1-(sec-butyl)-6-((2-((3S,4R)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)pyrrolidin-2-one;

1-(1-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-imidazol-4-yl)ethanol; or

(±)-(cis)-1-(4-(1-((S)-3,3-Difluorobutan-2-yl)-2-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-3-fluoropiperidin-4-ol.

24. The compound according to claim 1 , wherein said compound is:

(3RS,4SR)-3-Fluoro-1-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-methylpiperidin-4-ol;

1-sec-Butyl-6-(2-((±)-cis-5-fluoro-4-hydroxy-3,3-dimethylpiperidin-1-yl)pyrimidin-4-ylamino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-N-ethyl-6-((2-((3S,4R)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-N-ethyl-6-((2-((3 S,4R)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(±)-1-(sec-butyl)-6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(±)-6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-((cis)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-(4-hydroxy-3,3-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydrofuran-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-(4-hydroxy-3,3-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3 S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(1-(N,N-dimethylsulfamoyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-ethyl-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(1-(N,N-dimethylsulfamoyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(oxetan-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(oxetan-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-((3 S,4R)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-((3R,4S)-3-fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-(tetrahydrofuran-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-(4-hydroxy-3,3-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(±)-6-((2-(4-hydroxy-3,3-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(oxetan-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-N-methylacetamide;

1-isopropyl-N-(oxetan-3-yl)-6-((2-(1-(pyrrolidin-1-ylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-(sec-butyl)-6-((2-((3R,4S)-3-fluoro-4-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-N-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

N-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-2-hydroxy-N-methylacetamide;

N-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-2-hydroxy-2-methylpropanamide;

N-(2-(1-(ethylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-3-(1-(2-(methylsulfonyl)ethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)ethanol;

1-isopropyl-2-methyl-N-(2-(1-((1-methyl-1H-pyrazol-3-yl)sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

4-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethyl-1H-pyrazole-1-sulfonamide;

(±)-1-isopropyl-2-methyl-N-(2-(1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-2-methyl-N-(2-(3-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-(cyclopropylsulfonyl)-3-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-3-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)ethanol;

3-(1H-imidazol-4-yl)-1-isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-1H-pyrrolo([3,2-c]pyridin-6-amine;

(±)-N-(2-(1-(((1,4-dioxan-2-yl)methyl)sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-((2-ethoxyethyl)sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

(±)-1-isopropyl-2-methyl-N-(2-(1-((tetrahydrofuran-3-yl)sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-((1-ethyl-1H-pyrazol-4-yl)sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

(6-((2-(1-(difluoromethyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

1-isopropyl-N-(2-(1-(isopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

2-(4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)acetamide;

2-(3-(1-isopropyl-6-((24(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)acetamide;

1-isopropyl-N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-3-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(4-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)acetamide;

1-isopropyl-2-methyl-N-(2-(1-(1-(2,2,2-trifluoroethyl)azetidin-3-yl)-1H-pyrazol-4-yl)pyrimidin- 4 -yl)-1H-imidazo[4,5-c]pyridin-6-amine; or

N4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(1-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine.

25. The compound according to claim 1 , wherein said compound is:

N-(2-(1-(azetidin-3-yl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

(+)-3-((4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)amino)-2,2-dimethylbutanamide;

1-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-4-methylpiperidin-4-ol;

(±)-N-(2-(3-ethylmorpholino)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N2-(2-(1H-pyrazol-4-yl)ethyl)-N4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

N-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)-1-(2-(methylsulfonyl)ethyl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

1-isopropyl-2-methyl-N-(2-(4-(methylthio)-1H-imidazol-1-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

2-(1-(4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-imidazol-4-yl)propan-2-ol;

2-(4-(4-((1-isopropyl-2-methyl-1I H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)-2-methylpropanamide;

2-(4-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)propanenitrile;

2-(4-(4-((1-isopropyl-2-methyl-1I H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)-N,2-dimethylpropanamide;

1-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3,3-dimethylpiperidin-4-ol;

N-(2-(4-amino-3,3-di methylpiperidin-1-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-(azetidin-3-ylmethyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-(3-aminopropyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-2-methyl-N-(2-(1-((3-methyloxetan-3-yl)methyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

3-(4-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1H-pyrazol-1-yl)tetrahydrothiophene 1,1-dioxide;

(1R,5S,8r)-3-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-azabicyclo[3.2.1]octan-8-ol;

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-yl)pyrimidin-yl)-3-(1,4-dimethyl-1H-pyrazol-5-yl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(3-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-5-methyl-1H-pyrazol-1-yl)ethanol;

2-(5-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-3-methyl-1H-pyrazol-1-yl)ethanol;

2-(4-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-3-methyl-1H-pyrazol-1-yl)ethanol;

2-(4-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-5-methyl-1H-pyrazol-1-yl)ethanol;

2-(4-(6-(2-(1-(cyclopropyl sulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)propane-1,3-diol;

3-((4-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)methyl)oxetan-3-ol;

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-3-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine;

2-(4-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)-1-(4-methylpiperazin-1-yl)ethanone;

2-(4-(6-(2-(1-(ethylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)-N-(tetrahydro-2H-pyran-4-yl)acetamide;

2-(4-(6-(2-(4-(hydroxymethyl)-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanamide;

2-(4-(6-(2-(4-(hydroxymethyl)-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)acetamide;

N-ethyl-2-(4-(6-(2-(1-(ethylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1H-pyrazol-1-yl)acetamide;

6-(2-(1-(ethylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-N-(oxetan-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-isopropyl-6-(2-(4-methoxypiperidin-1-yl)pyrimidin-4-ylamino)-N-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-((1s,3S,4R)-3,4-dihydroxycyclopentyl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-((1r,3R,4S)-3,4-dihydroxycyclopentyl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-N-(2-(methylsulfonyl)ethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-N-(tetrahydrofuran-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-(4-hydroxycyclohexyl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-isopropyl-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-N-(tetrahydro-2H-thiopyran-4-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-N-(tetrahydro-2H-pyran-3-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

4-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)-1-(2-hydroxyethyl)pyrrolidin-2-one;

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

3-(4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino)-N,N,2,2-tetramethylpropanamide;

3-(4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino)-N,2,2-trimethylpropanamide;

(24(4-(4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1H-pyrazol-1-ylsulfonyl)cyclopropyl)methanol; or

4-(4-(4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1H-pyrazol-1-ylsulfonyl)pyrrolidin-2-one.

26. The compound according to claim 1 , wherein said compound is:

1-(3-(4-(4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1H-pyrazol-1-ylsulfonyl)azetidin-1-yl)ethanone;

N-(2-(1-(azetidin-3-ylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-2-methyl-N-(2-(1-(1-methylazetidin-3-ylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

2-(difluoromethyl)-1-isopropyl-N-(2-(1-(isopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

3-(4-(4-(2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1H-pyrazol-1-yl)-2,2-dimethylpropan-1-ol;

3-(44(4-(2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl)-1H-pyrazol-1-yl)-2,2-dimethylpropanamide;

3-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin--ylamino)-2-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylbutan-1-ol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(1R,2R)-2-methylcyclopentyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-((1R,2R)-2-methylcyclopentyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-phenyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

4-(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-2-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl)-1-methylpyrrolidin-2-one;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(1-methyl cyclopentyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(4-methylpentan-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-cyclohexyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(3,3-difluoroCyclobutyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-cyclopentyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-(3,3-difluorocyclopentyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(3,3,3-trifluoropropyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(1-methylcyclobutyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-tert-butyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-phenethyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(3-methylbutan-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-(1-cyclopropylpropan-2-yl)-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

2-{6-[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-ylamino]-2-methyl-imidazo[4,5-c]pyridin-1-yl}propan-1-ol;

[1-((S)-2-Methoxy-1-methylethyl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

[1-(3-Methoxy-1-methylpropyl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]amine;

3-{6-[2-(4-Methoxypiperidin-1-yl)pyrimidin-4-ylamino]-2-methylimidazo[4,5-c]pyridin-1-yl}butan-1-ol;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-((1 RS,3RS,5SR)-3-methoxy-8-azabicyclo[3.2.1]oct-8-yl)pyrimidin-4-yl]amine;

N-2-(4-Methoxypiperidin-1-yl)pyrimidin-4-yl)-2-methyl-1-phenyl-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(1-Oxa-7-azaspiro[3.5]nonan-7-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

3-(1-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-4-methoxypiperidin-4-yl)propan-1-ol;

(±)-(cis)-5-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)hexahydrooxazolo[4,5-c]pyridin-2(3H)-one;

N4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(2-methyl-2-(methylsulfonyl)propyl)pyrimidine-2,4-diamine;

N-(2-(3,6-Dihydro-2H-pyran-4-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-Isopropyl-2-methyl-N-(2-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

8-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-2,8-diazaspiro[4.5]decan-1-one;

1-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-ol;

1-(4-((2-(Hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-ol;

(±)-3-Fluoro-1-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-ol;

N-(2-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

(±)-3,3-Difluoro-11-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-ol;

(±)-1-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-4-methoxypiperidin-3-ol;

(±)-1-(4-((1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-methoxypiperidin-4-ol;

(±)-3-Fluoro-1-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)piperidin-4-ol;

(±)-1-Isopropyl-N-(2-(4-methoxy-2-methylpiperidin-1-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

(1-Isopropyl-6-((2-(4-(trifluoromethyl)piperidin-1-yl)pyrimidin-4-yl)amino)-1H-imidazo[4,5-c]pyrimidin-2-yl)methanol;

(6-((2-(4-Ethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)[2-(2-methyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)-pyrimidin-4-yl]amine; or

[2-(4-Dimethylaminomethyl-4-methoxypiperidin-1-yl)pyrimidin-4-yl](1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine.

27. The compound according to claim 1 , wherein said compound is:

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)[2-(4-methoxy-4-methoxymethylpiperidin-1-yl)pyrimidin-4-yl]amine;

{1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methoxypiperidin-4-yl}methanol;

N2-(3-Amino-2,2-dimethylpropyl)-N4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2,2-dimethylpropan-1-ol;

2-(1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methoxypiperidin-4-yl) ethanol;

{2-[4-(2-Dimethylaminoethyl)-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

N4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(3-methoxy-2,2-dimethylpropyl)pyrimidine-2,4-diamine;

3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2,2-dimethylpropionitrile; formate salt;

(±)-[2-((cis)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl](1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine; formate salt;

(±)-[2-((trans)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(±)-{6-[2-((cis)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol; formate salt;

(±)-{6-[2-((trans)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol; formate salt;

(±)-[2-(3,3-Difluoro-4-methoxypiperidin-1-yl)pyrimidin-4-yl](1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine; formate salt;

(±)-{6-[2-(3,3-Difluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol; formate salt;

(±)-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)[2-(2-trifluoromethyl-piperidin-1-yl)pyrimidin-4-yl]amine;

(±)-{1-Isopropyl-6-[2-(2-trifluoromethylpiperidin-1-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}methanol; formate salt;

N-(2-(4-methoxypiperidin-11-yl)pyrimidin-4-yl)-3,3-dimethyl-2,3-dihydrooxazolo[3′,2′: 1,2]imidazo[4,5-c]pyridin-6-amine;

(1-(4-((3,3-dimethyl-2,3-dihydrooxazolo[3′,2′: 1,2]imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-4-methoxypiperidin-4-yl)methanol;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-(4,4-dimethyl-3,4-dihydro-2H-1-oxa-4a,7,9-triazafluoren-6-yl)amine;

(R)-1-{(S)-1-sec-Butyl-6-[2-(1-ethanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}-ethanol;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-[1-isopropyl-2-(2-methoxy-ethoxy)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

N6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-1-isopropyl-N2-(2-methoxyethyl)-1H-imidazo[4,5-c]pyridine-2,6-di amine;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-(4,4-dimethyl-3,4-dihydro-1H-2-oxa-4a,7,9-triazafluoren-6-yl)amine;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-[2-methyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

(R)-1-[(R)-6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-(2,2,2-trifluoro-1-methyl-ethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

(R)-1-{(1-((R)-sec-Butyl)-6-[2-(1-cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}ethanol;

3-Fluoro-1-(4-[2-((R)-1-hydroxyethyl)-1-((R)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl)-piperidin-4-ol;

(R)-1-[6-[2-(3-Fluoro-4-methoxypiperidin-1-yl)-pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methyl-ethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

2-{4-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperaziN-1-yl}isobutyramide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methanesulfonylpiperidin-1-yl)pyrimidin-4-yl]amine;

(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-methylsulfanylpiperidin-1-yl)pyrimidin-4-yl]amine;

1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidine-4-sulfonic acid amide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(3-methanesulfonylazetidin-1-yl)pyrimidin-4-yl]amine;

[2-(4-Difluoromethoxypiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(3aR,5R,6aS)-2-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]octahydro-cyclopenta[c]pyrrol-5-ol;

1-Isopropyl-N-(2-((3aR,5r,6aS)-5-methoxyhexahydrocyclopenta[c]pyrrol-2(1H)-yl)pyrimidin-4-yl)-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-{[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]methyl}cyclopropane carboxylic acid amide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-{2-[4-(propane-2-sulfonyl)piperidin-1-yl]pyrimidin-4-yl}amine;

(1-Isopropyl-6-{2-[4-(propane-2-sulfonyl)piperidin-1-yl]pyrimidin-4-ylamino}-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-1H-imidazole-4-sulfonic acid cyclopropylamide;

N2-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-N2-ethyl-1-isopropyl-1H-imidazo[4,5-c]pyridine-2,6-diamine;

2-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-ylmethoxy}ethanol;

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-[1-isopropyl-2-(2,2,2-trifluoroethyl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

{6-[2-(4-Hydroxymethyl-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

3-[4-(2-Hydroxymethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2,2-dimethylpropionic acid methyl ester;

(R)-1-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}ethanol;

(S)-1-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}ethanol;

2-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}propan-2-ol; or

[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-(2-cyclopropyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amine.

28. The compound according to claim 1 , wherein said compound is:

(±)-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-yl]-[1-isopropyl-2-(tetrahydrofuran-2-yl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

(4)-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-yl]-[1-isopropyl-2-(1-methoxyethyl)-1H-imidazo[4,5-c]pyridin-6-yl]amine;

[2-((S)-1-Aminoethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(1-cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-yl]amine;

[2-((R)-1-Aminoethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl]-[2-(1-cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-yl]amine;

(S)-i-{6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}ethane-1,2-diol;

(±)-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-yl]-(1-isopropyl-2-oxetaN-2-yl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methyl-ethyl)-1H-imidazo[4,5-c]pyridin-2-yl]methanol;

(R)-1-[6-[2-(1-Cyclopropanesulfonyl-1H-pyrazol-4-yl)-pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]-ethanol;

{6-[2-(3,6-Dihydro-2H-pyran-4-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

{1-Isopropyl-6-[2-(tetrahydropyran-4-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

[2-(2,5-Dihydrofuran-3-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(±)(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(tetrahydrofuran-3-yl)pyrimidin-4-yl]amine;

5-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyridine-2-carboxylic acid methylamide;

5-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyridine-2-carboxylic acid dimethylamide;

{6-[2-(2-Ethylaminothiazol-5-yl)-pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2-methylpropionamide;

3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2-methoxymethyl-2-methylpropionamide;

2-Hydroxy-3-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]-2-methylpropionamide;

4-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-ylamino]butyramide;

3-{[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]methylamino}-2,2-dimethylpropionamide;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-(2-pyridin-4-ylpyrimidin-4-yl)amine;

[2-(6-Aminopyridin-3-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyrindin-6-yl)amine;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(6-methanesulfonylpyridin-3-yl)pyrimidin-4-yl]amine;

{1-Isopropyl-6-[2-(2-methylaminothiazol-5-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl)}methanol;

N-{(E)-3-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-1,1-dimethylallyl}acetamide;

[2-(3-Fluoropiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-(4-Fluoropiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-((S)-3-Fluoropyrrolidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

[2-((R)-3-Fluoropyrrolidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{6-[2-(2-Dimethylaminothiazol-5-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

[2-(2-Ethylthiazol-5-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-yl)methylcarbamic acid tert-butyl ester,

1-(1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-yl}pyrrolidin-2-one;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(4-oxetan-3-ylpiperidin-1-yl)pyrimidin-4-yl]amine;

(2-Imidazol-1-ylpyrimidin-4-yl)-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(cis)-1-(4-((1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-2-methylpiperidin-4-ol;

N-(2-(3-amino-1H-pyrazol-1-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

N4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-N2-(1H-pyrazol-3-yl)pyrimidine-2,4-di amine;

(1-isopropyl-2-methyl-N-(2-(3-methylmorpholino)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

N-(2-(2,4-dimethyl-1H-imidazol-1-yl)pyrimidin-4-yl)-1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-amine;

1-isopropyl-2-methyl-N-(2-(4-(methylsulfonyl)phenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine;

[2-(1,5-Dioxa-9-azaspiro[5.5]undec-9-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(±)-cis-5-Fluoro-1-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-3,3-dimethylpiperidin-4-ol; formate salt;

(±)-cis-5-Fluoro-1-[4-(2-hydroxymethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-3,3-dimethylpiperidin-4-ol;

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)[2-(1,4,5,7-tetrahydropyrazolo[3,4-c]pyridin-6-yl)pyridin-4-yl]amine;

N2-(1,1-Dioxotetrahydrothiophen-3-ylmethyl)-N4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)pyrimidine-2,4-diamine;

[2-(6-Fluoro-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)pyrimidin-4-yl](1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

{6-[2-(6-Fluoro-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

{6-[2-((3*,4*)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol; or

(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-[2-(2-methanesulfonyl-2-methylpropoxy)pyrimidin-4-yl]amine.

29. The compound according to claim 1 , wherein said compound is:

[6-[2-((3 RS,4 SR)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]methanol;

(3RS,4SR)-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(R)-1-{6-[2-((3RS,4SR)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}ethanol;

{1-Isopropyl-6-[2-(2-methanesulfonyl-2-methylpropoxy)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

{1-Isopropyl-6-[2-(4-methanesulfonylpiperidin-1-yl)pyrimidin-4-ylamino]-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

(R)-1-[6-[2-(4-Methanesulfonylpiperidin-1-yl)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

(R)-1-[6-[2-(2-Methanesulfonyl-2-methyl-propylamino)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

1-Isopropyl-6-[2-(2-methanesulfonyl-2-methylpropylamino)pyrimidin-4-ylamino]-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid (tetrahydropyran-4-yl)amide;

(R)-1-[6-[2-(4-Hydroxymethyl-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

(3S,4R)-3-Fluoro-1-(4-[2-hydroxymethyl-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl) piperidin-4-ol;

(3R,4S)-3-Fluoro-1-{4-[2-hydroxymethyl-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(±)-2-({1-[4-(2-Hydroxymethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-2-yl}ethanol;

1-[4-(2-Hydroxymethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-trifluoromethylpiperidin-4-ol;

{6-[2-(2-Hydroxymethylpiperidin-1-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

{6-[2-(2-Ethylthiazol-5-yl)pyrimidin-4-ylamino]-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl}methanol;

(3RS,4SR)-3-Fluoro-1-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methylpiperidin-4-ol;

[((3RS,4SR)-3-Fluoro-4-methoxy-4-methylpiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(3RS,4RS)-3-Fluoro-1-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methylpiperidin-4-ol;

(3RS,4RS)-3-Fluoro-1-[4-(2-hydroxymethyl-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methylpiperidin-4-ol;

(3RS,4SR)-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}-4-methylpiperidin-4-ol;

[2-(4,4-Difluoropiperidin-1-yl)pyrimidin-4-yl]-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amine;

(R)-1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyrrolidine-3-carbonitrile;

(S)-1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyrrolidine-3-carbonitrile;

(R)-1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyrrolidin-3-ol;

(S)-1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]pyrolidin-3-ol;

1-[4-(1-Isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]-4-methylpiperidin-4-ol;

4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}-4-methylpiperidin-4-ol;

(S)-1-[6-[2-((cis)-3-Fluoro-4-methoxypiperidin-1-yl)pyrimidin-4-ylamino]-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-2-yl]ethanol;

(3S,4R)-3-Fluoro-1-{4-[2-((S)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(3R,4S)-3-Fluoro-1-{4-[2-((S)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(3 S,4R)-3-Fluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((R)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(3R,4S)-3-Fluoro-I 1-{4-[2-((R)-1-hydroxyethyl)-1-((R)-2,2,2-trifluoro-1-methyl ethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(3S,4R)-3-Fluoro-1-{4-[2-((S)-1-hydroxyethyl)-1-((R)-2,2,2-trifluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(3R,4S)-3-Fluoro-1-{4-[2-((S)-1-hydroxyethyl)-1-((R)-2,2,2-tri fluoro-1-methylethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(6-((2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-imidazo[4, 5-c]pyridin-2-yl)methanol;

(6-((2-(2-azabicyclo[2.1.1]hexan-2-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

9-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one;

4-(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-2-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl)pyrrolidin-2-one;

(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(4-methoxy-2-methylbutan-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(4,4,4-trifluorobutan-2-yl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(3-methylcyclopentyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(6-(2-(1-(Cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-1-(2-methylcyclopropyl)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

(1-Isopropyl-6-(2-((±)-(trans)-4-methoxy-3-methylpiperidin-1-yl)pyrimidin-4-ylamino)-1H-imidazo[4,5-c]pyridin-2-yl)methanol;

1-sec-Butyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-(1,4-dioxepan-6-yl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(3S,4S,5R)-3,5-Difluoro-1-{4-[2-((R)-1-hydroxyethyl)-1-((S)-2,2,2-trifluoro-1-methyl ethyl)-1H-imidazo[4,5-c]pyridin-6-ylamino]pyrimidin-2-yl}piperidin-4-ol;

(3SR,4SR)-3-fluoro-1-(4-((2-(hydroxymethyl)-1-isopropyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)pyrimidin-2-yl)-3-methylpiperidin-4-ol;

1-sec-Butyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-(2-hydroxyethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-sec-Butyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-(2,2,2-trifluoroethyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

1-sec-Butyl-6-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-ylamino)-N-(4-hydroxycyclohexyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxamide;

(±)-(3RS,5RS)-3,5-Difluoro-1-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-ol; or

(3R,4s,5S)-3,5-Difluoro-1-[4-(1-isopropyl-2-methyl-1H-imidazo[4,5-c]pyridin-6-ylamino)pyrimidin-2-yl]piperidin-4-ol.

Assignments (3)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2016

From: BRYAN, MARIAN C.; CHAN, BRYAN; HANAN, EMILY; HEFFRON, TIMOTHY; PURKEY, HANS

To: GENENTECH, INC.

Reel/Frame 039197/0732 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2015

From: ELLIOTT, RICHARD LEONARD; KNIGHT, JAMIE

To: ARGENTA DISCOVERY 2009 LIMITED

Reel/Frame 036391/0157 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2015

From: ARGENTA DISCOVERY 2009 LIMITED

To: GENENTECH, INC.

Reel/Frame 036391/0316 →

Continuity (5)

Continuation PCTUS2013070788 · Nov 19, 2013

Provisional Application 61728487 · Nov 20, 2012

Provisional Application 61784494 · Mar 14, 2013

Provisional Application 61866164 · Aug 15, 2013

Related Publication 20160016948A1 · Jan 21, 2016