Transdermal drug delivery method and system
View Patent ↗The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.
1. A method for transdermal administration of an active substance dissolved in a solvent, the method comprising:
placing a dispensing device in contact with skin, the dispensing device comprising a reservoir, a skin interface and a solvent recovery element;
dispensing a first portion of the active substance dissolved in the solvent from the reservoir to the skin interface;
delivering the active substance through the interface to the skin; and
removing solvent from the skin interface and trapping the solvent within the solvent recovery element to control delivery of the active substance through the interface to the skin.
2. The method of claim 1 , wherein the active substance and solvent are dispensed from the reservoir to the skin interlace in response to a control signal.
3. The method of claim 1 , further comprising adhesively attaching the skin interface to the skin.
4. The method of claim 1 , wherein the solvent is removed from the skin interface by the solvent recovery element while the skin interface is in contact with the skin.
5. The method of claim 1 , wherein the removing step comprises passing solvent through a separation layer between the skin interface and the solvent recovery element.
6. The method of claim 1 , wherein the removing step comprises evaporating solvent.
7. The method of claim 1 , further comprising controlling volume and frequency of active substance and solvent dispensed in the dispensing step.
8. The method of claim 1 , wherein the dispensing step comprises dispensing the active substance and solvent in a non-constant manner.
9. The method of claim 1 , wherein the dispensing step comprises dispensing the active substance and solvent according to a circadian rhythm of a user.
10. The method of claim 1 , further comprising ceasing removing solvent after ceasing dispensing to terminate delivery of the active substance through the interface to the skin.
11. The method or claim 1 , further comprising diffusing the active substance from the skin interface into the skin.
12. The method of claim 1 , wherein the removing step comprises moving solvent through a non-wettable but vapor permeable material.