Arteriovenous fistula maturation

1. A method comprising:

directing pressurized fluid using a controller comprising a source of pressurized fluid to inflate at least one inflatable bladder of a first compression garment secured to an outer portion of a limb of a subject and at least one inflatable bladder of a second compression garment secured to an outer portion of a limb of a subject

wherein the controller is in fluid communication with the first and second compression garments through tubing sets; and

based at least in part on the directed inflation of the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment, controlling forces applied to an arteriovenous fistula in the limb of the subject;

receiving at least one physiological parameter signal representative of one or more physiological parameters of the subject, wherein directing pressurized fluid is based at least in part on the at least one received physiological parameter signal to accomplish at least one of increasing the flow rate of blood through the arteriovenous fistula above a pulsatile flow rate and increasing the volume of blood in the arteriovenous fistula above a pulsatile volume of blood in the arteriovenous fistula to advance maturation of the fistula.

2. The method of claim 1 , wherein the at least one physiological parameter signal is indicative of natural pulsatile blood flow through the arteriovenous fistula.

3. The method of claim 2 , wherein directing pressurized fluid based at least in part on the physiological parameter signals indicative of natural pulsatile blood flow through the arteriovenous fistula includes inflating the at least one inflatable bladder to alter the physiological parameter signal from a natural pulsatile flow signal to a modified flow signal.

4. The method of claim 2 , wherein directing pressurized fluid to inflate the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment includes cyclically inflating and deflating the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment, with initiation each inflation and deflation cycle of the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment based at least in part on the signal indicative of the natural pulsatile blood flow through the arteriovenous fistula.

5. The method of claim 4 , wherein directing pressurized fluid to cyclically inflate and deflate the at least one inflatable bladder of the first compression garment and the least one inflatable bladder of the second compression garment based at least in part on the signal indicative of natural pulsatile blood flow through the arteriovenous fistula includes inflating the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment to alter the natural pulsatile blood flow signal to a modified flow signal.

6. The method of claim 2 , further comprising determining a waveform of blood flow through the arteriovenous fistula based at least in part upon the signal indicative of natural pulsatile blood flow through the arteriovenous fistula, wherein directing pressurized fluid to inflate the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment further includes inflating the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment based at least in part on the determined waveform.

7. The method of claim 2 , wherein the received signal indicative of natural pulsatile blood flow through the arteriovenous fistula is at least one of a measure of blood pulsation of the subject received from a pulse oximeter arranged at the at least one inflatable bladder of the first or second compression garment, a measure of electrical activity of the subject's heart received from an electrocardiogram connected to the subject, and a measure of pressure received from the pressure sensor in fluid communication with the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment.

8. The method of claim 1 , wherein the controlled forces applied to the arteriovenous fistula impart a therapeutic effect on the arteriovenous fistula.

9. The method of claim 8 , further comprising receiving a sensor signal indicative of thrombogenic material in the vicinity of the arteriovenous fistula, wherein controlling inflation of the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment includes inflating the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment based at least in part on the received sensor signal indicative of thrombogenic material.

10. The method of claim 9 , wherein the received sensor signal is an ultrasound sensor signal.

11. The method of claim 1 , wherein directing pressurized fluid to inflate the at least one inflatable bladder of the first compression garment and the at least one inflatable bladder of the second compression garment includes inflating a first inflatable bladder of the second compression garment disposed on the limb proximal to the arteriovenous fistula to compress an outer portion of the limb proximal to the arteriovenous fistula, and inflating a first inflatable bladder of the first compression garment disposed on the limb distal to the arteriovenous fistula to compress an outer portion of the limb distal to the arteriovenous fistula a period of time after the first inflatable bladder of the second compression garment is inflated.

12. The method of claim 11 , wherein inflating the first inflatable bladder of the first compression garment and first inflatable bladder of the second compression garment includes inflating the first inflatable bladder of the first compression garment after the first inflatable bladder of the second compression garment has been deflated.

13. The method of claim 1 , wherein the first compression garment is placed on the limb distal to the arteriovenous fistula.

14. The method of claim 13 , wherein the first compression garment is placed on a hand of the subject.

15. The method of claim 1 , wherein the second compression garment is placed on the limb proximal to the arteriovenous fistula.

16. The method of claim 15 , wherein the second compression garment is placed on an upper arm of the subject.