NEISSERIAL ANTIGENIC PEPTIDES
This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
1 . (canceled)
2 . A composition comprising an adjuvant and an isolated polypeptide including the amino acid sequence selected from SEQ ID NO: 11072 and SEQ ID NO: 24053.
3 . The composition of claim 2 , wherein the polypeptide does not comprise the full length protein sequence of SEQ ID NO: 41367, SEQ ID NO: 41369, or SEQ ID NO: 41371.
4 . The composition of claim 2 , wherein the amino acid sequence of SEQ ID NO: 11072 is an antigenic fragment of SEQ ID NO: 41369; or the amino acid sequence of SEQ ID NO: 24053 is an antigenic fragment of SEQ ID NO: 41371.
5 . The composition of claim 4 , wherein the polypeptide does not comprise the full length protein sequence of SEQ ID NO: 41367, SEQ ID NO: 41369, or SEQ ID NO: 41371.
6 . The composition of claim 2 , further comprising a pharmaceutically acceptable excipient or carrier.
7 . The composition of claim 6 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
8 . The composition of claim 3 , further comprising a pharmaceutically acceptable excipient or carrier.
9 . The composition of claim 8 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
10 . The composition of claim 4 , further comprising a pharmaceutically acceptable excipient or carrier.
11 . The composition of claim 10 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
12 . The composition of claim 5 , further comprising a pharmaceutically acceptable excipient or carrier.
13 . The composition of claim 12 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
14 . A method of inducing an immune response in a subject comprising administering to the subject an immunologically effective dose of the composition of claim 2 .
15 . The method of claim 14 , wherein the polypeptide does not comprise the full length protein sequence of SEQ ID NO: 41367, SEQ ID NO: 41369, or SEQ ID NO: 41371.
16 . The method of claim 14 , wherein the amino acid sequence of SEQ ID NO: 11072 is an antigenic fragment of SEQ ID NO: 41369; or the amino acid sequence of SEQ ID NO: 24053 is an antigenic fragment of SEQ ID NO: 41371.
17 . The method of claim 16 , wherein the polypeptide does not comprise the full length protein sequence of SEQ ID NO: 41367, SEQ ID NO: 41369, or SEQ ID NO: 41371.
18 . The method of claim 14 , wherein the composition further comprises a pharmaceutically acceptable excipient or carrier.
19 . The method of claim 18 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
20 . The method of claim 15 , wherein the composition further comprises a pharmaceutically acceptable excipient or carrier.
21 . The method of claim 20 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
22 . The method of claim 16 , wherein the composition further comprises a pharmaceutically acceptable excipient or carrier.
23 . The method of claim 22 , wherein the adjuvant comprises an aluminum phosphate adjuvant.
24 . The method of claim 17 , wherein the composition further comprises a pharmaceutically acceptable excipient or carrier.
25 . The method of claim 24 , wherein the adjuvant comprises an aluminum phosphate adjuvant.