IP Library › Patent Application 14752023
Patent Application
App. No. 14/752,023

SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS

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Quick Facts
Patent No.
US None
App. No.
14/752,023
Abstract

The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Claims (7)

1 . (canceled)

2 . A method of treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a DOT1L inhibitor.

3 . A method of treating hematological cancer comprising administering to a subject in need thereof a therapeutically effective amount of a DOT1L inhibitor.

4 . A method of treating leukemia comprising administering to a subject in need thereof a therapeutically effective amount of a DOT1L inhibitor.

5 . The method of claim 4 , wherein the leukemia is acute myeloid leukemia, acute lymphocytic leukemia or mixed lineage leukemia.

6 . The method of claim 4 , wherein the leukemia is a MLL-rearranged leukemia.

7 . The method of claim 4 , wherein the leukemia is a leukemia characterized by a partial tandem duplication of the MLL gene (MLL-PTD).

Assignments (2)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS AT REEL/FRAME: 051057/0848 Recorded Aug 13, 2022
From: BIOPHARMA CREDIT PLC
To: EPIZYME, INC.
Reel/Frame 061165/0501 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 17, 2015
From: OLHAVA, EDWARD J.; CHESWORTH, RICHARD; KUNTZ, KEVIN W.; RICHON, VICTORIA M.; POLLOCK, ROY M.; DAIGLE, SCOTT R.
To: EPIZYME, INC.
Reel/Frame 036125/0001 →