Compositions and methods for treating pancreatic cancer
The present disclosure provides compositions and methods for treating or reducing the risk of pancreatic cancer by administering compounds capable of inhibiting the expression or activity of RUNX3.
1. A method for reducing the risk of pancreatic cancer metastasis, comprising administering to a subject in need thereof an inhibitor of RUNX3 expression or activity.
2. The method of claim 1 , wherein the RUNX3 inhibitor comprises a nucleic acid selected from a double-stranded RNA or an antisense RNA.
3. The method of claim 1 , further comprising a second method of treatment selected from surgery, chemotherapy, radiation therapy, or any combination thereof.
4. The method according to claim 3 wherein the administration of the RUNX3 inhibitor is performed simultaneously, successively, or concomitantly with the second method of treatment.
5. The method of claim 2 , wherein the nucleic acid molecule comprises a sequence as set forth in SEQ ID NO.: 20.