Heterocyclic amide derivatives as P2X7 receptor antagonists

1. A compound of the formula (I),

wherein

n represents 1, 2 or 3;

m represents 0, 1 or 2;

p represents 0, 1 or 2;

X represents —O— or —CH 2 —;

R 1 represents hydrogen, (C 1 -C 2 )alkyl or hydroxy-(C 1 -C 2 )alkyl and R 2 represents hydrogen or halogen; or R 1 and R 2 together represent a —CH 2 CH 2 — or a —CH 2 CH 2 CH 2 — group;

each R 3 independently represents (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, hydroxy-(C 1 -C 3 )alkyl, hydroxy-(C 2 -C 3 )alkoxy, hydroxy-(C 2 -C 3 )alkoxy-(C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy-(C 1 -C 2 )alkyl, (C 1 -C 3 )fluoroalkyl, (C 1 -C 3 )fluoroalkoxy, cyano, halogen or phenoxy;

R 4 represents hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 3 )fluoroalkyl, amino, halogen or phenyl; and

R 5 represents hydrogen or methyl;

or a salt of such a compound.

2. The compound of formula (I) according to claim 1 , that is a compound of formula (Ixo),

wherein

n represents 1, 2 or 3;

m represents 0, 1 or 2;

p represents 1 or 2;

R 1 represents hydrogen, (C 1 -C 2 )alkyl or hydroxy-(C 1 -C 2 )alkyl and R 2 represents hydrogen or halogen; or R 1 and R 2 together represent a —CH 2 CH 2 — or a —CH 2 CH 2 CH 2 — group;

each R 3 independently represents (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, hydroxy-(C 1 -C 3 )alkyl, hydroxy-(C 2 -C 3 )alkoxy, hydroxy-(C 2 -C 3 )alkoxy-(C 1 -C 2 )alkyl, (C 1 -C 2 )alkoxy-(C 1 -C 2 )alkyl, (C 1 -C 3 )fluoroalkyl, (C 1 -C 3 )fluoroalkoxy, cyano, halogen or phenoxy; and

R 5 represents hydrogen or methyl;

or a salt of such a compound.

3. The compound of formula (I) according to claim 1 , wherein

m represents 0;

or a salt of such a compound.

4. The compound of formula (I) according to claim 1 , wherein

p represents 2;

or a salt of such a compound.

5. The compound of formula (I) according to claim 1 , wherein

R 1 represents hydrogen and R 2 represents chloro;

or a salt of such a compound.

6. The compound of formula (I) according to claim 1 , wherein

R 1 and R 2 together represent a —CH 2 CH 2 — group;

or a salt of such a compound.

7. The compound of formula (I) according to claim 1 , wherein

a first R 3 group is attached in para-position relative to the R 1 -bearing carbon atom and represents chloro; and

a second R 3 group is absent, or is attached in ortho-position relative to the R 1 -bearing carbon atom and represents methyl, cyclopropyl, methoxy, hydroxy-methyl, 2-hydroxy-ethoxy, (2-hydroxy-ethoxy)-methyl, methoxy-methyl, chloro or bromo;

or a salt of such a compound.

8. The compound of formula (I) according to claim 1 , wherein

R 4 represents hydrogen;

or a salt of such a compound.

9. The compound of formula (I) according to claim 1 , wherein

R 5 represents hydrogen;

or a salt of such a compound.

10. The compound of formula (I) according to claim 1 , selected from the group consisting of:

N-(4-chlorobenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichlorobenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2-chloro-4-fluorobenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(3,4-dichlorobenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2-bromo-4,6-dichlorobenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichlorophenethyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(3-(2,4-dichlorophenyl)propyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(1-(2,4-dichlorophenyl)-2-hydroxyethyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-(hydroxymethyl)benzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(5,7-dichloro-2,3-dihydro-1H-inden-1-yl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-cyclopropylbenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2-chloro-3-(trifluoromethyl)benzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(3-chloro-2-(trifluoromethyl)benzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-((2-hydroxyethoxy)methyl)benzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(4-phenoxybenzyl)-5,6-dihydrofuro[2,3-d]thiazole-6-carboxamide;

N-(2,4-dichlorobenzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2-chloro-4-fluorobenzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2-bromo-4,6-dichlorobenzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2,4-dichlorophenethyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2-chloro-3-cyanobenzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(3-(2,4-dichlorophenyl)propyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(1-(2,4-dichlorophenyl)-2-hydroxyethyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-(hydroxymethyl)benzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2,4-dichloro-6-methoxybenzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(5,7-dichloro-2,3-dihydro-1H-inden-1-yl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(2-chloro-3-(trifluoromethyl)benzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(3-fluoro-4-(trifluoromethoxy)benzyl)-5,6-dihydro-4H-cyclopenta[d]thiazole-6-carboxamide;

N-(4-chlorobenzyl)-N-methyl-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2,4-dichlorobenzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2-chloro-4-fluorobenzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2,3-dichlorobenzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2,4-dichlorophenethyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2-chloro-3-cyanobenzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(4-(trifluoromethyl)benzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(3-(2,4-dichlorophenyl)propyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-((S)-1-(2,4-dichlorophenyl)-2-hydroxyethyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-(hydroxymethyl)benzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-((S)-5,7-dichloro-2,3-dihydro-1H-inden-1-yl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2-chloro-3-(trifluoromethyl)benzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-(2-hydroxyethoxy)benzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(3-fluoro-4-(trifluoromethoxy)benzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(4-phenoxybenzyl)-6,7-dihydro-5H-pyrano[2,3-d]thiazole-7-carboxamide;

N-(4-chlorobenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(4-chlorobenzyl)-N-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(3-chloro-2-methylbenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

2-amino-N-(2,4-dichlorobenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichlorobenzyl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

2-bromo-N-(2,4-dichlorobenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichlorobenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2-chloro-4-fluorobenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,3-dichlorobenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,3-dihydro-1H-inden-1-yl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-((R)-1-(2,4-dichlorophenyl)ethyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-2-(trifluoromethyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

2-amino-N-(2,4-dichloro-6-methylbenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

2-bromo-N-(2,4-dichloro-6-methylbenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichlorophenethyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-((S)-1-(2,4-dichlorophenyl)-2-hydroxyethyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-(hydroxymethyl)benzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

2-bromo-N-(2-chloro-3-(trifluoromethyl)benzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2-chloro-3-(trifluoromethyl)benzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(2,4-dichloro-6-(methoxymethyl)benzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(3-fluoro-4-(trifluoromethoxy)benzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

N-(4-phenoxybenzyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxamide;

2-amino-N-(2,4-dichlorobenzyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazole-8-carboxamide;

N-(2,4-dichlorobenzyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazole-8-carboxamide;

2-amino-N-(2,4-dichloro-6-methylbenzyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazole-8-carboxamide;

N-(2,4-dichloro-6-methylbenzyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazole-8-carboxamide;

(R)—N—((S)-1-(2,4-dichlorophenyl)-2-hydroxyethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazole-8-carboxamide; and

(S)—N—((S)-1-(2,4-dichlorophenyl)-2-hydroxyethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazole-8-carboxamide;

or a salt of such a compound.

11. A pharmaceutical composition containing, as active principle the compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

12. A pharmaceutical composition containing, as active principle, a compound of formula (I) according to claim 10 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

13. A method for the treatment of a disease selected from spinal cord injury, stroke, Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, pain, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, lung emphysema, glomerulonephritis, irritable bowel syndrome, psoriasis, atopic dermatitis, Crohn's disease, ulcerative colitis, diabetes mellitus, osteoporosis, and ischemic heart disease, comprising administering to a subject a pharmaceutically active amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.

14. A method for the treatment of a disease selected from spinal cord injury, stroke, Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, pain, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, lung emphysema, glomerulonephritis, irritable bowel syndrome, psoriasis, atopic dermatitis, Crohn's disease, ulcerative colitis, diabetes mellitus, osteoporosis, and ischemic heart disease, comprising administering to a subject a pharmaceutically active amount of a compound according to claim 10 , or a pharmaceutically acceptable salt thereof.

15. The compound of formula (I) according to claim 2 , wherein

m represents 0;

or a salt of such a compound.

16. The compound of formula (I) according to claim 15 , wherein

R 1 represents hydrogen and R 2 represents chloro;

or a salt of such a compound.

17. The compound of formula (I) according to claim 15 , wherein

R 1 and R 2 together represent a —CH 2 CH 2 — group;

or a salt of such a compound.

18. The compound of formula (I) according to claim 15 , wherein

R 5 represents hydrogen;

or a salt of such a compound.

19. The method of claim 13 , wherein the disease is selected from spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, pain, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, lung emphysema, glomerulonephritis, irritable bowel syndrome, psoriasis, atopic dermatitis, Crohn's disease, ulcerative colitis, diabetes mellitus, and osteoporosis.