IP Library › Patent Application 14766923
Patent Application
App. No. 14/766,923

DIFLUPREDNATE EMULSION COMPOSITION CONTAINING ZINC

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Quick Facts
Patent No.
US None
App. No.
14/766,923
Abstract

The present invention relates to an emulsion composition containing difluprednate and zinc. The present invention also relates to a method of stabilizing an emulsion composition containing difluprednate, the method includes preparing an emulsion composition comprising difluprednate and zinc. According to the present invention, a difluprednate-containing emulsion composition having excellent preservative efficacy and excellent stability (photostability and heat stability) can be provided.

Claims (12)

1 . An emulsion composition comprising difluprednate and zinc.

2 . The emulsion composition according to claim 1 , wherein zinc is a zinc salt or a zinc complex.

3 . The emulsion composition according to claim 2 , wherein the zinc salt or zinc complex is at least one selected from the group consisting of zinc sulfate and zinc chloride.

4 . The emulsion composition according to claim 2 , wherein the zinc salt or zinc complex has a concentration as zinc ion of not less than 0.00001 (w/v) % and not more than 0.1 (w/v) %.

5 . The emulsion composition according to claim 3 , further comprising sorbic acid and boric acid.

6 . The emulsion composition according to claim 1 , which is an ophthalmic composition.

7 . A method of stabilizing an emulsion composition comprising difluprednate, the method comprising preparing an emulsion composition comprising difluprednate and zinc.

8 . The method according to claim 7 , wherein zinc is a zinc salt or a zinc complex.

9 . The method according to claim 8 , wherein the zinc salt or zinc complex is at least one selected from the group consisting of zinc sulfate and zinc chloride.

10 . The method according to claim 8 , wherein the zinc salt or zinc complex is added to the emulsion composition at a concentration of not less than 0.00001 (w/v) % and not more than 0.1 (w/v) % as zinc ion.

11 . The method according to claim 9 , further comprising adding sorbic acid and boric acid to the emulsion composition.

12 . The method according to claim 7 , wherein the emulsion composition is an ophthalmic composition.

Assignments (2)
CHANGE OF ADDRESS Recorded Aug 24, 2018
From: SENJU PHARMACEUTICAL CO., LTD.
To: SENJU PHARMACEUTICAL CO., LTD.
Reel/Frame 046835/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2015
From: IEMOTO, SUZUKA; YAMAGUCHI, MASAZUMI; YASUEDA, SHINICHI
To: SENJU PHARMACEUTICAL CO., LTD.
Reel/Frame 036533/0481 →