Immunostimulation agent
The present invention provides Leuconostoc mesenteroides NTM048 strain deposited under accession No. NITE BP-1519, or a mutant strain thereof or a processed bacterium thereof, and a lactobacillus preparation and an immunity (particularly intestinal immunity) stimulant, containing the lactobacillus or a processed bacterium thereof.
1. A method of stimulating immunity in a mammal, comprising administering to the mammal an effective amount of Leuconostoc mesenteroides NTM048 strain deposited under Accession No. NITE BP-1519, a culture medium thereof, wet bacteria thereof, a washed product thereof, freeze-dry powder thereof, heat-killed bacteria thereof, dry-killed bacteria thereof, chemical-killed bacteria thereof, bacteria disrupture product thereof or fermentation product obtained by inoculating NTM048 strain.
2. The method according to claim 1 , wherein the Leuconostoc mesenteroides NTM048 strain, a culture medium thereof, wet bacteria thereof, a washed product thereof, freeze-dry powder thereof, heat-killed bacteria thereof, dry-killed bacteria thereof, chemical-killed bacteria thereof, bacteria disrupture product thereof or fermentation product obtained by inoculating NTM048 strain is administered in a lactobacillus preparation to the mammal.
3. The method according to claim 2 , wherein the lactobacillus preparation is a food or a food additive.
4. The method according to claim 2 , wherein the lactobacillus preparation is a pharmaceutical composition.
5. The method according to claim 2 , wherein the lactobacillus preparation is a feed or a feed additive.
6. The method according to claim 2 , wherein the lactobacillus preparation further comprises other lactobacillus , a culture medium thereof, wet bacteria thereof, a washed product thereof, freeze-dry powder thereof, heat-killed bacteria thereof, dry-killed bacteria thereof, chemical-killed bacteria thereof, bacteria disrupture product thereof, an extract thereof or fermentation product obtained by inoculating the lactobacillus.
7. The method according to claim 6 , wherein the other lactobacillus is at least one kind selected from the group consisting of Lactobacillus bacteria, Streptococcus bacteria, Leuconostoc bacteria, Pediococcus bacteria, Lactococcus bacteria, Enterococcus bacteria and Bifidobacterium bacteria.
8. The method according to claim 2 , wherein the lactobacillus preparation further comprises a microorganism other than lactobacillus , a culture medium thereof, wet bacteria thereof, a washed product thereof, freeze-dry powder thereof, heat-killed bacteria thereof, dry-killed bacteria thereof, chemical-killed bacteria thereof, bacteria disrupture product thereof, an extract thereof or fermentation product obtained by inoculating the lactobacillus.
9. The method according to claim 8 , wherein the microorganism other than lactobacillus is at least one kind selected from the group consisting of yeast, Bacillus bacteria, butyric acid bacteria and fungi.
10. The method according to claim 2 , wherein the lactobacillus preparation further comprises (a) other lactobacillus , a culture medium thereof, wet bacteria thereof, a washed product thereof, freeze-dry powder thereof, heat-killed bacteria thereof, dry-killed bacteria thereof, chemical-killed bacteria thereof, bacteria disrupture product thereof, an extract thereof or fermentation product obtained by inoculating the lactobacillus and (b) a microorganism other than lactobacillus , a culture medium thereof, wet bacteria thereof, a washed product thereof, freeze-dry powder thereof, heat-killed bacteria thereof, dry-killed bacteria thereof, chemical-killed bacteria thereof, bacteria disrupture product thereof, an extract thereof or fermentation product obtained by inoculating the microorganism.
11. The method according to claim 10 , wherein (a) the other lactobacillus is at least one kind selected from the group consisting of Lactobacillus bacteria, Streptococcus bacteria, Leuconostoc bacteria, Pediococcus bacteria, Lactococcus bacteria, Enterococcus bacteria and Bifidobacterium bacteria, and (b) the microorganism other than lactobacillus is at least one kind selected from the group consisting of yeast, Bacillus bacteria, butyric acid bacteria and fungi.
12. The method according to claim 2 , wherein the mammal has a disease relating to intestinal immunity.
13. The method according to claim 12 , wherein the disease relating to intestinal immunity is selected from the group consisting of allergic diseases, infections, inflammatory bowel diseases, and autoimmune diseases.
14. The method according to claim 9 , wherein the butyric acid bacteria is Clostridium butyricum.
15. The method according to claim 11 , wherein the butyric acid bacteria is Clostridium butyricum.