2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
1. A compound which is (2S,3R,4R)-1-acetyl-2-cyclopropyl-3-methyl-4-((4-methylpyrimidin-2-yl)amino)-1,2,3,4-tetrahydroquinoline-6-carboxamide, represented by the formula:
or a salt thereof.
2. The compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition which comprises the compound or a pharmaceutically acceptable salt thereof according to claim 2 and one or more pharmaceutically acceptable carriers, diluents or excipients.
4. The compound according to claim 1 in the form of a free base.
5. A pharmaceutical composition which comprises the compound according to claim 4 and one or more pharmaceutically acceptable carriers, diluents or excipients.