Methods for the treatment of mitochondrial diseases associated with a mutation in
The disclosure provides methods of preventing, ameliorating or treating disruption of mitochondrial function and symptoms thereof. The methods provide administering aromatic-cationic peptides in effective amounts to prevent, treat or ameliorate the disruption of mitochondrial oxidative phosphorylation in a cell such as that found in a subject suffering from, or predisposed to a mitochondrial disease or disorder. In some embodiments, the methods comprise administering to a subject suffering from, or at risk for a mitochondrial disease or disorder, an effective amount of an aromatic-cationic peptide to subjects in need thereof.
1. A method for ameliorating a disease selected from the group consisting of Leigh syndrome, Alpers' disease, ataxia-neuropathy disorders, and progressive external ophthalmoplegia in a subject in need thereof, the method comprising: administering to the subject a therapeutically effective amount of the peptide D-Arg-2′,6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof, wherein the Leigh syndrome is associated with a loss-of-function mutation in the SURF 1 gene resulting in a disruption of mitochondrial oxidative phosphorylation due to impairment of the complete assembly of at least one mitochondrial complex selected from the group consisting of Complex I; Complex II; Complex III; Complex IV, and the Alpers' disease, ataxia-neuropathy disorders, and progressive external ophthalmoplegia are associated with a loss-of-function mutation in the POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation.
2. The method of claim 1 , wherein the peptide is administered orally, topically, systematically, intravenously, subcutaneously, intraperitoneally, or intramuscularly.
3. The method of claim 1 , wherein the disease is Leigh syndrome associated with a loss-of-function mutation in the SURF 1 gene resulting in a disruption of mitochondrial oxidative phosphorylation due to impairment of the complete assembly of at least one mitochondrial complex selected from the group consisting of Complex I; Complex II; Complex III; Complex IV.
4. The method of claim 1 , wherein the disease is Alpers' disease associated with a loss-of-function mutation in the POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation.
5. The method of claim 1 , wherein the disease is ataxia-neuropathy disorders associated with a loss-of-function mutation in the POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation.
6. The method of claim 1 , wherein the disease is progressive external ophthalmoplegia associated with a loss-of-function mutation in the POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation.