Methods of improving microvascular integrity
View Patent ↗The disclosure relates to methods of preserving or improving microvascular integrity in a patient in need thereof comprising administering pirfenidone therapy to the patient.
1. A method for preserving or improving microvascular integrity or treating a microvascular disorder in a patient suffering from bronchiolitis obliterans, comprising administering pirfenidone to the patient, wherein the pirfenidone is administered to the patient prior to diagnosis/onset/showing signs or symptoms of fibrosis.
2. A method for preserving or improving microvascular integrity or treating a microvascular disorder in a patient suffering from bronchiolitis obliterans, comprising administering pirfenidone to the patient, wherein the pirfenidone is administered three times per day, with food.
3. A method for preserving or improving microvascular integrity or treating a microvascular disorder in a patient suffering from bronchiolitis obliterans, comprising administering pirfenidone to the patient, wherein the amount effective to preserve or improve microvascular integrity or treat the microvascular disorder is about 2400 or 2403 mg/day and wherein the pirfenidone is administered three times per day, with food.