IP Library Granted Patent US 9,394,285
Granted Patent B2
US 9,394,285 · App. 14/773,954 · Granted Jul 19, 2016

Indole and indazole compounds that activate AMPK

Inventors: Samit Kumar Bhattacharya (Waltham, MA); Kimberly O'Keefe Cameron (Cambridge, MA); Matthew Scott Dowling (Groton, CT); David Christopher Ebner (Somerville, MA); David James Edmonds (Arlington, MA); Dilinie Prasadhini Fernando (Niantic, CT); Kevin James Filipski (Reading, MA); Daniel Wei-Shung Kung (Salem, CT); Esther Cheng Yin Lee (Brookline, MA); Aaron Christopher Smith (North Providence, RI); Meihua Mike Tu (Acton, MA)
Assignee: Pfizer Inc.
C07D405/12A61K31/4439C07D401/04C07D401/12C07D403/12
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Quick Facts
Patent No.
US 9,394,285
App. No.
14/773,954
Granted
Jul 19, 2016
Kind
B2
Abstract

The present invention relates to indole and indazole compounds of Formula (I) that activate 5′ adenosine monophosphate-activated protein kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of AMPK.

Claims (12)

1. A compound of structure

or a pharmaceutically acceptable salt thereof.

2. A compound of structure

or a pharmaceutically acceptable salt thereof.

3. A compound of structure

or a pharmaceutically acceptable salt thereof.

4. A compound of structure

or a pharmaceutically acceptable salt thereof.

5. A compound of structure

or a pharmaceutically acceptable salt thereof.

6. A compound of structure

or a pharmaceutically acceptable salt thereof.

Assignments (1)
ASSIGNEE ADDRESS CORRECTION Recorded Mar 20, 2023
From: PFIZER INC.
To: PFIZER INC.
Reel/Frame 063119/0087 →
Priority Claims (1)
WO PCT/IB2013/052604 · Apr 1, 2013 · international
Continuity (2)
Continuation In Part 13831588 · Mar 15, 2013
Related Publication 20160016940A1 · Jan 21, 2016