The present invention provides compounds of Formula I and Formula II: or pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXRs), and compositions comprising any of such novel compounds and methods of use thereof. These compounds are useful as medicaments for treatment and/or prophylaxis for diseases or conditions related to activity of LXRs.
1. A compound of the formula I or II,
or a pharmaceutically acceptable salt or solvate thereof, wherein
Ring C is selected from oxazolyl and triazolyl;
Ring D is selected from phenyl and pyridyl;
A is phenyl or a 5 or 6 membered heteroaryl, wherein the phenyl is optionally fused to a 5 or 6 membered heterocyclyl or 5 or 6 membered heteroaryl, wherein A is optionally substituted with 1, 2, or 3 R A groups, wherein
each R A is independently R A1 , —C 1 -C 6 alkyl-R A1 , C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, pyrrolidinone, or pyrrolidinyl, wherein the cycloalkyl is optionally substituted with 1, 2, 3, or 4 groups that are independently R A1 , C 1 -C 6 alkyl, or —C 1 -C 6 alkyl-R A1 , wherein
each R A1 is independently halogen, cyano, nitro, —OR, —NR 2 , —SR, —C(O)R, or —C(O)OR;
alternatively, two R A 's on adjacent carbons can join to form a —O—CH 2 —O—, —O—CH 2 —CH 2 —, —O—CH 2 —CH 2 —O—, —CH 2 —CH 2 —CH 2 —, or —O—CF 2 —O—;
R B1 is hydrogen, C 1-3 alkyl, halo, cyclopropyl, or C 1-3 haloalkyl;
R B2 is hydrogen, halo, —CN, —C(O)NR 2 , or C 1-3 alkyl;
R B3 is C 1-6 alkyl, C 1-6 haloalkyl, or C 3-6 cycloalkyl, each of which is substituted with 0-1 R B5 ; hydrogen; cyano; —C(O)—R; —C(O)NR 2 ; —NHC(O)R; —NHSO 2 R; or a 5-membered ring heteroaryl, wherein the heteroaryl ring consists of carbon atoms and 1, 2, or 3 heteroatoms independently selected from the group consisting of N, S, and O and is substituted with 0-1 R;
R B4 is H, halogen, C 1-3 alkyl, C 1-3 haloalkyl, —C 3 -C 6 cycloalkyl, or —O—C 1-3 alkyl;
R B5 is cyano, —O—R, —C(O)NR 2 , —C(O)OR, —NR 2 , —OC(O)—NH 2 , —S(O) 2 NR 2 , or a 5-membered ring heteroaryl, wherein the heteroaryl ring consists of carbon atoms and 1, 2, or 3 heteroatoms independently selected from the group consisting of N, S, and O;
R C is hydrogen, halogen, cyano, or nitro;
n is 0, 1, 2, 3, or 4; and
each R D1 and R D2 are independently R D3 , C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R D3 , C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 3 -C 8 cycloalkyl, wherein the cycloalkyl is each optionally substituted with 1, 2, 3, or 4 groups that are independently R D3 , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or —C 1 -C 6 alkyl-R D3 , wherein
each R D3 is independently halogen, cyano, —OR, —NR 2 , —SR, —C(O)R, —C(O)OR, —C(O)NR 2 , —S(O)R, —S(O) 2 R, —S(O)NR 2 , —S(O) 2 NR 2 , —OC(O)R, —OC(O)OR, —OC(O)NR 2 , —N(R)C(O)R, —N(R)C(O)OR, —N(R)C(O)NR 2 , —N(R)S(O) 2 R, —N(R)S(O) 2 OR, —N(R)S(O) 2 NR 2 , or —S(O) 2 N(R)C(O)NR 2 ; and
R L is hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, —C(O)R, —C(O)OR, —C(O)NR 2 , —S(O)R, —S(O) 2 R, —S(O)OR, —S(O) 2 OR, —S(O)NR 2 , or —S(O) 2 NR 2 ;
wherein
each R group is independently hydrogen, C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R 2 , C 1 -C 6 haloalkyl, —C 1 -C 6 haloalkyl-R 2 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 3 -C 8 cycloalkyl, or —C 1 -C 6 alkyl-C 3-6 cycloalkyl; or for any —C(O)NR 2 or —NR 2 , alternatively, the two Rs along with the N to which they attach may form morpholinyl, pyrrolidinyl, or piperdinyl; and
wherein
each R 2 is independently cyano, —OR 3 , —C(O)NH 2 , —N(R 3 ) 2 , —N(R 3 )S(O) 2 R 3 , —N(R 3 )S(O) 2 OR 3 , or —N(R 3 )S(O) 2 N(R 3 ) 2 , wherein each R 3 is independently hydrogen, C 1 -C 6 alkyl, C 3-6 cycloalkyl, or C 1 -C 6 haloalkyl.
2. The compound of formula I or II,
or a pharmaceutically acceptable salt or solvate thereof, wherein
Ring C is selected from oxazolyl and triazolyl;
Ring D is selected from phenyl and pyridyl;
A is phenyl, pyridinyl or pyrimidinyl, wherein A is optionally substituted with 1, 2, or 3 R A groups, wherein
each R A is independently halogen, —CN, C 1-6 alkyl, C 1-6 haloalkyl, C 3 -C 6 cycloalkyl, —O—C 1-6 haloalkyl, —O—C 1-6 alkyl, —CO—C 1-6 alkyl, —O—C 3-6 cycloalkyl, pyrrolidinone, pyrrolidinyl, —C(O)O—C 1-6 alkyl, or —NR 2 ; or
alternatively, two adjacent R A 's join to form —O—CH 2 —O— or —O—CF 2 —O—;
R B1 is C 1-3 alkyl, C 1-3 haloalkyl, or cyclopropyl;
R B2 is H, halogen, —CN, —C(O)NR 2 , or —C 1-3 -alkyl;
R B3 is C 1-6 alkyl, C 1-6 haloalkyl, or C 3-6 cycloalkyl, each of which is substituted with 0-1 R B5 ; hydrogen; cyano; —C(O)—R; —C(O)NR 2 ; —NHC(O)R; —NHSO 2 R; or a 5-membered ring heteroaryl, wherein the heteroaryl ring consists of carbon atoms and 1, 2, or 3 heteroatoms independently selected from the group consisting of N, S, and O and is substituted with 0-1 R;
R B4 is H, halogen, C 1-3 alkyl, C 1-3 haloalkyl, cyclopropyl, or —O—C 1-3 alkyl;
R B5 is cyano, —O—R, —C(O)NR 2 , —C(O)OR, —NR 2 , —OC(O)—NH 2 , or a 5-membered ring heteroaryl, wherein the heteroaryl ring consists of carbon atoms and 1, 2, or 3 heteroatoms selected from the group consisting of N, S, and O;
each R is independently hydrogen, C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R 2 , C 1 -C 6 haloalkyl, —C 1 -C 6 haloalkyl-R 2 , C 3 -C 6 cycloalkyl, or —C 1 -C 6 alkyl-C 3-6 cycloalkyl; or for any —C(O)NR 2 or —NR 2 , alternatively, the two Rs along with the N to which they attach may form morpholinyl, pyrrolidinyl, or piperdinyl;
each R 2 is independently —OH, —C(O)NH 2 , or cyano,
n is 0, 1, 2, 3, or 4; and
R D1 is —S(O) 2 —C 1-3 alkyl, —S(O) 2 N(R 3 ) 2 , —C(CH 3 ) 2 —C(O)NH 2 , —C(CH 3 ) 2 —CN, or -cyclopropyl-C(O)NH 2 ;
each R D2 is independently halogen or —CH 2 OH;
R 3 is H, C 1-3 alkyl, cyclopropyl, or C 1-3 haloalkyl;
R C is hydrogen or halogen; and
R L is absent, hydrogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or C 1 -C 6 haloalkyl.
3. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
R B1 is —C 1-3 -alkyl, —C 1-3 -haloalkyl, or cyclopropyl;
R B2 is H, halogen, CN, or methyl;
R B3 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, each of which is substituted with 0-1 R B5 ; cyano, —C(O)NR 2 , —NHC(O)R, or —NHSO 2 R; and
R B4 is H, halogen, methyl, —CF 3 , cyclopropyl, or —O—C 1-3 alkyl.
4. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
R B5 is cyano, —O—R, —C(O)NR 2 , —C(O)OR, or —OC(O)—NH 2 ; and
each R is independently, hydrogen, C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R 2 , C 1 -C 6 haloalkyl, —C 1 -C 6 haloalkyl-R 2 , C 3 -C 6 cycloalkyl, or —C 1 -C 6 alkyl-C 3-6 cycloalkyl, or for —C(O)NR 2 , alternatively, two Rs along with the N to which they attach may form morpholinyl, pyrrolidinyl, or piperdinyl.
5. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
A is phenyl or pyridinyl, wherein A is optionally substituted with 1, 2, or 3 R A groups.
6. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
A is phenyl optionally substituted with 1, 2, or 3 R A groups.
7. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
Ring C is selected from oxazolyl, and
R L is hydrogen or methyl.
8. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
Ring C is selected from triazolyl, and
R L is hydrogen.
9. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
Ring D is selected from phenyl.
10. The compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein
each R D1 is —S(O) 2 -methyl, —S(O) 2 N(R 3 ) 2 , —C(CH 3 ) 2 —C(O)NH 2 , -cyclopropyl-C(O)NH 2 ;
R 3 is H or C 1-3 alkyl.
11. A compound selected from Examples 1-448 listed below, or a pharmaceutically acceptable salt or solvate thereof:
Ex #
Structure
Name
1
1,1-difluoro-1-(1-methy1-5-(3′- (methylsulfony1)-3-(5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)biphenyl-4-yl)-1H-pyrazol- 3-yl)propan-2-ol
2
(4′-(3-(1,1-difluoropropyl)-1-methyl- 1H-pyrazol-5-yl)-3-fluoro-5- (methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)biphenyl-4-yl)-1H-pyrazol
3
1,1-difluoro-1-(5-(3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- 3-(5-(4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl)-1- methyl-IH-pyrazol-3-yl)-2- methylpropan-2-ol
4
2,2-difluoro-2-(1-methyl-5-(3′- (methylsulfonyl)-3-(5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)biphenyl-4-yl)-1H-pyrazol- 3-yl)acetamide
5
((4′-(3-(1,1-difluoroethyl)-1,4- dimethyl-1H-pyrazol-5-yl)-3-fluoro-5- (methylsulfonyl)-3′-(5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)biphenyl-4-yl)methanol
6
1,1-difluoro-1-(5-(3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- 3-(5-(4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)propan-2-ol
7
1,1-difluoro-2-methyl-1-(1-methyl-5- 3′-(methylsulfonyl)-3-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)biphenyl-4-yl)-1H-pyrazol- 3-yl)propan-2-ol
8
2,2-difluoro-2-(5-(3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- 3-(5-(4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)acetamide
9
1-(4-(3-(1,1-difluoropropyl)-1-methyl- 1H-pyrazol-5-yl)-3′- methylsulfonyl)biphenyl-3-yl)-5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazole
10
1-(4-(3-(1,1-difluoroethyl)-1,4- dimethyl-1H-pyrazol-5-yl)-3′- (methylsulfonyl)biphenyl-3-yl)-5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazole
11
(4′-(3-(1,1-difluoroethyl)-1,4-dimethyl- 1H-pyrazol-5-yl)-3-(methylsulfonyl)- 3′-(5-(4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl)methanol
12
2-methyl-2-{4′-[1-methyl-3- (trifluoromethyl)-1H-pyrazol-5-yl]-3′- (5-{4-[(trifluoromethyl)oxy]phenyl} 1H-1,2,3-triazol-1-yl)biphenyl-3- yl}propanamide
13
[3-chloro-5-(methylsulfonyl)-4′-[1- methyl-3-(trifluoromethyl)-1H-pyrazol- 5-yl]-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
14
1-{3′-(methylsulfonyl)-4-[1-methyl-3- (trifluoromethyl)-1H-pyrazol-5- yl]biphenyl-3-y1}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
15
(3-fluoro-4′-(1-methyl-3- (trifluoromethyl)-1H-pyrazol-5-yl)-5- methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)biphenyl-4-yl)methanol
16
1-[4-{3-[1,1-difluoro-2- (methyloxy)ethyl]-1-methyl-1H- pyrazol-5-yl}3′- (methylsulfonyl)biphenyl-3-yl]-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
17
[4′-{3-[1,1-difluoro-2- methyloxy)ethyl]-1-methyl-1H- pyrazol-5-yl}-3-fluoro-5- (methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
18
1-{4-[3-(1,1-difluoroethyl)-1-methyl- 1H-pyrazol-5-yl]-3′- (methylsulfonyl)bipheny-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
19
4′-[3-(1,1-difluoroethyl)-1-methyl-1H- pyrazol-5-yl]-N,N-dimethyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
20
4′-[3-(1,1-difluoroethyl)-1-methyl-1H- pyrazol-5-yl]-N-methyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
21
{4′-[3-(1,1-difluoroethyl)-1-methyl-1H- pyrazol-5-yl]-3-fluoro-5- methylsulfonyl)-3′-(5-{4- trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
22
1-{4-[3-(difluoromethyl)-1-methyl-1H- pyrazol-5-yl-3′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
23
{4′-[3-(difluoromethyl)-1-methy1-1H- pyrazol-5-yl]-3-fluoro-5- methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
24
2-(5-(3-(5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol- 3-yl)-2,2-difluoroethanol
25
2,2-difluoro-2-(1-methyl-5-(3′- (methylsulfonyl)-3-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)ethanol
26
2,2-difluoro-2-(5-(3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- 3-(5-(4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazol-1-yl)-[1,1′-biphenyl]-4- yl)-1-methyl-1H-pyrazol-3-yl)ethanol
27
2,2-difluoro-2-(5-(3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- 3-(5-(4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazol-1-yl)-[1,1′-biphenyl]-4- yl)-1-methyl-1H-pyrazol-3-yl)-N-(1- hydroxy-2-methylpropan-2- yl)acetamide
28
2,2-difluoro-N-(1-hydroxy-2- (methylsulfonyl)-3-(5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)acetamide
29
2-((2,2-difluoro-2-(1-methyl-5-(3′- (methylsulfonyl)-3-(5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)ethyl)amino)ethanol
30
2,2-difluoro-2-(1-methyl-5-(3′- (methylsulfonyl)-3-(5-(4- trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)acetonitrile
31
1-(5-(3-(5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol- 3-yl)-1,1-difluoro-2-methylpropan-2-ol
32
2-(5-(3-(5-(2,4-dichlorophenyl)-1H- 1,2,3-triazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-2,2-difluoroacetamide
33
1-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- 1,2,3-triazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-1,1-difluoro-2- methylpropan-2-ol
34
1-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- 1,2,3-triazol-1-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-1,1-difluoro-2- methylpropan-2-ol
35
2-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- 1,2,3-triazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-2,2-difluoroethanol
36
2-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-2,2-difluoroethanol
37
N-(1-cyano-1-methylethyl)-1-methyl- 5-[3′-(methylsulfonyl)-3-(5-{4- [(trifluoromethyl)oxy]phenyl1-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl]-1H- pyrazole-3-carboxamide
38
N,N,1-trimethyl-5-[3′- (methylsulfonyl)-3-(5-{4- [(trifluoromethyl)oxy]phenyl]-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl]-1H- pyrazole-3-carboxamide
39
1-methyl-5-[3′-(methylsulfonyl)-3-(5- {4-[(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl]-N- (2,2,2-trifluoroethyl)-1H-pyrazole-3- carboxamide
40
N-(1,1-dimethylethyl)-1-methyl-5-[3′- (methylsulfonyl)-3-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl]-1H- pyrazole-3-carboxamide
45
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
46
2-(5-(3-(2-cyclopropyl-4-(2,2- difluorobenzo[d][1,3]dioxol-5- yl)oxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
47
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetonitrile
48
1,1-difluoro-2-methyl-1-(1-methyl-5- (3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 3′-(methylsulfonyl)biphenyl-4-yl)-1H- pyrazol-3-yl)propan-2-ol
49
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroethanol
50
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N-methylacetamide
51
(4′(3-(difluoro(1,3,4-oxadiazol-2- yl)methyl)-1-methyl-1H-pyrazol-5-yl)- 3′-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3-fluoro-5- (methylsulfonyl)biphenyl-4- yl)methanol
52
(4′-(3-(difluoro(4H-1,2,4-triazol-3- yl)methyl)-1-methyl-1H-pyrazol-5-yl)- 3′-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3-fluoro-5- (methylsulfonyl)biphenyl-4- yl)methanol
53
2-methyl-5-(4-(1-methyl-3- (trifluoromethyl)-1H-pyrazol-5-yl)-3′- (methylsulfonyl)biphenyl-3-yl)-4-(4- (trifluoromethoxy)phenyl)Oxazole
54
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)propan-2-ol
55
N-(2-cyanopropan-2-yl)-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazole-3-carboxamide
56
5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazole-3-carboxamide
57
(3′-(4-(42,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3-fluoro-4′-(1- methyl-3-(oxazol-5-yl)-1H-pyrazol-5- yl)-5-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)methanol
58
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)acetonitrile
59
(S)-2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)propanenitrile
60
1-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)cyclopropanecarbonitrile
61
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)acetamide
62
2-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2- methylpropan-1-ol
63
2-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2- methylpropanamide
64
3-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,3- dimethylbutan-2-ol
65
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2- methylpropanamide
66
3-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,3- dimethylbutan-2-ol
67
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2- methylpropanenitrile
68
(4′-(3-(2-(1,3,4-oxadiazol-2-yl)propan- 2-yl)-1-methyl-1H-pyrazol-5-yl)-3′-(4- (2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3-fluoro-5- (methylsulfonyl)biphenyl-4- yl)methanol
69
1-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-N,N- dimethylmethanesulfonamide
70
2,2-difluoro-2-(5-(3′-fluoro-4′- (hydroxymethyl)-3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 5′-(methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)acetamide
71
2-(5-(3-(4-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-5-yl)-3′- fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
72
2-(5-(3-(4-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-5-yl)-3′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
73
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
74
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
75
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroaceticacid
76
2-(5-(3-(4-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroethanol
77
2-(5-(3-(4-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-5-yl)-3′- fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroethanol
78
2-(5-(3-(4-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-5-yl)-3′- fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N-methylacetamide
79
2-(5-(3-(4-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-5-yl)-3′- fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N,N-dimethylacetamide
80
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N,N-dimethylacetamide
81
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- OH(hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- 1-morpholinoethanone
82
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N-isopropylacetamide
83
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,l′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)-2,2-difluoro-1- (pyrrolidin-l-yl)ethanone
84
N-tert-butyl-2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2- difluoroacetamide
85
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N-methylacetamide
86
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)-2,2-difluoro-N-(2- hydroxyethyl)acetamide
87
N-(cyclopropylmethyl)-2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)-2,2-difluoroacetamide
88
N-cyclopropyl-2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)-2,2-difluoroacetamide
89
N-(2-amino-2-oxoethyl)-2-(5-(3-(4- (2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)-2,2-difluoroacetamide
90
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)-2,2-difluoro-N-(2,2,2- trifluoroethyl)acetamide
91
2-(5-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2,2-difluoro- N-methylacetamide
92
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)propan-2-ol
93
(3-fluoro-4′-(1-methyl-3-1- (trifluoromethyl)-1H-pyrazol-5-yl)-3′- (2-methyl-4-(4-(trifluoromethoxy) phenyl)oxazol-5-yl)-5-(methylsulfonyl) biphenyl-4-yl)methanol
94
4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-5-(4-(3-(1,1-difluoroethyl)-1- methyl-1H-pyrazol-5-yl)-3′- (methylsulfonyl)biphenyl-3-yl)-2- methyloxazole
95
(3′-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-4′-(3-(1,1- difluoroethyl)-1-methyl-1H-pyrazol-5- yl)-3-fluoro-5-(methylsulfonyl) biphenyl-4-yl)methanol
96
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-(methylsulfonyl) biphenyl-4-yl)-1-methyl-1H-pyrazol-3- yl)-2-methylpropanamide
97
2-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-1- methyl-1H-pyrazol-3-yl)-2- methylpropanenitrile
98
(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1- methyl-1H-pyrazol-3-yl)methanol
99
(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazol- 3-yl)methanol
100
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)-1,3,4-oxadiazole
101
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)ethanol
102
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3-yl)ethanol
103
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)ethanol
104
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)ethanol
105
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3′-fluoro-4′-(hydroxymethyl)- 5′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1-methyl- 1H-pyrazol-3-yl)-2,2-difluoroethanol
106
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3-yl)-2,2- difluoroethanol
107
N-cyclopropyl-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazole- 3-carboxamide
108
N-cyclopropyl-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2-methyloxazol-5- yl)-3′-fluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazole-3- carboxamide
109
N-(cyclopropylmethyl)-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazole- 3-carboxamide
110
N-(cyclopropylmethyl)-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazole-3-carboxamide
111
5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)-1-methyl-N-(2,2,2-trifluoroethyl)- 1H-pyrazole-3-carboxamide
112
5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-N-(2,2,2- trifluoroethyl)-1H-pyrazole-3-carboxamide
113
N-(tert-butyl)-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazole-3-carboxamide
114
N-(tert-butyl)-5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′- fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)-[1,1′-biphenyl]- 4-yl)-1-methyl-1H-pyrazole-3-carboxamide
115
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H- pyrazol-3-yl)propanenitrile
116
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′- methylsulfonyl)[1,1′-biphenyl]-4-yl)-1- methyl-1H-pyrazol-3-yl)propanenitrile
117
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)[1,1′-biphenyl]-4- yl)-1-methyl-1H-pyrazol-3-yl)propanenitrile
118
1-(5-(3-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazol- 3-yl)cyclopropanecarbonitrile
119
2-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)41,1′-biphenyl]-4-yl)-1-methyl- 1H-pyrazol-3-yl)acetamide
120
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3-yl)- 2-methylpropan-2-ol
121
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)41,1′-biphenyl]-4-yl)-1- methyl-1H-pyrazol-3-yl)-2-methylpropan-2-ol
122
5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazole- 3-carbonitrile
123
5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazole-3- carbonitrile
124
N-(2-hydroxy-2-methylpropyl)-1-methyl-5-(3- (2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)- 1H-pyrazole-3-carboxamide
125
(3-chloro-4′-(1-methyl-3-(trifluoromethyl)-1H- pyrazol-5-yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 5-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methanol
126
4′-(1-methyl-3-(trifluoromethyl)-1H-pyrazol- 5-yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-[1,1′-biphenyl]-3-sulfonamide
127
N-methyl-4′-(1-methyl-3-(trifluoromethyl)- 1H-pyrazol-5-yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- [1,1′-biphenyl]-3-sulfonamide
128
2,2-difluoro-2-(1-methyl-5-(3-(2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazol-5-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)- 1H-pyrazol-3-yl)acetamide
129
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)ethylcarbamate
130
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)ethylcarbamate
131
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)ethylcarbamate
132
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)ethylcarbamate
133
1-(5-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1-methyl-1H-pyrazol-3- yl)ethanone
300
1-{3′-(methylsulfonyl)-4-[5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl]biphenyl- 3-yl}-5-{4-[(trifluoromethyl)oxy]phenyl}- 1H-1,2,3-triazole
301
[3-fluoro-5-(methylsulfonyl)-4′45-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl]-3′-(5- {4-[(trifluoromethyl)oxy]phenyl}-1H-1,2,3- triazol-1-yl)biphenyl-4-yl]methanol
302
[3-chloro-5-(methylsulfonyl)-4′-[5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl]-3′-(5- {4-[(trifluoromethyl)oxy]phenyl}-1H-1,2,3- triazol-1-yl)biphenyl-4-yl]methanol
303
2-methyl-2-{4′-[5-methyl-3-(trifluoromethyl)- 1H-pyrazol-1-yl]-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H-1,2,3- triazol-1-yl)biphenyl-3-yl}propanamide
304
1-{4-[3-(1,1-difluoroethyl)-5-methyl-1H-pyrazol- 1-yl]-3′-(methylsulfonyl)biphenyl-3-yl}-5- {4-[(trifluoromethyl)oxy]phenyl}-1H-1,2,3-triazole
305
{4′-3-(1,1-difluoroethyl)-5-methyl-1H-pyrazol-1- yl]-3-fluoro-5-(methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H-1,2,3-triazol- 1-yl)biphenyl-4-}methanol
306
1-{4-[5-(1,1-difluoroethyl)-3-methyl-1H-pyrazol-1- yl]-3′-(methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H-1,2,3-triazole
307
5-{3′-(methylsulfonyl)-4-[5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl]biphenyl- 3-yl}-4-{4-[(trifluoromethyl)oxy]phenyl}- 1,3-oxazole
308
1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol- 5-yl)-3′-(methylsulfonyl)biphenyl-4-yl)- 1H-pyrazole-3-carboxamide
309
2-methyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)-[1,1′- biphenyl]-3-yl)-4-(4- (trifluoromethoxy)phenyl)oxazole
310
4-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)-1-1,1′-biphenyl]- 3-yl)-2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazole
311
4-(4-(5-ethoxy-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3-yl)-2- (trifluoromethoxy)phenyl)oxazole
312
4-(4-(5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3-yl)-2-methyl- 5-(4-(trifluoromethoxy)phenyl)oxazole
313
(4′-(3-(1,1-difluoroethyl)-1H-pyrazol-1-yl)-3- fluoro-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-5-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)methanol
314
(5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3-(2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)phenyl)-3-(methylsulfonyl)pyridin-2-yl)methanol
315
(4′-(3-cyclopropyl-1H-pyrazol-1-yl)-3-fluoro-3′-(2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazol-5-yl)- 5-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methanol
316
2-(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-1H-pyrazol- 3-yl)propan-2-ol
317
2-(1-(3′-fluoro-4′-(hydroxymethyl)-3-(2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazol-5-yl)-5′- (methylsulfonyl)biphenyl-4-yl)-1H-pyrazol-3- yl)propan-2-ol
318
1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-3′-(methylsulfonyl)biphenyl-4-yl)- 1H-H-pyrazole-3-carbonitrile
319
1-(3′-fluoro-4′-(hydroxymethyl)-3-(2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazol-5-yl)-5′- (methylsulfonyl)biphenyl-4-yl)-1H-pyrazole-3- carbonitrile
320
1-(3′-fluoro-4′-(hydroxymethyl)-3-(2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazol-5-yl)-5′- (methylsulfonyl)biphenyl-4-yl)-1H-pyrazole- 3-carboxamide
321
(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-1H-pyrazol- 3-yl)methanol
322
(3-fluoro-4′-(3-(hydroxymethyl)-1H-pyrazol-1-yl)-3′- (2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-5-(methylsulfonyl)biphenyl-4-yl)methanol
323
(4′-(5-cyclopropyl-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3-fluoro-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-5- (methylsulfonyl)biphenyl-4-yl)methanol
324
5-(4-(5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3-yl)-2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazole
325
(3′-(4-(4-(difluoromethoxy)phenyl)-2- methyloxazol-5-yl)-3-fluoro-4′-(5-methyl- 3-(trifluoromethyl)-1H-pyrazol-1-yl)-5- (methylsulfonyl)biphenyl-4-yl)methanol
326
(3′-(4-(4-(difluoromethoxy)phenyl)-2-methyloxazol- 5-yl)-4′-(5-methyl-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3-(methylsulfonyl)biphenyl-4-yl)methanol
327
4(4-(difluoromethoxy)phenyl)-2-methyl-5-(4-(5- methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-3′- methylsulfonyl)biphenyl-3-yl)oxazole
328
4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-methyl- 5-(4-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)biphenyl-3-yl)oxazole
329
(3′-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3-fluoro-4′-(5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)-5- (methylsulfonyl)biphenyl-4-yl)methanol
330
difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-4′(5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)- 3-(methylsulfonyl)biphenyl-4-yl)methanol
331
2-methyl-5-(4-(5-methyl-3-(trifluoromethyl)- 1H-pyrazol-1-yl)-3′-(methylsulfonyl)biphenyl- 3-yl)-4-(4-(trifluoromethoxy)phenyl)oxazole
332
(3-fluoro-4′-(5-methyl-3-(trifluoromethyl)- 1H-pyrazol-1-yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 5-(methylsulfonyl)biphenyl-4-yl)methanol
333
(4′-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-3-(methylsulfonyl)biphenyl-4-yl)methanol
334
5-(3′-fluoro-5′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl-3- yl)-2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazole
335
(3-fluoro-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
336
(3′-(4-(4-chlorophenyl)-2-methyloxazol-5-yl)-3- fluoro-5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
337
4-(2,4-dichlorophenyl)-2-methyl-5-(3′- (methylsulfonyl)-4-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-3-yl)oxazole
338
2-cyclopropyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 3-yl)-4-(4-(trifluoromethoxy)phenyl)oxazole
339
(3′-(2-cyclopropyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 3-fluoro-5-(methylsulfonyl)-4′-(3- (trifluoromethyl)-1H-pyrazol-1- yl)biphenyl-4-yl)methanol
340
2-isopropyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 3-yl)-4-(4-(trifluoromethoxy)phenyl)oxazole
341
(3-fluoro-3′-(2-isopropyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-5-(methylsulfonyl)-4′-(3- (trifluoromethyl)-1H-pyrazol-1- yl)biphenyl-4-yl)methanol
342
2-methyl-2-(3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol- 5-yl)-4′-(3-(trifluoromethyl)-1H- pyrazol-1-yl)biphenyl-3-yl)propanenitrile
343
2-methyl-2-(3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol- 5-yl)-4′-(3-(trifluoromethyl)-1H- pyrazol-1-yl)biphenyl-3- yl)propanamide
344
4-(4-chlorophenyl)-2-methyl-5-(3′- (methylsulfonyl)-4-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-3-yl)oxazole
345
5-(4-(5-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3-yl)-2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazole
346
5-(4-(5-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3-yl)-4- (2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2 -methyloxazole
347
(4′-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(4-(2,2-(4-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3-fluoro-5- (methylsulfonyl)biphenyl-4-yl)methanol
348
4′45-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3-fluoro-3′42-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 5-(methylsulfonyl)biphenyl-4-yl)methanol
349
(3′(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3-fluoro-5- (methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
350
4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1- yl)biphenyl-3-yl)oxazole
351
4-(4-(difluoromethoxy)-3,5-difluorophenyl)- 2-methyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1- yl)biphenyl-3-yl)oxazole
352
(3′-(4-(4-(difluoromethoxy)-3,5- difluorophenyl)-2-methyloxazol-5-yl)-3-fluoro- 5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
353
4-(6-(difluoromethoxy)pyridin-3-yl)-2- methyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1- yl)biphenyl-3-yl)oxazole
354
(3′-(4-(6-(difluoromethoxy)pyridin- 3-yl)-2-methyloxaz01-5-yl)-3-fluoro- 5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
355
4-(4-chloro-3-(difluoromethoxy)phenyl)-2- methyl-5-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 3-yl)oxazole
356
(3′-(4-(4-chloro-3-(difluoromethoxy)phenyl)-2- methyloxazol-5-yl)-3-fluoro-5-(methylsulfonyl)- 4′-(3-(trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 4-yl)methanol
357
2-(1-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-5-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1H-pyrazol-3-yl)propan- 2-ol
358
2-(1-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1H-pyrazol-3-yl)propan-2-ol
359
1-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1H-pyrazole-3-carboxamide
360
1-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide
361
1-(3-(2-cyclopropyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-3′-(methylsulfonyl)[1,1′-biphenyl]- 4-yl)-1H-pyrazole-3-carboxamide
362
1-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)-1H-pyrazole-3-carbonitrile
363
(1-(3-(4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyloxazol-5-yl)-3′-(methylsu1fonyl)- [1,1′-biphenyl]-4-yl)-1H-pyrazol-3-yl)methanol
364
1-(3′-(1-amino-2-methyl-1-oxopropan- difluorobenzo[d][1,3]dioxol-5-yl)-2-methyloxazol-5- yl)-[1,1′-biphenyl]-4-yl)-1H-pyrazole-3-carboxamide
365
2-(4′-(3-(cyanomethyl)-1H-pyrazol-1-yl)-3′-(2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-[1,1′-biphenyl]-3-yl)-2-methylpropanamide
366
1-(3′-(1-amino-2-methyl-1-oxopropan-2-yl)-3-(2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazol-5- yl)-[1,1′-biphenyl]-4-yl)-N-(2,2,2-trifluoroethyl)-1H- pyrazole-3-carboxamide
367
1-(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-3′- (methylsulfonyl)[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)ethanol
368
1-(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol- 5-yl)-3′-(methylsulfonyl)[1,1′-biphenyl]- 4-yl)-1H-pyrazol-3-yl)ethanol
369
2-(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)-1H-pyrazol-3-yl)acetonitrile
370
2-(1-(3′-fluoro-4′-(hydroxymethyl)-3-(2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-5′-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)-1H-pyrazol-3-yl)acetonitrile
371
1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol- 5-yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)-N-(2,2,2-trifluoroethyl)-1H- pyrazole-3-carboxamide
372
1-(3′-fluoro-4′-(hydroxymethyl)-3-(2-methyl- 4-(4-(trifluoromethoxy)phenyl)oxazol-5-yl)- 5′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)-N- (2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide
373
2-methyl-2-(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)-1H-pyrazol-3-yl)propanenitrile
374
(1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)methylcarbamate
375
(1-(3′-fluoro-4′-(hydroxymethyl)-3-(2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazol-5-yl)-5′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1H-pyrazol- 3-yl)methylcarbamate
376
(1-(3′-(1-amino-2-methyl-1-oxopropan-2-yl)-3- (2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-[1,1′-biphenyl]-4-yl)-1H-pyrazol-3- yl)methylcarbamate
377
2-(1-(3′-fluoro-4′-(hydroxymethyl)-3-2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-5′-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)-1H-pyrazol-3-yl)-2-methylpropanenitrile
378
2-(1-(4′-(hydroxymethyl)-3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)-2-methylpropanenitrile
379
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3-fluoro-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-5- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)methanol
380
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazole
381
1-(4′-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-[1,1′-biphenyl]-3-yl)cyclopropanecarboxamide
382
(4′-(5-ethoxy-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3-fluoro-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)- 5-(methylsulfonyl)biphenyl-4-yl)methanol
383
5-(4-(difluoromethoxy)phenyl)-2-methyl-4-(4- (5-methyl-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)biphenyl-3-yl)oxazole
384
(3′-(5-(4-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(5-methyl- 3-(trifluoromethyl)-1H-pyrazol-1-yl)-5- (methylsulfonyl)biphenyl-4-yl)methanol
385
2-methyl-4-(4-(5-methyl-3-(trifluoromethyl)- 1H-pyrazol-1-yl)-3′-(methylsulfonyl)biphenyl- 3-yl)-5-(4-(trifluoromethoxy)phenyl)oxazole
386
(3-fluoro-4′-(5-methyl-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)- 5-(methylsulfonyl)biphenyl-4-yl)methanol
387
(4′-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(2-methyl-5-(4-(trifluoromethoxy)phenyl)oxazol- 4-yl)-3-(methylsulfonyl)biphenyl-4-yl)methanol
388
5-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-methyl-4- (4-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)oxazole
389
difluorobenzo[d][1,3]dioxol-5-yl)-2-methyloxazol- 4-yl)-3-fluoro-4′-(5-methyl-3-(trifluoromethyl)-1H- pyrazol-1-yl)-5-(methylsulfonyl)biphenyl-4- yl)methanol
390
(3′-(5-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-4′-(5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl)-3- (methylsulfonyl)biphenyl-4-yl)methanol
391
(3′-(5-(4-(difluoromethoxy)phenyl)-2-methyloxazol- 4-yl)-3-fluoro-4′-(3-methyl-5-(trifluoromethyl)-1H- pyrazol-1-yl)-5-(methylsulfonyl)biphenyl-4- yl)methanol
392
(3′-(5-(4-(difluoromethoxy)phenyl)-2-methyloxazol- 4-yl)-4′-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3-methylsulfonyl)biphenyl-4-yl)methanol
393
5-(4-(difluoromethoxy)phenyl)-2-methyl-4-(4-(3- methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
394
5-(6-(difluoromethoxy)pyridin-3-yl)-2-methyl-4- (3′-(methylsulfonyl)-4-(3-(trifluoromethyl)-1H-pyrazol- 1-yl)biphenyl-3-yl)oxazole
395
(3′-(5-(6-(difluoromethoxy)pyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-5-(methylsulfonyl)- 4′-(3-(trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 4-yl)methanol
396
(3′-(5-(4-chloro-3-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-5-(methylsulfonyl)- 4′-(3-(trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 4-yl)methanol
397
5-(3-chloro-4-(difluoromethoxy)phenyl)-2- methyl-4-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 3-yl)oxazole
398
(3-fluoro-3′-(2-isopropyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)- 5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
399
2-isopropyl-4-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 3-yl)-5-(4-(trifluoromethoxy)phenyl)oxazole
400
(3′-(5-(4-chlorophenyl)-2-methyloxazol-4-yl)-3- fluoro-5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
401
5-(4-chlorophenyl)-2-methyl-4-(3′-(methylsulfonyl)- 4-(3-(trifluoromethyl)-1H-pyrazol-1-yl)biphenyl-3- yl)oxazole
402
(3′-(2-cyclopropyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)-3- fluoro-5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
403
2-cyclopropyl-4-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl-3- yl)-5-(4-(trifluoromethoxy)phenyl)oxazole
404
2-(4′-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(2-methyl-5-(4-(trifluoromethoxy)phenyl)oxazol- 4-yl)biphenyl-3-yl)-2-methylpropanamide
405
(4′-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3-fluoro-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)- 5-(methylsulfonyl)biphenyl-4-yl)methanol
406
4-(4-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)biphenyl-3-yl)-2-methyl- 5-(4-(trifluoromethoxy)phenyl)oxazole
407
5-(5-fluoro-6-methoxypyridin-3-yl)-2-methyl-4- (3′-(methylsulfonyl)-4-(3-(trifluoromethyl)-1H- pyrazol-1-yl)biphenyl-3-yl)oxazole
408
(3-fluoro-3′-(5-(5-fluoro-6-methoxypyridin-3- yl)-2-methyloxazol-4-yl)-5-(methylsulfonyl)- 4′-(3-(trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 4-yl)methanol
409
5-(4-(difluoromethoxy)-3,5-difluorophenyl)-2-methyl- 4-(3′-(methylsulfonyl)-4-(3-(trifluoromethyl)-1H- pyrazol-1-yl)biphenyl-3-yl)oxazole
410
(3′-(5-(4-(difluoromethoxy)-3,5-difluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-5-(methylsulfonyl)-4′- (3-(trifluoromethyl)-1H-pyrazol-1-yl)biphenyl-4- yl)methanol
411
(4′-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-l- yl)-3′-(5-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-4-yl)-3-fluoro-5- (methylsulfonyl)biphenyl-4-yl)methanol
412
4-(4-(5-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)biphenyl-3-yl)-5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2-methyloxazole
413
(3-fluoro-3′-(2-methyl-5-(4- trifluoromethoxy)phenyl)oxazol-4- yl)-5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)biphenyl-4-yl)methanol
414
2-methyl-4-(3′-(methylsulfonyl)-4-(3- (trifluoromethyl)-1H-pyrazol-1-yl)biphenyl- 3-yl)-5-(4-(trifluoromethoxy)phenyl)oxazole
415
(4′-(5-cyclopropyl-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3-fluoro-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)-5- (methylsulfonyl)biphenyl-4-yl)methanol
416
1-(3-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol- 4-yl)-3′-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)-1H-pyrazole-3- carboxamide
417
2-(1-(3-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-3′-(methylsulfonyl)41,1′-biphenyl]- 4-yl)-1H-pyrazol-3-yl)propan-2-ol
418
1-(4′-(5-chloro-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4-yl)- [1,1′-biphenyl]-3-yl)cyclopropanecarboxamide
419
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4- (2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazole
420
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(4-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazol-5-yl)-3-fluoro-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
421
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4-(4- (difluoromethoxy)-3,5-difluorophenyl)-2- methyloxazole
422
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′(4-(4-(difluoromethoxy)-3,5-difluorophenyl)- 2-methyloxazol-5-yl)-3-fluoro-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
423
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4- (2,4-dichlorophenyl)-2-methyloxazole
424
(4′-(4-chloro-3-trifluoromethyl)-1H-pyrazol-1-yl)-3′- (4-(2,4-(4dichlorophenyl)-2-methyloxazol-5-yl)- 3-fluoro-5-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
425
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4-(6- (difluoromethoxy)pyridin-3-yl)-2-methyloxazole
426
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)-3′- (4-(6-(difluoromethoxy)pyridin-3-yl)-2-methyloxazol- 5-yl)-3-fluoro-5-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
427
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4-(2- methoxypyrimidin-5-yl)-2-methyloxazole
428
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3-fluoro-3′-(4-(2-methoxypyrimidin-5-yl)-2- methyloxazol-5-yl)-5-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)methanol
429
2-(4′-(4-chloro-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol- 5-yl)-[1,1′-biphenyl]-3-yl)-2- methylpropanenitrile
430
2-(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-[1,1′- biphenyl]-3-yl)-2-methylpropanamide
431
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4-(2- chloro-4-(difluoromethoxy)phenyl)-2-methyloxazole
432
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(4-(2-chloro-4-(difluoromethoxy)phenyl)-2- methyloxazol-5-yl)-3-fluoro-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
433
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]-3-yl)-4-(4- (difluoromethoxy)-3-fluorophenyl)-2-methyloxazole
434
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(4-(4-(difluoromethoxy)-3-fluorophenyl)-2- methyloxazol-5-yl)-3-fluoro-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
435
4-(4-(difluoromethoxy)phenyl)-2-methyl-5-(3′- (methylsulfonyl)-4-(3-(trifluoromethyl)-1H-pyrazol- 1-yl)-[1,1′-biphenyl]-3-yl)oxazole
436
(3′-(4-(4-(difluoromethoxy)phenyl)-2-methyloxazol-5- yl)-3-fluoro-5-(methylsulfonyl)-4′-(3-(trifluoromethyl)- 1H-pyrazol-1-yl)-[1,1′-biphenyl]-4-yl)methanol
437
5-(4-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3′-(methylsulfonyl)-[1,1-biphenyl]-3-yl)-2-methyl- 4-(4-(trifluoromethyl)phenyl)oxazole
438
(4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)- 3-fluoro- 3′-(2-methyl-4-(4-(trifluoromethyl)phenyl)oxazol- 5-yl)-5-(methylsulfonyl)-[1,l′-biphenyl]-4-yl)methanol
439
(3-fluoro-4′-(4-methyl-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)-5- (methylsulfonyl)-[1,l′-biphenyl]-4-yl)methanol
440
2-methyl-5-(4-(4-methyl-3-(trifluoromethyl)-1H- pyrazol-1-yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]- 3-yl)-4-(4-(trifluoromethoxy)phenyl)oxazole
441
2-(4-chloro-1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 3′-(methylsulfonyl)41,1′-biphenyl]-4-yl)- 1H-pyrazol-3-yl)propan-2-ol
442
5-(4-(3-(1,1-difluoroethyl)-1H-pyrazol-1-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-3-yl)-2-methyl-4- (4-(trifluoromethoxy)phenyl)oxazole
443
2-(4-chloro-1-(3′-fluoro-4′-(hydroxymethyl)-3-(2- methyl-4-(4-(trifluoromethoxy)phenyl)oxazol-5- yl)-5′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)-1H- pyrazol-3-yl)propan-2-ol
444
4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol-1- yl)-N-methyl-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-[1,1′-biphenyl]-3-sulfonamide
445
4′-(4-chloro-3-(trifluoromethyl)-1H-pyrazol- 1-yl)-3′-(4-(2-methoxypyrimidin-5-yl)-2- methyloxazol-5-yl)-N-methyl-[1,1′- biphenyl]-3-sulfonamide
446
3-cyclopropyl-1-(3′-fluoro-4′-(hydroxymethyl)-3- (2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-5′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)- 1H-pyrazole-4-carbonitrile
447
3-cyclopropyl-1-(3-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5-yl)- 3′-(methylsulfonyl)41,1′-biphenyl]-4-yl)- 1H-pyrazole-4-carbonitrile
448
3-cyclopropyl-1-(3′-fluoro-4′-(hydroxymethyl)- 3-(2-methyl-4-(4-(trifluoromethoxy)phenyl)oxazol- 5-yl)-5′-(methylsulfonyl)41,1′-biphenyl]-4-yl)- 1H-pyrazole-4-carboxamide.
12. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, and one or more pharmaceutically acceptable carriers.
13. A method of therapeutically treating a disease or disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein the disease or disorder is atherosclerosis or diabetes.
14. The method of claim 13 , wherein the disease or disorder is atherosclerosis.
15. The method of claim 13 , wherein the disease or disorder is diabetes.
16. A composition comprising a compound of claim 11 , or a pharmaceutically acceptable salt or solvate thereof, and one or more pharmaceutically acceptable carriers.
17. A method of therapeutically treating a disease or disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 11 , or a pharmaceutically acceptable salt or solvate thereof, wherein the disease or disorder is atherosclerosis or diabetes.
18. The method of claim 17 , wherein the disease or disorder is atherosclerosis.
19. The method of claim 17 , wherein the disease or disorder is diabetes.