The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.
1. A compound of formula
or a pharmaceutically acceptable salt thereof, wherein
L is a bond, —[C(R 1 ) 2 ] m —, -cyclopropyl-, or —CO—;
m is 1 or 2;
n is 0, 1, 2, 3, or 4;
R 1 is independently selected from H, C 1-3 alkyl, C 1-3 haloalkyl, —OH, or halo;
A is phenyl, cyclohexyl, a 5 or 6 membered heterocyclyl, or a 5 or 6 membered heteroaryl, wherein the phenyl is optionally fused to a 5 or 6 membered heterocyclyl or 5 or 6 membered heteroaryl,
wherein A is optionally substituted with 1, 2, or 3 R A groups, wherein
each R A is independently R A1 , —C 1 -C 6 alkyl-R A1 , C 1 -C 6 alkyl, C1-C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, or heterocyclyl wherein the cycloalkyl and heterocyclyl are each optionally substituted with 1, 2, 3, or 4 groups that are independently R A1 , C 1 -C 6 alkyl, or —C 1 -C 6 alkyl-R A1 , wherein
each R A1 is independently halogen, cyano, nitro, —OR, —NR 2 , —SR, —C(O)R, or —C(O)OR;
alternatively, 2R A on adjacent carbons can join to form a —O—CH 2 —O—, —O—CH 2 —CH 2 —, —O—CH 2 —CH 2 —O—, —CH 2 —CH 2 —CH 2 —, or —O—CF 2 —O—;
ring C is a 5 membered heterocyclic ring selected from triazolyl, imidazolyl, pyrrazolyl, oxazolyl; wherein when ring C is pyrrazolyl, imidazolyl, or oxazolyl, then ring C is optionally substituted with C 1-4 alkyl, C 2-3 alkenyl, C 1-3 haloalkyl, C 3-6 cycloalkyl, —CF 3 , —C 1-4 alkyl-OH, —C 1-4 alkyl-O—C 1-3 alkyl, —C 1-3 alkyl-NR 2 ; —C 1-3 alkyl-CO 2 H, —C 1-3 alkyl-NHSO 2 —C 1-3 alkyl, —NH—C 1-3 alkyl-OR, —C 1-3 alkyl-pyrrolidinyl;
R B1 is hydrogen, C 1-3 alkyl, halo, or C 1-3 haloalkyl;
R B2 is hydrogen or halo;
R B3 is hydrogen, C 1-3 alkyl, halo, —CN, C 1-3 haloalkyl, —C(O)—C 1-3 alkyl, —CO—NH 2 , —CO—N(R) 2 , or —C 1-3 alkyl-OH,
each R D1 and R D2 are independently R D3 , C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R D3 , C 1 -C 6 haloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, or heterocyclyl, wherein the cycloalkyl or heterocyclyl are each optionally substituted with 1, 2, 3, or 4 groups that are independently R D3 , C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or —C 1 -C 6 alkyl-R D3 , wherein
each R D3 is independently halogen,
cyano, —OR, —NR 2 , —SR, —C(O)R, —C(O)OR, —C(O)NR 2 , —S(O)R, —S(O) 2 R, —S(O)NR 2 , —S(O) 2 NR 2 , —OC(O)R, —OC(O)OR, —OC(O)NR 2 , —N(R)C(O)R, —N(R)C(O)OR, —N(R)C(O)NR 2 , —N(R)S(O) 2 R, —N(R)S(O) 2 OR, —N(R)S(O) 2 NR 2 , or —S(O) 2 N(R)C(O)NR 2 ; and
R C is hydrogen, halogen, C 1 -C 6 alkyl, cyano, or nitro;
each R group is independently hydrogen, C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R 2 , C 1 -C 6 haloalkyl, —C 1 -C 6 haloalkyl-R 2 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 3 -C 8 cycloalkyl, wherein each R 2 is independently cyano, —OR 3 , —N(R 3 ) 2 , —N(R 3 )S(O) 2 R 3 , —N(R 3 )S(O) 2 OR 3 , or —N(R 3 )S(O) 2 N(R 3 ) 2 , wherein each R 3 is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl.
2. A compound of the formula I,
or pharmaceutically acceptable salt thereof, wherein
L is a bond, —[C(R 1 ) 2 ] m —, -cyclopropyl-, or —CO—;
m is 1 or 2;
R 1 is independently selected from H, C 1-3 alkyl, —OH, or halo;
A is phenyl, cyclohexyl, naphthalenyl, benzofuranyl, 2,3-dihydro-1H-indenyl, 1H-indolyl, pyridyl, pyrazinyl, pyrimidinyl, dihydrobenzofuranyl, pyridin-2(1H)-one, imidazo[1,2-a]pyridinyl, or piperidinyl, wherein A is optionally substituted with 1, 2, or 3 R A groups; wherein
each R A is independently halo, —CN, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —O—R, —NR 2 , —O—C 1-6 alkyl, —O—C 1-6 alkyl-C 3-6 cycloalkyl, —S—R, —CO—R, —C(O)O—R, —C 1-6 alkyl-CO—NR 2 , pyrrolidinone, or pyrrolidinyl;
alternatively, 2R A on adjacent carbons can join to form a —O—CH 2 —O—, —O—CH 2 —CH 2 —, —O—CH 2 —CH 2 —O—, or —O—CF 2 —O—;
ring C is a 5 membered heterocyclic ring selected from triazolyl, imidazolyl, pyrrazolyl, and oxazolyl; wherein when ring C is pyrrazolyl, imidazolyl, or oxazolyl, then ring C is optionally substituted with C 1-4 alkyl, C 2-3 alkenyl, C 1-3 haloalkyl, C 3-6 cycloalkyl, —CF 3 —, —C 1-4 alkyl-OH, —C 1-4 alkyl-O—C 1-3 alkyl, —C 1-3 alkyl-NR 2 ; —C 1-3 alkyl-CO 2 H, —C 1-3 alkyl-NHSO 2 —C 1-3 alkyl, —NH—C 1-3 alkyl-OR, or —C 1-3 alkyl-pyrrolidinyl;
R B1 is hydrogen, C 1-3 alkyl, halo, or C 1-3 haloalkyl;
R B2 is hydrogen or halo;
R B3 is hydrogen, C 1-3 alkyl, halo, —CN, C 1-4 haloalkyl, cyclopropyl, —CO—NH 2 , —CO—NR 2 , or —C 1-3 alkyl-OH,
R C is hydrogen, halogen, or cyano;
n is 0, 1, 2, 3, or 4; and
R D1 is —SO 2 —C 1-6 alkyl, —SO 2 —C 1-6 haloalkyl, —SO 2 —C 3-6 cycloalkyl, —SO 2 —C 1-6 alkyl-OH, —SO 2 —C 1-6 alkyl-O—C 1-6 alkyl, —C(Me) 2 -COOH, —C(Me) 2 -CONR 2 , -cyclopropyl-CONR 2 , —SO 2 NR 2 , —SO 2 NR—C 1-6 alkyl-OH, —SO 2 -pyrrolidinyl, or —CONR 2
R D2 is independently —C 1-6 haloalkyl-C 1-6 alkyl-OH, halo, —C 1-6 alkyl-O—C 1-6 alkyl, C 1-6 alkyl-NHSO 2 —C 1-6 alkyl, C 1-6 haloalkyl, or —O—C 1-6 alkyl-O—C 1-6 haloalkyl, each R group is independently hydrogen, C 1 -C 6 alkyl, —C 1 -C 6 alkyl-R 2 , C 1 -C 6 haloalkyl, —C 1 -C 6 haloalkyl-R 2 , C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl; each R 2 is independently —OR 3 , wherein each R 3 is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl.
3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
R B1 is H, alkyl, or haloalkyl;
R B2 is H, alkyl, or halo; and
R C is hydrogen or halo.
4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
L is a bond; and
A is phenyl, pyridyl or pyrimidinyl.
5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
ring C is a 5 membered heterocyclic ring selected from triazolyl, imidazolyl, pyrrazolyl, and oxazolyl; wherein when ring C is pyrrazolyl, imidazolyl, or oxazolyl, then ring C is optionally substituted with C 1-4 alkyl, C 2-3 alkenyl, C 1-3 haloalkyl, C 3-6 cycloalkyl, —CF 3 , —C 1-4 alkyl-OH, —C 1-4 alkyl-O—C 1-3 alkyl, —C 1-3 alkyl-NR 2 ; —C 1-3 alkyl-CO 2 H, —C 1-3 alkyl-NHSO 2 —C 1-3 alkyl, —NH—C 1-3 alkyl-OR, or —C 1-3 alkyl-pyrrolidinyl.
6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
R D1 is —SO 2 -alkyl, SO 2 NR 2 , —C(Me) 2 -CONH 2 , or
and
R D2 is —C 1-6 alkyl-OH or halo.
7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
ring C is a 5 membered heterocyclic ring selected from triazolyl, imidazolyl, pyrrazolyl, oxazolyl; wherein when ring C is pyrrazolyl, imidazolyl, or oxazolyl, then ring C is optionally substituted with C 1-4 alkyl, —CF 3 , cyclopropyl, —C 1-3 alkyl-N(CH 3 ) 2 ; —C 1-4 alkyl-OH, or —C 1-4 alkyl-O—C 1-3 alkyl.
8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
ring C is a 5 membered heterocyclic ring selected from triazolyl, imidazolyl, pyrrazolyl, oxazolyl; wherein when ring C is pyrrazolyl, imidazolyl, or oxazolyl, then ring C is optionally substituted with —CH 3 , —CF 3 , or cyclopropyl.
9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
R D1 is —SO 2 —CH 3 , or —SO 2 NR 2 .
10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein
R D1 is —SO 2 —CH 3 .
11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is
12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is
13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) is
14. A compound selected from Examples 1 to 647 listed below, or a pharmaceutically acceptable salt thereof
Ex #
Structure
Name
1
{4′-[5-chloro-2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]-3- fluoro-5-(methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
2
Preparation of 5-(4-chlorophenyl)-1- {4-[2-chloro-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-1H- 1,2,3-triazole
3
2-methyl-1-[3′-(methylsulfonyl)-3-(5- {4-[(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl]-N- (2,2,2-trifluoroethyl)-1H-imidazole-4- carboxamide
4
5-[4-(fluoromethyl)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
5
5-[4-(difluoromethyl)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
6
1-(4-(4-(difluoromethyl)-2-methyl-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazole
7
1-(5-chloro-3′-(methylsulfonyl)-4-(4- (trifluoromethyl)-1H-imidazol-1- yl)biphenyl-3-yl)-5-(4-chlorophenyl)- 1H-1,2,3-triazole
8
5-(2,4-dichlorophenyl)-1-{5-fluoro-3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
9
(3-fluoro-3′-{5-[1-(4- methylphenyl)ethyl]-1H-1,2,3-triazol- 1-yl}-5-(methylsulfonyl)-4′-[2-methyl- 4-(trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl)methanol
10
(4-chlorophenyl)(1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)methanone
11
1-(4-chlorophenyl)-2,2,2-trifluoro-1- (1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)ethanol
12
5-[(4-chlorophenyl)(difluoro)methyl]- 1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
13
5-(4-chlorophenyl)-1-{3′- (methylsulfonyl)-4-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
18
{3-chloro-3′-[5-(2,4-dichlorophenyl)- 1H-1,2,3-triazol-1-yl]-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
19
5-(2,4-dichlorophenyl)-1-{3′- (methylsulfonyl)-4-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
20
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{3-methyl-4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
21
{3-chloro-3′-[5-(2,2-difluoro-1,3- benzodioxol-5-yl)-1H-1,2,3-triazol-1- yl]-5-(methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
22
N,N-dimethyl-4-(1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)aniline
23
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4-[(1,1,2,2- tetrafluoroethyl)oxy]phenyl}-1H- 1,2,3-triazole
24
5-[2-methyl-4-(methyloxy)phenyl]-1- {3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
25
1-{3′-(methylsulfonyl)-4-[2-methyl-4- trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-[3- (trifluoromethyl)phenyl]-1H-1,2,3- triazole
26
5-[4-(methyloxy)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
27
2-methyl-2-{4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- yl}propanamide
28
5-(4-fluoro-3-methylphenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
29
5-(1,3-benzodioxol-5-yl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
30
5-[4-(butyloxy)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
31
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4-[(2,2,2- trifluoroethyl)oxy]phenyl}-1H-1,2,3- triazole
32
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)thio]phenyl}-1H- 1,2,3-triazole
33
5-(3-chloro-4-fluorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
34
5-(3,4-difluorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
35
5-{4-chloro-3- [(trifluoromethyl)oxy]phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
36
1-[4-(1-{3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-1H- 1,2,3-triazol-5-yl)phenyl]ethanone
37
5-{3-[(difluoromethyl)oxy]phenyl}-1- {3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
39
5-(4-chloro-2-fluorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
40
5-(2,4-difluorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
41
2-chloro-5-(1-{3′-(methylsulfonyl)-4- [2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-1H- 1,2,3-triazol-5-yl)benzonitrile
42
5-{3-[(difluoromethyl)oxy]-4- (methyloxy)phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
43
5-(4-fluorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
44
4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
45
5-(1-{3′-(methylsulfonyl)-4-[2-methyl- 4-(trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)-1H-indole
46
5-{4-fluoro-3- [(trifluoromethyl)oxy]phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
47
4-(1-{3′-(methylsulfonyl)-4-[2-methyl- 4-(trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)benzonitrile
48
{3-fluoro-3′-[5-(4-methylphenyl)-1H- 1,2,3-triazol-1-yl]-5-(methylsulfonyl)- 4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
49
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
50
5-(4-methylphenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
51
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-(4-pyrrolidin-1- ylphenyl)-1H-1,2,3-triazole
52
{3′-[5-(2,2-difluoro-1,3-benzodioxol- 5-yl)-1H-1,2,3-triazol-1-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
53
5-{3-chloro-4- [(trifluoromethyl)oxy]phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
54
5-{3-fluoro-4- [(trifluoromethyl)oxy]phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
55
1-{4-[5-chloro-2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(methylsulfonyl)biphenyl-3-yl}-5- {4-[(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
56
{3-fluoro-3′-(5-{3-fluoro-4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)-5-(methylsulfonyl)- 4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
57
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{2-methyl-4- (trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
58
{3′-[5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
59
1-{4-[5-chloro-2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(methylsulfonyl)biphenyl-3-yl}-5- (2,4-dichlorophenyl)-1H-1,2,3-triazole
60
{3-chloro-4′-[5-chloro-2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]-5- (methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
61
5-{2-fluoro-4- [(trifluoromethyl)oxy]phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
62
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-[4- (trifluoromethyl)phenyl]-1H-1,2,3- triazole
63
{3-chloro-3′-[5-(4-methylphenyl)-1H- 1,2,3-triazol-1-yl]-5-(methylsulfonyl)- 4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
64
5-[4-chloro-3- (trifluoromethyl)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
65
5-{4-[(difluoromethyl)oxy]phenyl}-1- {3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
66
5-(4-chlorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
67
{3′-[5-(2,4-dichlorophenyl)-1H-1,2,3- triazol-1-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
68
5-{2-chloro-4- [(trifluoromethyl)oxy]phenyl}-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
69
5-(4-chloro-3-fluorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
70
{3-chloro-3′-[5-(4-chlorophenyl)-1H- 1,2,3-triazol-1-yl]-5-(methylsulfonyl)- 4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
71
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-(3,4,5- trifluorophenyl)-1H-1,2,3-triazole
72
5-[4-(1-methylethyl)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
73
5-(2,2-difluoro-1,3-benzodioxol-5-yl)- 1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
74
5-[4-(methyloxy)-3- (trifluoromethyl)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
75
5-(3,4-dichlorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
76
5-(2,4-dichlorophenyl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
77
5-fluoro-2-(1-{3′-(methylsulfonyl)-4- [2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-1H- 1,2,3-triazol-5-yl)pyridine
78
{3′-(5-{3-chloro-4- (trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
79
{3-chloro-3′-[5-(3,4-dichlorophenyl)- 1H-1,2,3-triazol-1-yl]-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
80
5-(1-{3′-(methylsulfonyl)-4-[2-methyl- 4-(trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)-2-(trifluoromethyl)pyridine
81
{3′-[5-(3,4-dichlorophenyl)-1H-1,2,3- triazol-1-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
82
methyl 4-(1-{3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-1H- 1,2,3-triazol-5-yl)benzoate
83
1-[4-(2,4-dimethyl-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl]-5- {4-[(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
84
[4′-(2,4-dimethyl-1H-imidazol-1-yl)-3- fluoro-5-(methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
85
1-{4′-[(ethyloxy)methyl]-3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
86
5-(1-benzofuran-5-yl)-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
87
N-{[3-(methylsulfonyl)-4′-[2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl]- 3′-(5-{4- [(trifluoromethyl)oxy]pheny}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methyl}methanesulfonamide
88
1-{3′-fluoro-4′-[(methyloxy)methyl]- 5′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
89
1-{4′-[(methyloxy)methyl]-3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
90
[3-(methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
91
1-{3′-fluoro-5′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
92
[3-(ethylsulfonyl)-5-fluoro-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
93
5-[2,4-bis(methyloxy)phenyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
94
1-{4′-(methyloxy)-3′-(methylsulfonyl)- 4-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
95
2-methyl-2-{4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- yl}propanoic acid
98
1-{3′-[(1-methylethyl)sulfonyl]-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
99
1-{6-fluoro-3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- (trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
100
5-(4-chlorophenyl)-1-{6-fluoro-3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
101
5-(2,4-dichlorophenyl)-1-{6-fluoro-3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
102
{2′-chloro-3′-[5-(4-chlorophenyl)-1H- 1,2,3-triazol-1-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
103
{2′-chloro-3′-[5-(2,4-dichlorophenyl)- 1H-1,2,3-triazol-1-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
105
N,N-dimethyl-3′-{5-[1-(4- methylphenyl)ethyl]-1H-1,2,3-triazol- 1-yl}-4′-[2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl]biphenyl-3- sulfonamide
106
(3′-{5-[1-(4- chlorophenyl)cyclopropyl]-1H-1,2,3- triazol-1-yl}-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl)methanol;
107
1-{3′-(ethylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-[1-(4- methylphenyl)ethyl]-1H-1,2,3-triazole
108
5-[1-(4-chlorophenyl)ethyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
109
(3′-{5-[1-(4-chlorophenyl)ethyl]-1H- 1,2,3-triazol-1-yl}-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl)methanol
110
(3-chloro-3′-{5-[1-(4- methylphenyl)ethyl]-1H-1,2,3-triazol- 1-yl}-5-(methylsulfonyl)-4′-[2-methyl- 4-(trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl)methanol
111
5-[1-(4-methylphenyl)ethyl]-1-{3′- methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
112
5-[1-(4-chlorophenyl)cyclopropyl]-1- {3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
113
(3′-{5-[(4-chlorophenyl)methyl]-1H- 1,2,3-triazol-1-yl}-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl)methanol
114
2-(3′-{5-[(3-chlorophenyl)methyl]-1H- 1,2,3-triazol-1-yl}-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl)-2- methylpropanamide
115
5-[(3,4-dichlorophenyl)methyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
116
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-({3- [(trifluoromethyl)oxy]phenyl}methyl)- 1H-1,2,3-triazole
117
(3-chloro-3′-{5-[(3- chlorophenyl)methyl]-1H-1,2,3- triazol-1-yl}-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl)methanol
118
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-({4- [(trifluoromethyl)oxy]phenyl}methyl)- 1H-1,2,3-triazole
119
2-(3′-{5-[(4-chlorophenyl)methyl]-1H- 1,2,3-triazol-1-yl}-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl)-2- methylpropanamide
120
(3′-{5-[(3-chlorophenyl)methyl]-1H- 1,2,3-triazol-1-yl}-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl)methanol
121
5-[(3-chlorophenyl)methyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
122
(3-chloro-3′-{5-[(4- chlorophenyl)methyl]-1H-1,2,3- triazol-1-yl}-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl)methanol
123
1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-({2- [(trifluoromethyl)oxy]phenyl}methyl)- 1H-1,2,3-triazole
124
5-[(4-fluorophenyl)methyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
125
5-[(4-chlorophenyl)methyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
126
5-[(4-methylphenyl)methyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
127
5-[(4-methylcyclohexyl)methyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
129
5-[2-(4-chlorophenyl)ethyl]-1-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
130
3′-{5-[1-(4-chlorophenyl)ethyl]-1H- 1,2,3-triazol-1-yl}-4′-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-N-methylbiphenyl-3- sulfonamide
131
5-[1-(4-chlorophenyl)ethyl]-1-{4-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-3′- (ethylsulfonyl)biphenyl-3-yl}-1H- 1,2,3-triazole
132
3′-{5-[1-(4-chlorophenyl)ethyl]-1H- 1,2,3-triazol-1-yl}-4′-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-N,N-dimethylbiphenyl- 3-sulfonamide
133
5-[1-(4-chlorophenyl)ethyl]-1-{4-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-1H- 1,2,3-triazole
134
[3′-{5-[1-(4-chlorophenyl)ethyl]-1H- 1,2,3-triazol-1-yl}-4′-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-3-fluoro-5- (methylsulfonyl)biphenyl-4- yl]methanol
135
2-methyl-2-{4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(5-{[4- (trifluoromethyl)phenyl]carbonyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- yl}propanamide
136
(1-{3′-fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)[3-(trifluoromethyl)phenyl] methanone
137
(1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)[3-(trifluoromethyl)phenyl] methanone
138
(1-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)[4- (trifluoromethyl)phenyl]methanone
139
2-(3′-{5-[(4-chlorophenyl)carbonyl]- 1H-1,2,3-triazol-1-yl}-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl)-2- methylpropanamide
140
(4-chlorophenyl)(1-{3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- 4-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-1H- 1,2,3-triazol-5-yl)methanone
141
(1-{3′-fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazol-5- yl)[4-(trifluoromethyl)phenyl] methanone
142
5-[(4-chlorophenyl)(difluoro)methyl]- 1-{3′-(ethylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
143
1-{4-[2-chloro-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5- (2,4-dichlorophenyl)-1H-1,2,3-triazole
144
{3′-[5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl]-4′-[2-chloro-4- (trifluoromethyl)-1H-imidazol-1-yl]-3- fluoro-5-(methylsulfonyl)biphenyl-4- yl}methanol
145
{4′-[2-chloro-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-[5-(2,4- dichlorophenyl)-1H-1,2,3-triazol-1- yl]-3-fluoro-5- methylsulfonyl)biphenyl-4- yl}methanol
146
1-{4-[2-chloro-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
147
[4′-(4-chloro-2-methyl-1H-imidazol-1- yl)-3-fluoro-5-(methylsulfonyl)-3′-(5- {4-[(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
148
[4′-(4-chloro-2-methyl-1H-imidazol-1- yl)-3′-[5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl]-3-fluoro-5- (methylsulfonyl)biphenyl-4- yl]methanol
149
1-[4-(4-chloro-2-methyl-1H-imidazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3- yl]-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
150
1-[4-(4-chloro-2-methyl-1H-imidazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3- yl]-5-(4-chlorophenyl)-1H-1,2,3- triazole
151
1-[4-(4,5-dichloro-2-methyl-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl]-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
152
N-(1,1-dimethylethyl)-2-methyl-1-[3′- methylsulfonyl)-3-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4-yl]-1H- imidazole-4-carboxamide
154
4′-[4-(difluoromethyl)-2-methyl-1H- imidazol-1-yl]-N-methyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
155
4′-[4-(difluoromethyl)-2-methyl-1H- imidazol-1-yl]-N,N-dimethyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
156
2-{4′-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3-yl}-2- methylpropanamide
157
1-{4-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (ethylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
158
{3-chloro-4′-[4-(difluoromethyl)-2- methyl-1H-imidazol-1-yl]-5- (methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
159
{4′-[4-(difluoromethyl)-2-methyl-1H- imidazol-1-yl]-3-(methylsulfonyl)-3′- (5-{4-[(trifluoromethyl)oxy]phenyl}- 1H-1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
162
5-(4-chlorophenyl)-1-{4-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-1H- 1,2,3-triazole
163
5-(2,4-dichlorophenyl)-1-{4-[4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl]-3′- methylsulfonyl)biphenyl-3-yl}-1H- 1,2,3-triazole
164
1-{4-[4-(1,1-difluoro-2-methylpropyl)- 2-methyl-1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
165
1-{4-[4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
166
1-{4-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-[4- (methyloxy)phenyl]-1H-1,2,3-triazole
167
5-(2,2-difluoro-1,3-benzodioxol-5-yl)- 1-{4-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-1H- 1,2,3-triazole
168
1-{4-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-(4- methylphenyl)-1H-1,2,3-triazole
169
1-{4-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-{3- fluoro-4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
170
1-{4-[4-(difluoromethyl)-1H-imidazol- 1-yl]-3′-(methylsulfonyl)biphenyl-3- yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
171
1-{4-[4-(difluoromethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5- phenyl-1H-1,2,3-triazole
172
1-{4-[5-chloro-4-(difluoromethyl)-2- methyl-1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
173
{4′-[5-chloro-4-(difluoromethyl)-2- methyl-1H-imidazol-1-yl]-3-fluoro-5- (methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
174
{4′-[4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl]-3-fluoro-5- (methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
175
4′-[4-(1,1-difluoroethyl)-2-methyl-1H- imidazol-1-yl]-N-methyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
176
5-(4-chlorophenyl)-1-{4-[4-(1,1- difluoroethyl)-2-methyl-1H-imidazol- 1-yl]-3′-(methylsulfonyl)biphenyl-3- yl}-1H-1,2,3-triazole
177
1-{4-[4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (ethylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
178
{4′-[4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl]-3-(methylsulfonyl)- 3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
179
1-{4-[4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl]-3′-fluoro-4′- [(methyloxy)methyl]-5′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
180
5-(2,4-dichlorophenyl)-1-{4-[4-(1,1- difluoroethyl)-2-methyl-1H-imidazol- 1-yl]-3′-(methylsulfonyl)biphenyl-3- yl}-1H-1,2,3-triazole
181
4′-[4-(1,1-difluoroethyl)-2-methyl-1H- imidazol-1-yl]-N,N-dimethyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
182
4′-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-N,N-dimethyl-3′-(5- {4-[(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
183
4′-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
184
1-{4-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
185
4′-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-N-methyl-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
186
{4′-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-3-fluoro-5- (methylsulfonyl)-3′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl}methanol
187
5-(4-chlorophenyl)-1-{5-fluoro-3′- (methylsulfonyl)-4-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
188
1-{5-fluoro-3′-(methylsulfonyl)-4-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
189
[3,3′-difluoro-5-(methylsulfonyl)-4′-[4- (trifluoromethyl)-1H-imidazol-1-yl]- 5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
190
{3′-[5-(2,4-dichlorophenyl)-1H-1,2,3- triazol-1-yl]-3,5′-difluoro-5- (methylsulfonyl)-4′-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
191
5-(2,4-dichlorophenyl)-1-{5-fluoro-3′- (methylsulfonyl)-4-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
192
1-{5-chloro-3′-(methylsulfonyl)-4-[4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
193
[3′-chloro-3-fluoro-5-(methylsulfonyl)- 4′-[4-(trifluoromethyl)-1H-imidazol-1- yl]-5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
195
1-{5-chloro-3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
196
[3′-chloro-3-fluoro-5-(methylsulfonyl)- 4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
197
[3-chloro-3′-fluoro-5-(methylsulfonyl)- 4′-[2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
198
{3′-[5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl]-3,5′-difluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
199
1-{5-fluoro-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(pyrrolidin-1-ylsulfonyl)biphenyl-3- yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
200
{3′-[5-(2,4-dichlorophenyl)-1H-1,2,3- triazol-1-yl]-3,5′-difluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
201
1-{5-fluoro-3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
202
[3,3′-difluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
203
[3′-fluoro-3-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-4- yl]methanol
204
5-(4-chlorophenyl)-1-{5-fluoro-3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
205
3′-fluoro-N-methyl-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
206
1-{3′,5-difluoro-4′- [(methyloxy)methyl]-5′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
207
5-(4-chlorophenyl)-1-{3′,5-difluoro-4′- [(methyloxy)methyl]-5′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-1,2,3-triazole
208
3′-fluoro-N-(2-hydroxyethyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-5′-(5-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-1-yl)biphenyl-3- sulfonamide
209
3′-[5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl]-5′-fluoro-N-methyl-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-sulfonamide
210
{3′-[5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl]-5′-fluoro-3- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
211
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4- yl)methanol
212
(3-chloro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4- yl)methanol
213
N-methyl-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(5-(4-(trifluoromethoxy)phenyl)- 1H-1,2,3-triazol-1-yl)-[1,1′-biphenyl]- 3-sulfonamide
214
N,N-dimethyl-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(5-(4-(trifluoromethoxy)phenyl)- 1H-1,2,3-triazol-1-yl)-[1,1′-biphenyl]- 3-sulfonamide
215
1-(3′-(ethylsulfonyl)-4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazole
216
(3′-(5-(benzofuran-5-yl)-1H-1,2,3- triazol-1-yl)-3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
219
5-(2-chlorobenzyl)-1-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-1H-1,2,3-triazole
220
(4′-(4-(difluoromethyl)-2-methyl-1H- imidazol-1-yl)-3-fluoro-5- (methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4- yl)methanol
221
(4′-(4-(1,1-difluoro-2-methylpropyl)-2- methyl-1H-imidazol-1-yl)-3-fluoro-5- (methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4- yl)methanol
222
5-(2-(4-chlorophenyl)propan-2-yl)-1- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-1H-1,2,3-triazole
223
(3′-(5-(2-(4-chlorophenyl)propan-2- yl)-1H-1,2,3-triazol-1-yl)-3-fluoro-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
224
5-(1-(4-chlorophenyl)-1-fluoroethyl)- 1-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-1H-1,2,3-triazole
225
5-(4-chlorophenyl)-1-(4-(2- (difluoromethyl)-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-1H-1,2,3-triazole
226
1-(4-(2-(difluoromethyl)-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4-(trifluoromethoxy)phenyl)- 1H-1,2,3-triazole
227
1-(4-(2-ethyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazole
228
5-(4-chlorophenyl)-1-(4-(4- cyclopropyl-2-methyl-1H-imidazol-1- yl)-3′-(methylsulfonyl)-[1,1′-biphenyl]- 3-yl)-1H-1,2,3-triazole
229
1-(4-(4-cyclopropyl-2-methyl-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazole
230
5-(4-chlorophenyl)-1-(4-(4- (difluoromethyl)-2,5-dimethyl-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-1H-1,2,3-triazole
231
(3′-(5-(4-chlorophenyl)-1H-1,2,3- triazol-1-yl)-4′-(4-(difluoromethyl)- 2,5-dimethyl-1H-imidazol-1-yl)-3- fluoro-5-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)methanol
232
1-(4-(4-(difluoromethyl)-2,5-dimethyl- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazole
233
(4′-(4-(difluoromethyl)-2,5-dimethyl- 1H-imidazol-1-yl)-3-fluoro-5- methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4- yl)methanol
234
2-methyl-1-(2-methyl-1-(3′- (methylsulfonyl)-3-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H- imidazol-4-yl)propan-1-one
235
1-(1-(3′-fluoro-4′-(hydroxymethyl)-5′- (methylsulfonyl)-3-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4-yl)-2- methyl-1H-imidazol-4-yl)-2- methylpropan-1-one
236
2-(4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3-(methylsulfonyl)- 3′-(5-(4-(trifluoromethoxy)phenyl)- 1H-1,2,3-triazol-1-yl)-[1,1′-biphenyl]- 4-yl)ethanol
237
2-(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-3′-(5-(4- (trifluoromethoxy)phenyl)-1H-1,2,3- triazol-1-yl)-[1,1′-biphenyl]-4- yl)ethanol
238
1-(3′-((methoxymethyl)sulfonyl)-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-[1,1′-biphenyl]-3-yl)-5- (4-(trifluoromethoxy)phenyl)-1H- 1,2,3-triazole
241
2-methyl-2-{4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(1-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-5-yl)biphenyl-3- yl}propanamide
242
5-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazole
243
5-{4-[5-chloro-2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(methylsulfonyl)biphenyl-3-yl}-1- (4-chlorophenyl)-1H-1,2,3-triazole
244
[3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-(1-{4- [(trifluoromethyl)oxy]phenyl}-1H- 1,2,3-triazol-5-yl)biphenyl-4- yl]methanol
245
1-(4-chlorobenzyl)-5-(4-(4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-1H-1,2,3-triazole
246
3′-(1-(4-chlorobenzyl)-1H-1,2,3- triazol-5-yl)-4′-(4-(difluoromethyl)-2- methyl-1H-imidazol-1-yl)-N-methyl- [1,1′-biphenyl]-3-sulfonamide
247
1-(4-chlorobenzyl)-5-(4-(4- (difluoromethyl)-2-methyl-1H- imidazol-1-yl)-3′-(ethylsulfonyl)-[1,1′- biphenyl]-3-yl)-1H-1,2,3-triazole
248
(3′-(1-(4-chlorobenzyl)-1H-1,2,3- triazol-5-yl)-4′-(4-(difluoromethyl)-2- methyl-1H-imidazol-1-yl)-3-fluoro-5- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
286
1-(4-chlorophenyl)-5-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1H-pyrazole
287
(3′-(1-(4-(difluoromethoxy)phenyl)-3- methyl-1H-pyrazol-5-yl)-3-fluoro-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
288
{3′-[1-(4-chlorophenyl)-1H-pyrazol-5- yl]-3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
289
5-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1-{4- [(trifluoromethyl)oxy]phenyl}-1H- pyrazole
290
{3′-[1-(4-chlorophenyl)-3-methyl-1H- pyrazol-5-yl}-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
291
3-methyl-5-{3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-1-{4- [(trifluoromethyl)oxy]phenyl}-1H- pyrazole
292
[3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-(1-{4- [(trifluoromethyl)oxy]phenyl}-1H- pyrazol-5-yl)biphenyl-4-yl]methanol
293
1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-5-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)-1H- pyrazole
294
(3′-(1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- pyrazol-5-yl)-3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
295
(3′-(1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- pyrazol-5-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)methanol
296
2-chloro-5-(5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-1H- pyrazol-1-yl)pyridine
297
(3′-(1-(6-chloropyridin-3-yl)-1H- pyrazol-5-yl)-3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
298
(3′-(1-(6-chloropyridin-3-yl)-1H- pyrazol-5-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)methanol
299
(3′-(1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-3- methyl-1H-pyrazol-5-yl)-3-fluoro-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
300
(3′-(1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-3- methyl-1H-pyrazol-5-yl)-4′-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3-(methylsulfonyl)biphenyl-4- yl)methanol
301
1-(4-(difluoromethoxy)phenyl)-3- methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-1H- pyrazole
302
(3′-(1-(4-(difluoromethoxy)phenyl)-3- methyl-1H-pyrazol-5-yl)-4′-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
303
4-(fluoromethyl)-3′-(3-methyl-1-(4- (trifluoromethoxy)phenyl)-1H-pyrazol- 5-yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-3-ol
304
1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-3-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-1H-pyrazole
354
5-(4-chlorophenyl)-4-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1,3-oxazole
355
{3′-[4-(4-chlorophenyl)-1,3-oxazol-5- yl]-3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
356
(4′-(4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl)-3-fluoro-5- (methylsulfonyl)-3′-(4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)biphenyl-4-yl)methanol
357
N-methyl-4′-[2-[2-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-5-yl)biphenyl-3-sulfonamide
358
N,N-dimethyl-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl]- 3′-(4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-5-yl)biphenyl-3-sulfonamide
359
[3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-(4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-5-yl)biphenyl-4-yl]methanol
360
4-(4-chlorophenyl)-5-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1,3-oxazole
361
5-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazole
362
5-{4-[4-(1,1-difluoroethyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazole
363
{4′-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-3-fluoro-5- (methylsulfonyl)-3′-(4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-5-yl)biphenyl-4-yl}methanol
364
5-{4-[4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl]-3′- (methylsulfonyl)biphenyl-3-yl}-4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazole
365
{3′-[5-(4-chlorophenyl)-1,3-oxazol-4- yl]-3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol
366
2-methyl-4-{3′-(methylsulfonyl)-4-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-3-yl}-5-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazole
367
5-(4-(difluoromethoxy)-3,5- difluorophenyl)-2-methyl-4-(4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazole
368
2,2-difluoro-5-(2-methyl-4-(4-2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- methylsulfonyl)biphenyl-3-yl)oxazol- 5-yl)-2,3-dihydrobenzofuran-3-ol
369
(1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-2- methyl-1H-imidazol-4-yl)methanol
370
2-(1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- (methylsulfonyl)biphenyl-4-yl)-2- methyl-1H-imidazol-4-yl)propan-2-ol
371
1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-2- methyl-1H-imidazole-4-carbonitrile
372
1-(1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)- 2-methyl-1H-imidazol-4-yl)ethanol
373
[3-fluoro-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]-3′-(2-methyl-5-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-4-yl)biphenyl-4-yl]methanol
374
{3′-[5-(4-chlorophenyl)-2-methyl-1,3- oxazol-4-yl]-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
375
5-(4-chlorophenyl)-2-methyl-4-{3′- (methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-1,3-oxazole
376
5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
377
(3′-(5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
378
3-(4-(3′-fluoro-4′-(hydroxymethyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′- (methylsulfonyl)biphenyl-3-yl)-2- methyloxazol-5-yl)-1- isopropylpyridin-2(1H)-one
379
1-isopropyl-3-(2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazol- 5-yl)pyridin-2(1H)-one
380
5-(4-(difluoromethoxy)-3- methoxyphenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
381
(3′-(5-(4-(difluoromethoxy)-3- methoxyphenyl)-2-methyloxazol-4-yl)- 3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
382
5-(3-(cyclopropylmethoxy)-4- (difluoromethoxy)phenyl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
383
(3′-(5-(3-(cyclopropylmethoxy)-4- (difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
384
5-(6-(difluoromethoxy)pyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
385
(3′-(5-(6-(difluoromethoxy)pyridin-3- yl)-2-methyloxazol-4-yl)-3-fluoro-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
386
5-(3-cyclopropoxy-4- (difluoromethoxy)phenyl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
387
(3′-(5-(3-cyclopropoxy-4- (difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
388
5-(2-(difluoromethoxy)pyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
389
(3′-(5-(2-(difluoromethoxy)pyridin-3- yl)-2-methyloxazol-4-yl)-3-fluoro-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
390
5-(2-cyclopropylpyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
391
(3′-(5-(2-cyclopropylpyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
392
5-(3,4-bis(difluoromethoxy)phenyl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
393
(3′-(5-(3,4- bis(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
394
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-5- (2-methylpyridin-3-yl)oxazole
395
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(2-methylpyridin-3- yl)oxazol-4-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
396
5-(2-chloro-4- (difluoromethoxy)phenyl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
397
(3′-(5-(2-chloro-4- (difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
398
5-(3-chloro-4- (difluoromethoxy)phenyl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
399
(3′-(5-(3-chloro-4- (difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
400
5-(5-fluoro-2-methoxypyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
401
(3-fluoro-3′-(5-(5-fluoro-2- methoxypyridin-3-yl)-2-methyloxazol- 4-yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
402
(3′-(5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)methanol
404
5-(4-(cyclopropylmethoxy)-3- fluorophenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
405
(3′-(5-(4-(cyclopropylmethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
406
5-(4-(1,3-difluoropropan-2-yloxy)-3- fluorophenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
407
(3′-(5-(4-(1,3-difluoropropan-2-yloxy)- 3-fluorophenyl)-2-methyloxazol-4-yl)- 3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
408
5-(6-(cyclohexyloxy)pyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
409
(3′-(5-(6-(cyclohexyloxy)pyridin-3-yl)- 2-methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- methylsulfonyl)biphenyl-4- yl)methanol
410
5-(6-(cyclopentyloxy)pyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
411
(3′-(5-(6-(cyclopentyloxy)pyridin-3- yl)-2-methyloxazol-4-yl)-3-fluoro-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
412
5-(5-methoxypyrazin-2-yl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
413
(3-fluoro-3′-(5-(5-methoxypyrazin-2- yl)-2-methyloxazol-4-yl)-4′-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 5-(methylsulfonyl)biphenyl-4- yl)methanol
414
5-(2-methoxypyrimidin-5-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
415
(3-fluoro-3′-(5-(2-methoxypyrimidin- 5-yl)-2-methyloxazol-4-yl)-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
416
4-(3′-(cyclopropylsulfonyl)-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-[1,1′-biphenyl]-3-yl)-5- (2,2-difluorobenzo[d][1,3]dioxol-5-yl)- 2-methyloxazole
417
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-4-(3′-(difluoromethylsulfonyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)biphenyl-3-yl)-2- methyloxazole
418
3′-(5-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazol-4-yl)-N,N- dimethyl-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl)biphenyl-3-carboxamide
419
5-(2,2-dimethyl-2,3- dihydrobenzofuran-5-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
420
3′-(5-(2,2-dimethyl-2,3- dihydrobenzofuran-5-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
421
(3′-(5-(5-chloropyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
422
5-(2-chloro-6-methylpyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
423
4-(4-(4-chloro-2-methyl-1H-imidazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3- yl)-5-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-2-methyloxazole
424
(4′-(4-chloro-2-methyl-1H-imidazol-1- yl)-3′-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3-fluoro-5- (methylsulfonyl)biphenyl-4- yl)methanol
425
5-(4-(2,2-difluoroethoxy)-3- fluorophenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
426
(3′-(5-(4-(2,2-difluoroethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
427
(3′-(5-(6-chloropyridin-2-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
428
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(2-methylpyrimidin-5- yl)oxazol-4-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
429
4-(3′-(cyclopropylsulfonyl)-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)biphenyl-3-yl)-5-(4- (difluoromethoxy)-3-fluorophenyl)-2- methyloxazole
430
5-(4-(difluoromethoxy)-3- fluorophenyl)-4-(3′- (difluoromethylsulfonyl)-4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1- yl)biphenyl-3-yl)-2-methyloxazole
431
5-(5-chloropyridin-2-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
432
(3′-(5-(2-chloro-6-methylpyridin-4-yl)- 2-methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
433
4-(3′-(cyclopropylsulfonyl)-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)biphenyl-3-yl)-5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazole
434
5-(4-chloropyridin-2-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
435
5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyl-4-(4′-methyl- 4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
436
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-5- (naphthalen-2-yl)oxazole
437
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(naphthalen-2- yl)oxazol-4-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
438
1-(3′-(5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)biphenyl-3- yl)cyclopropanecarboxamide
439
5-(5-fluoro-6-methoxypyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
440
(3-fluoro-3′-(5-(5-fluoro-6- methoxypyridin-3-yl)-2-methyloxazol- 4-yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
441
5-(6-chloropyridin-2-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
442
3′-(5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)- N,N-dimethyl-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl)biphenyl-3-carboxamide
443
5-(2,3-dihydrobenzo[b][1,4]dioxin-6- yl)-2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
444
3′-(5-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
445
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyl-4-(4′-methyl-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
446
1-(3′-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl)biphenyl-3- yl)cyclopropanecarboxamide
447
5-(3,5-difluorophenyl)-2-methyl-4-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
448
(3′-(5-(3,5-difluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
449
5-(3-chloro-5-fluorophenyl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
450
(3′-(5-(3-chloro-5-fluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
451
5-(2-chloro-6-methylpyridin-4-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
452
(3′-(5-(2-chloro-6-methylpyridin-4-yl)- 2-methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
453
5-(2,4-difluorophenyl)-2-methyl-4-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
454
(3′-(5-(2,4-difluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
455
5-(3,5-dichlorophenyl)-2-methyl-4-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
456
(3′-(5-(3,5-dichlorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
457
(3′-(5-(4-(difluoromethoxy)-3,5- difluorophenyl)-2-methyloxazol-4-yl)- 3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
458
5-(4-chloro-3- (difluoromethoxy)phenyl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
459
(3′-(5-(4-chloro-3- (difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
460
5-(3-(difluoromethoxy)-4- fluorophenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
461
(3′-(5-(3-(difluoromethoxy)-4- fluorophenyl)-2-methyloxazol-4-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- methylsulfonyl)biphenyl-4- yl)methanol
462
5-(4-(difluoromethoxy)-3- fluorophenyl)-4-(3′-fluoro-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′- methylsulfonyl)biphenyl-3-yl)-2- methyloxazole
463
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-4-(3′-fluoro-4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 5′-(methylsulfonyl)biphenyl-3-yl)-2- methyloxazole
464
4-(4-(4-chloro-2-methyl-1H-imidazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3- yl)-5-(5-fluoro-6-methoxypyridin-3- yl)-2-methyloxazole
465
(4′-(4-chloro-2-methyl-1H-imidazol-1- yl)-3-fluoro-3′-(5-(5-fluoro-6- methoxypyridin-3-yl)-2-methyloxazol- 4-yl)-5-(methylsulfonyl)biphenyl-4- yl)methanol
466
4-(4-(4-chloro-2-methyl-1H-imidazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3- yl)-5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazole
467
(4′-(4-chloro-2-methyl-1H-imidazol-1- yl)-3′-(5-(4-(difluoromethoxy)-3- fluorophenyl)-2-methyloxazol-4-yl)-3- fluoro-5-(methylsulfonyl)biphenyl-4- yl)methanol
468
4-(4-(4-chloro-2-methyl-1H-imidazol- 1-yl)-3′-(methylsulfonyl)biphenyl-3- yl)-5-(2-chloro-6-methylpyridin-4-yl)- 2-methyloxazole
469
(3′-(5-(4-(difluoromethoxy)-3,5- difluorophenyl)-2-methyloxazol-4-yl)- 4′-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)methanol
470
5-(4-(difluoromethoxy)-3,5- difluorophenyl)-2-methyl-4-(4′- methyl-4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
471
5-(6-ethoxy-5-fluoropyridin-3-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
472
(3′-(5-(6-ethoxy-5-fluoropyridin-3-yl)- 2-methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
473
5-(6-ethoxy-5-fluoropyridin-3-yl)-2- methyl-4-(4′-methyl-4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
474
5-(2,3-dihydro-1H-inden-5-yl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
475
(3′-(5-(2,3-dihydro-1H-inden-5-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
476
5-(2-chloro-6-(trifluoromethyl)pyridin- 3-yl)-2-methyl-4-(4′-methyl-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
477
(3′-(5-(2-chloro-6- (trifluoromethyl)pyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
478
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-ethyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
479
(3′-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- ethyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
480
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-isopropyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
481
(3′-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- isopropyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
482
2-cyclopropyl-5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
483
(3′-(2-cyclopropyl-5-(2,2- difluorobenzo[d][1,3]dioxol-5- yl)oxazol-4-yl)-3-fluoro-4′-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 5-(methylsulfonyl)biphenyl-4- yl)methanol
484
5-(4-chloro-2-fluorophenyl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
485
(3′-(5-(4-chloro-2-fluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
486
5-(2,4-dichlorophenyl)-2-methyl-4-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
487
2,2-difluoro-5-(4-(3′-fluoro-4′- (hydroxymethyl)-4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 5′-(methylsulfonyl)biphenyl-3-yl)-2- methyloxazol-5-yl)-2,3- dihydrobenzofuran-3-ol
488
(3′-(5-(2,4-dichlorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
489
1-(3-(2-cyclopropyl-5-(2,2- difluorobenzo[d][1,3]dioxol-5- yl)oxazol-4-yl)-3′- (methylsulfonyl)biphenyl-4-yl)-2- methyl-1H-imidazole-4-carboxamide
490
1-(3-(2-cyclopropyl-5-(2,2- difluorobenzo[d][1,3]dioxol-5- yl)oxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′- methylsulfonyl)biphenyl-4-yl)-2- methyl-1H-imidazole-4-carboxamide
491
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(p-tolyl)oxazole
492
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-p-tolyloxazol-4-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
493
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
494
(3′-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
495
5-(4-(difluoromethoxy)phenyl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazole
496
(3′-(5-(4-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
497
(3′-(5-(4-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)methanol
498
5-(4-chloro-3-fluorophenyl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
499
(3′-(5-(4-chloro-3-fluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- methylsulfonyl)biphenyl-4- yl)methanol
500
N,N-dimethyl-4-(2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazol- 5-yl)aniline
501
1-(4-(4-(3′-fluoro-4′-(hydroxmethyl)- 4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′- (methylsulfonyl)biphenyl-3-yl)-2- methyloxazol-5-yl)phenyl)pyrrolidin- 2-one
502
1-(4-(2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazol-5-yl)phenyl)pyrrolidin-2-one
503
(3-fluoro-3′-(5-(3-fluoro-4- methylphenyl)-2-methyloxazol-4-yl)- 4′-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
504
5-(3-fluoro-4-methylphenyl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
505
5-(4-fluorophenyl)-2-methyl-4-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
506
2-fluoro-5-(2-methyl-4-(4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3- yl)oxazol-5-yl)benzonitrile
507
(3′-(5-(3,4-dichlorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
508
5-(3,4-dichlorophenyl)-2-methyl-4-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
509
(3′-(5-(3-chloro-4-fluorophenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
510
5-(3-chloro-4-fluorophenyl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
511
5-(3,4-difluorophenyl)-2-methyl-4-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)oxazole
512
(3′-(5-(3,4-difluorophenyl)-2- methyloxazol-4-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)biphenyl-4- yl)methanol
513
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-5- (4-(trifluoromethyl)phenyl)oxazole
514
1-(1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′- (methylsulfonyl)-[1,1′-biphenyl]-4-yl)- 2-methyl-1H-imidazol-4-yl)ethanol One enantiomer
515
1-(1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-2-methyl-1H- imidazol-4-yl)ethanol, one enantiomer
516
1-(1-(3-(5-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-4-yl)-3′-fluoro-4′- (hydroxymethyl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)-2-methyl-1H- imidazol-4-yl)ethanol, another enantiomer
517
4-(4-(4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazole
518
(4′-(4-(1,1-difluoropropyl)-2-methyl- 1H-imidazol-1-yl)-3-fluoro-3′-(2- methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-5-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)methanol
519
(3′-(2-ethyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
520
4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-2-propyl-5-(4- (trifluoromethoxy)phenyl)oxazole
521
(3′-(2-isopropyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
522
(4′-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-3-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)methanol
523
2-(4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-3-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)ethanol
524
2-(4-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)ethanol
525
2-(4-(3′-fluoro-4′-(hydroxymethyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)ethanol
526
2-(4-(4′-(hydroxymethyl)-4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- trifluoromethoxy)phenyl)oxazol-2- yl)ethanol
527
(3-fluoro-3′-(2-(2-methoxyethyl)-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
528
2-(4-(3′-fluoro-4′-(hydroxymethyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)-2-methylpropan-1-ol
529
2-(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-5-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)ethanol
530
2-(5-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-4-(3′-fluoro-4′-(hydroxymethyl)- 4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazol-2- yl)ethanol
531
2-(5-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazol-2-yl)ethanol
532
5-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-4-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-2-vinyloxazole
533
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfinyl)-[1,1′-biphenyl]-3- yl)-5-(4- (trifluoromethoxy)phenyl)oxazole
534
1-(4-(3′-fluoro-4′-(hydroxymethyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)propan-2-ol
535
1-(4-(4′-(hydroxymethyl)-4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)propan-2-ol
536
1-(4-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)propan-2-ol
537
2-(4-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)acetic acid
538
N,N-dimethyl-1-(4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)methanamine
539
4-(3′-((methoxymethyl)sulfonyl)-4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-[1,1′-biphenyl]-3-yl)-2- methyl-5-(4- (trifluoromethoxy)phenyl)oxazole
540
3′-(5-(4-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-N-methyl-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-[1,1′-biphenyl]-3- sulfonamide
541
3′-(5-(4-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-N,N-dimethyl-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-[1,1′-biphenyl]-3- sulfonamide
542
2-(3′-(5-(4-(difluoromethoxy)phenyl)- 2-methyloxazol-4-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- [1,1′-biphenyl]-3-yl)-2- methylpropanamide
543
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(4- ((trifluoromethyl)thio)phenyl)oxazol- 4-yl)-5-(methylsulfonyl)-[1,1′- biphenyl]-4-yl)methanol
544
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(4-(1,1,2,2- tetrafluoroethoxy)phenyl)oxazol-4-yl)- 5-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
545
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(3- (trifluoromethoxy)phenyl)oxazol-4- yl)-5-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)methanol
546
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(3-(1,1,2,2- tetrafluoroethoxy)phenyl)oxazol-4-yl)- 5-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
547
5-(2-(difluoromethoxy)phenyl)-2- methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazole
548
(3′-(5-(2-(difluoromethoxy)phenyl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
549
(3′-(5-(2-chloropyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
550
5-(6-chloropyridin-3-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
551
(3′-(5-(6-chloropyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
552
5-(2-chloropyridin-3-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
553
5-(2,4-dichlorophenyl)-2-(2- methoxyethyl)-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazole
554
2-(4-(3′-fluoro-4′-(hydroxymethyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)propan-1-ol
555
2-ethyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- (trifluoromethoxy)phenyl)oxazole
556
(3′-(2-ethyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
557
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-3′-(2-propyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-[1,1′-biphenyl]-4-yl)methanol
558
(4′-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3-(methylsulfonyl)-3′- (2-propyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-[1,1′-biphenyl]-4-yl)methanol
559
2-isopropyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- (trifluoromethoxy)phenyl)oxazole
560
(3-fluoro-3′-(2-isopropyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
561
(3-fluoro-3′-(2-isobutyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
562
2-isobutyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- (trifluoromethoxy)phenyl)oxazole
563
(3′-(2-isobutyl-5-(4- (trifluoromethoxy)phenyl)oxazol-4- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
564
2-(2-methoxyethyl)-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- (trifluoromethoxy)phenyl)oxazole
565
2-(4-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-5-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)propan-1-ol
566
5-(2,6-dichloropyridin-3-yl)-2-methyl- 4-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
567
(3′-(5-(2,6-dichloropyridin-3-yl)-2- methyloxazol-4-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
568
(3-fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(2-methyl-5-(6- (trifluoromethyl)pyridin-3-yl)oxazol-4- yl)-5-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl)methanol
569
5-(6-methoxypyridin-3-yl)-2-methyl-4- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
570
(3-fluoro-3′-(5-(6-methoxypyridin-3- yl)-2-methyloxazol-4-yl)-4′-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 5-(methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
571
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- ((trifluoromethyl)thio)phenyl)oxazole
572
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(4- (perfluoroethoxy)phenyl)oxazole
573
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(3- (trifluoromethoxy)phenyl)oxazole
574
2-methyl-4-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-5-(3- (perfluoroethoxy)phenyl)oxazole
600
{3′-(2-ethyl-4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-5-yl)-3-fluoro-5- (methylsulfonyl)-4′-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-4-yl}methanol
601
{3-fluoro-3′-[2-(1-methylethyl)-4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazol-5-yl]-5-(methylsulfonyl)-4′-[2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl]biphenyl-4-yl}methanol;
602
5-{3′-(methylsulfonyl)-4-[2-methyl-4- (trifluoromethyl)-1H-imidazol-1- yl]biphenyl-3-yl}-2-propyl-4-{4- [(trifluoromethyl)oxy]phenyl}-1,3- oxazole
603
(3-fluoro-3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
604
2-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- (trifluoromethoxy)phenyl)oxazole BMS-930815/EXEL-04613389
605
4-(4-chlorophenyl)-2-methyl-5-(4-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
606
(3′-(4-(4-chlorophenyl)-2- methyloxazol-5-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
607
(3′-(2-methyl-4-(4- (trifluoromethoxy)phenyl)oxazol-5- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
608
4-(2,4-dichlorophenyl)-2-methyl-5-(4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
609
(3′-(4-(2,4-dichlorophenyl)-2- methyloxazol-5-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
610
2-(5-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-4-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)acetic acid
611
2-(5-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-4-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)ethanol
612
2-(5-(3′-fluoro-4′-(hydroxymethyl)-4- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-4-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)ethanol
613
2-(5-(4′-(hydroxymethyl)-4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-4-(4- (trifluoromethoxy)phenyl)oxazol-2- yl)ethanol
614
(3′-(4-(2,4-dichlorophenyl)-2- methyloxazol-5-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
615
4-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazole
616
(3′-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
617
(3′-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
618
2-(4-(4-chlorophenyl)-5-(4-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazol-2-yl)ethanol
619
4-(4-(difluoromethoxy)phenyl)-2- methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazole
620
5-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-2-(2-(pyrrolidin- 1-yl)ethyl)-4-(4- (trifluoromethoxy)phenyl)oxazole
621
2-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-5-(3′-fluoro-4′-(hydroxymethyl)- 4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazol-2- yl)ethanol
622
2-(4-(2,2-difluorobenzo[d][1,3]dioxol- 5-yl)-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazol-2-yl)ethanol
623
(3-chloro-3′-(4-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- methyloxazol-5-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
624
(3′-(4-(4-(difluoromethoxy)phenyl)-2- methyloxazol-5-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
625
(3′-(4-(4-(difluoromethoxy)phenyl)-2- methyloxazol-5-yl)-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-3- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
626
2-(2-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazol-4-yl)-5- (trifluoromethoxy)phenol
627
2-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfinyl)-[1,1′-biphenyl]-3- yl)-4-(4- (trifluoromethoxy)phenyl)oxazole
628
N,N-dimethyl-2-(5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- (trifluoromethoxy)phenyl)oxazol-2- yl)ethanamine
629
2-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-4-(2- (trifluoromethyl)phenyl)oxazole
630
(3-fluoro-3′-(2-methyl-4-(2- (trifluoromethyl)phenyl)oxazol-5-yl)- 4′-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
631
2-methyl-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)-4-(2- (trifluoromethoxy)phenyl)oxazole
632
(3-fluoro-3′-(2-methyl-4-(2- (trifluoromethoxy)phenyl)oxazol-5- yl)-4′-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
633
(3′-(4-(4-chlorobenzyl)oxazol-5-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)-[1,1′-biphenyl]-4- yl)methanol
634
4-(4-chlorobenzyl)-5-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)-[1,1′-biphenyl]-3- yl)oxazole
635
(3′-(4-(4-chlorobenzyl)oxazol-5-yl)-4′- (2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol
636
5-(4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-4-(4- (trifluoromethoxy)benzyl)oxazole
637
4-(2-methoxy-4- (trifluoromethoxy)phenyl)-2-methyl-5- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)oxazole
638
(3′-(1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-4- (trifluoromethyl)-1H-imidazol-2-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- methylsulfonyl)biphenyl-4- yl)methanol
639
(3′-(4-cyclopropyl-1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-1H- imidazol-2-yl)-3-fluoro-4′-(2-methyl- 4-(trifluoromethyl)-1H-imidazol-1-yl)- 5-(methylsulfonyl)biphenyl-4- yl)methanol
640
1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-(4-(2-methyl-4-(trifluoromethyl)- 1H-imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)-4- (trifluoromethyl)-1H-imidazole
641
1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl)-2-(3′-fluoro-4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 5′-(methylsulfonyl)biphenyl-3-yl)-4- (trifluoromethyl)-1H-imidazole
642
2-chloro-5-(2-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-4- (trifluoromethyl)-1H-imidazol-1- yl)pyridine
643
4-cyclopropyl-1-(2,2- difluorobenzo[d][1,3]dioxol-5-yl)-2- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′- (methylsulfonyl)biphenyl-3-yl)-1H- imidazole
644
1-(4-chlorophenyl)-2-(4-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)- 3′-(methylsulfonyl)biphenyl-3-yl)-4- (trifluoromethyl)-1H-imidazole
645
(3′-(1-(4-chlorophenyl)-4- (trifluoromethyl)-1H-imidazol-2-yl)-3- fluoro-4′-(2-methyl-4- (trifluoromethyl)-1H-imidazol-1-yl)-5- (methylsulfonyl)biphenyl-4- yl)methanol
646
1-(4-chlorophenyl)-4-cyclopropyl-2- (4-(2-methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-3′-(methylsulfonyl)- [1,1′-biphenyl]-3-yl)-1H-imidazole
647
(3′-(1-(4-chlorophenyl)-4-cyclopropyl- 1H-imidazol-2-yl)-3-fluoro-4′-(2- methyl-4-(trifluoromethyl)-1H- imidazol-1-yl)-5-(methylsulfonyl)- [1,1′-biphenyl]-4-yl)methanol.
15. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers.
16. A method of therapeutically treating a disease or disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 , wherein the disease or disorder is atherosclerosis, insulin resistance, osteoarthritis, stroke, hyperglycemia, dyslipidemia, psoriasis, aged and UV skin wrinkling, diabetes, inflammation, immunological disorders, lipid disorders, obesity, conditions characterized by a perturbed epidermal barrier function, conditions of disturbed differentiation or excess proliferation of the epidermis or mucous membrane, or cardiovascular disorders.
17. The method of claim 16 , wherein the disease or disorder is atherosclerosis, diabetes, or dyslipidemia.
18. The method of claim 17 , wherein the disease or disorder is atherosclerosis.
19. The method of claim 17 , wherein the disease or disorder is diabetes.