IP Library › Patent Application 14775055
Patent Application
App. No. 14/775,055

Genetically Modified Bacteria

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Quick Facts
Patent No.
US None
App. No.
14/775,055
Abstract

The present invention relates to genetically modified methylotrophic bacteria.

Claims (30)

1 . A recombinant bacterium cell

genetically modified to disrupt the cell's H 4 MPT pathway for C 1 dissimilation and to include a recombinant RuMP pathway for C 1 dissimilation.

2 . The recombinant bacterium cell of claim 1 being a Methylobacterium.

3 . The recombinant bacterium cell of claim 1 being a Methylobacterium extorquens.

4 . The recombinant bacterium cell of claim 1 being a Methylobacterium extorquens PA1.

5 . A recombinant bacterium cell

genetically modified to disrupt the cell's serine cycle for C 1 assimilation and to include a recombinant RuMP pathway for C 1 assimilation.

6 . The recombinant bacterium cell of claim 5 being a Methylobacterium.

7 . The recombinant bacterium cell of claim 5 being a Methylobacterium extorquens.

8 . The recombinant bacterium cell of claim 5 being a Methylobacterium extorquens PA1.

9 . A recombinant bacterium cell

genetically modified to disrupt the cell's H 4 MPT pathway for C 1 dissimilation, to disrupt the cell's serine cycle for C 1 assimilation and to include a recombinant RuMP pathway for C 1 assimilation and C 1 dissimilation.

10 . The recombinant bacterium cell of claim 9 being a Methylobacterium.

11 . The recombinant bacterium cell of claim 9 being a Methylobacterium extorquens.

12 . The recombinant bacterium cell of claim 9 being a Methylobacterium extorquens PA1.

13 . A method of making a genetically modified bacterium comprising

genetically modifying a target bacterium to disrupt the target bacterium's H 4 MPT pathway for C 1 dissimilation and to include a recombinant RuMP pathway for C 1 dissimilation.

14 . The method of claim 13 wherein the target bacterium is a Methylobacterium.

15 . The method of claim 13 wherein the target bacterium is a Methylobacterium extorquens.

16 . The method of claim 13 wherein the target bacterium is a Methylobacterium extorquens PA1.

17 . A method of making a genetically modified bacterium comprising

genetically modifying a target bacterium to disrupt the target bacterium's serine cycle for C 1 assimilation and to include a recombinant RuMP pathway for C 1 assimilation.

18 . The method of claim 17 wherein the target bacterium is a Methylobacterium.

19 . The method of claim 17 wherein the target bacterium is a Methylobacterium extorquens.

20 . The method of claim 17 wherein the target bacterium is a Methylobacterium extorquens PA1.

21 . A method of making a genetically modified bacterium comprising

genetically modifying a target bacterium to disrupt the target bacterium's H 4 MPT pathway for C 1 dissimilation, to disrupt the target bacterium's serine cycle for C 1 assimilation and to include a recombinant RuMP pathway for C 1 assimilation and C 2 dissimilation.

22 . The method of claim 21 wherein the target bacterium is a Methylobacterium.

23 . The method of claim 21 wherein the target bacterium is a Methylobacterium extorquens.

24 . The method of claim 21 wherein the target bacterium is a Methylobacterium extorquens PA1.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 23, 2015
From: MARX, CHRISTOPHER J.; NAYAK, DIPTI D.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 037118/0076 →