Process and systems for obtaining 1,4-butanediol from fermentation broths

1. A process of purifying 1,4-butanediol (1,4-BDO) comprising:

(a) subjecting a crude 1,4-BDO mixture to a first column distillation procedure to remove materials with a boiling point lower than 1,4-BDO from the crude 1,4-BDO mixture to produce a first 1,4-BDO-containing product stream;

(b) subjecting the first 1,4-BDO-containing product stream to a first intermediate column distillation procedure to remove materials with a boiling point higher than 1,4-BDO, as a first high boilers stream, to produce a second 1,4-BDO-containing product stream exiting from the top of the first intermediate column, and

treating the second 1,4-BDO-containing product stream with a hydrogenation reaction prior to step (d);

(c) subjecting the first high-boilers stream to wiped-film evaporation (WFE) to produce a WFE distillate and subjecting the WFE distillate to step (b);

(d) subjecting the second 1,4-BDO-containing product stream to a second intermediate column distillation procedure to remove materials with a boiling point lower than 1,4-BDO, to produce a third 1,4-BDO-containing product stream; and

(e) subjecting the third 1,4-BDO-containing product stream to a second column distillation procedure to remove materials with boiling points higher than 1,4-BDO as a second high-boilers stream, to produce a purified 1,4-BDO product;

wherein the crude 1,4-BDO mixture comprises 80% to 85% 1,4-BDO with 1% to 25% water; recovery of the purified 1,4-BDO product from the crude 1,4-BDO mixture is greater than 98%; and the purified 1,4-BDO product is greater than 98% (w/w) 1,4-BDO.

2. The process of claim 1 , wherein the purified 1,4-BDO product is collected as a distillate of the second column distillation procedure.

3. The process of claim 1 further comprising culturing a modified non-naturally occurring organism to produce 1,4-BDO in a fermentation broth, subjecting the fermentation broth to a separation procedure to obtain a separated 1,4-BDO product, and subjecting the separated 1,4-BDO product to water removal and salt removal to produce the crude 1,4-BDO mixture, wherein the separation procedure consists of a first filtration and a second filtration, wherein the first filtration is microfiltration or ultrafiltration, and wherein the second filtration is nanofiltration.

4. The process of claim 3 further comprising subjecting the crude 1,4-BDO mixture to a polishing ion exchange using a polishing ion exchange resin that is an anion exchange resin.

5. The process of claim 3 , wherein the water removal is by evaporation.

6. The process of claim 3 , wherein the salt removal is by primary ion exchange.

7. The process of claim 6 , wherein the primary ion exchange resin comprises a cation exchange resin and a anion exchange resin.

8. The process of claim 1 , wherein the purified 1,4-BDO product is collected from a side draw of the second column distillation procedure.

9. The process of claim 1 , wherein the purified 1,4-BDO product has less than 0.04 percent 2-(4-hydroxybutoxy) tetrahydrofuran.