Two-layer separation-type eye drop containing squalane
The purpose of the present invention is to provide a technique for formulating a two-layer separation-type ophthalmic solution in which, during storage, an aqueous layer and an oil-containing layer containing squalane are separated from each other, wherein it is possible to homogeneously disperse the oil-containing layer in the aqueous layer while suppressing foaming by shaking the ophthalmic solution before administration, and the homogeneous dispersed state is maintained in a stable manner at least until administration. A two-layer separation-type ophthalmic solution containing squalane and water, wherein hyaluronic acid and/or a salt thereof and polyvinyl alcohol are contained in the ophthalmic solution and the polyvinyl alcohol content is set to 0.025 to 0.1 w/v %, whereby it is possible to homogeneously disperse the oil-containing layer in the aqueous layer while suppressing foaming by shaking the ophthalmic solution before administration, and to maintain the homogeneous dispersed state in a stable manner at least until administration.
1. A two-layer separation-type ophthalmic solution comprising an oil-containing layer and an aqueous layer, wherein
when statically stored, an upper layer consisting of the oil-containing layer and a lower layer consisting of the aqueous layer are formed, the oil-containing layer contains squalane,
the aqueous layer contains hyaluronic acid and/or its salt and polyvinyl alcohol, with 0.3 to 0.4 w/v % of hyaluronic acid and/or its salt and 0.025 to 0.1 w/v % of polyvinyl alcohol being present in the ophthalmic solution.
2. The two-layer separation-type ophthalmic solution according to claim 1 , comprising 1 to 10 w/v % of squalane.
3. The two-layer separation-type ophthalmic solution according to claim 1 wherein the ophthalmic solution is for non-human mammals.
4. The two-layer separation-type ophthalmic solution according to claim 1 , comprising 0.2 to 10 parts by weight of polyvinyl alcohol per 100 parts by weight of squalane.
5. The two-layer separation-type ophthalmic solution according to claim 1 , wherein the ophthalmic solution is for treatment of dry eye.
6. The two-layer separation-type ophthalmic solution according to claim 1 wherein the ophthalmic solution is for protecting cornea.
7. A method of treating dry eye, comprising a step of administering the two-layer separation-type ophthalmic solution according to claim 1 to mammalian eyes suffering from dry eye.
8. A method of protecting the cornea, comprising a step of administering the two-layer separation-type ophthalmic solution according to claim 1 to mammalian eyes requiring corneal protection.