Combination Therapy for Subcutaneous Administration of Glycopeptide Antibiotics
A combination drug therapy is disclosed for the treatment of a patient, such as a human, with a glycopeptide antibiotic. The methods can include subcutaneous administration to a patient of a therapeutically effective amount of a glycopeptide antibiotic, for example, vancomycin, and a compound belonging to the cromones class of anti-inflammatory agents such as cromolyn sodium. The present teachings also provide a therapeutic combination and a kit including the therapeutic combination.
1 . A method of treating a bacterial infection or alleviating one or more symptoms thereof in a patient, the method comprising:
administering subcutaneously to a patient a therapeutically effective amount of a glycopeptide antibiotic and a cromone.
2 . The method of claim 1 wherein the glycopeptide antibiotic is vancomycin.
3 . The method of claim 1 wherein glycopeptide antibiotic is teicoplanin.
4 . The method of claim 1 wherein the glycopeptide antibiotic is a lipoglycopeptide.
5 . The method of claim 4 wherein the lipoglycopeptide is telavancin.
6 . The method of claim 4 wherein the lipoglycopeptide is oritavancin.
7 . The method of claim 4 Wherein the lipoglycopeptide is dalbavancin.
8 . The method of claim 2 wherein the cromone is cromolyn.
9 . The method of claim 2 wherein the cromone is nedocromil.
10 . A therapeutic combination comprising a glycopeptide and a cromone.
11 . A kit comprising:
a therapeutic combination of claim 10 ; and
instructions for use of the therapeutic combination.