Formulation of growth hormone albumin-binder conjugate
The present invention relates to compositions of growth hormone albumin-binder conjugates including pharmaceutical formulations. The compositions are able to provide initial and long term stability of the growth hormone albumin-binder conjugate, rendering such compositions suited for use as a pharmaceutical formulation.
1. A pharmaceutical composition comprising
5-10 mg/mL growth hormone albumin binder conjugate,
1-3 mg/mL poloxamer 188,
0.5-1.0 mg/mL histidine buffer,
40-45 mg/mL mannitol,
3-4 mg/mL phenol, and
pH of 6.5-7.0,
wherein the growth hormone conjugate is
2. A pharmaceutical composition comprising
5-10 mg/ml growth hormone albumin binder conjugate,
1.0 mg/mL poloxamer 188,
0.68 mg/mL histidine buffer,
44 mg/ml mannitol,
4 mg/mL phenol, and
pH of 6.8;
wherein the growth hormone conjugate is