Isodose optimization

1. A radiation therapy planning system, comprising:

one or more processors configured to:

receive or construct isodose lines from a source dose grid planned for a volume of a subject, wherein the isodose lines are representative of a shape of a radiation delivery device source beam passing through a multi-leaf collimator;

define at least one isodose region of interest, the at least one isodose region of interest being a subset of subject voxels that are defined by-the received or constructed isodose lines; and

generate an optimized deliverable radiation therapy plan based on the at least one isodose region of interest and at least one dose objective for the at least one isodose region of interest.

2. The system according to claim 1 , wherein:

the one or more processors are further configured to receive or construct dose volume histograms from a source dose distribution planned for the volume of the subject and

wherein the at least one dose objective is based on the received or constructed dose volume histograms.

3. The system according to claim 2 , further including:

a user interface configured to visualize the received or constructed dose volume histograms or the received or constructed isodose lines, and to allow a healthcare practitioner to modify one of the visualized dose volume histograms or the visualized isodose lines;

a display device configured to display the visualized dose volume histograms and the visualized isodose lines; and

at least one input device configured to receive the healthcare practitioner modifications to one of the visualized dose volume histograms or the visualized isodose lines.

4. The system according to claim 1 , wherein the at least one isodose region of interest includes

a volume bounded between two isodose lines of the received or constructed isodose lines.

5. The system according to claim 1 , wherein the at least one dose objective includes a result of a function of dose values associated with isodose lines of the received or constructed isodose lines which define the at least one isodose region of interest.

6. The system according to claim 1 , wherein the at least one dose objective includes at least one of:

at least one of a uniform dose objective or a minimum dose objective for the an isodose region of interest corresponding to a highest isodose for a target volume;

at least one of a uniform dose objective, a minimum dose objective, or a minimum dose volume objective for an isodose region of interest corresponding to a lower isodose for the target volume; or

a maximum dose objective for a defined at least one isodose region of interest outside the target volume.

7. The system according to claim 1 , wherein:

the one or more processors are further configured to filter at least a portion of the at least one isodose region of interest based on smoothing a surface of the region of interest.

8. The system according to claim 1 , wherein the deliverable radiation therapy plan includes control signals for a radiation therapy device to deliver external beams of radiation in either one of: a step and shoot technique, or a continuous movement technique.

9. The system according to claim 8 , wherein the control signals include instructions for beam quantity and MLC shapes.

10. A method of radiation therapy planning, comprising:

receiving or constructing isodose lines from a source grid planned for a volume of a subject, wherein the isodose lines are representative of a shape of a radiation delivery device source beam passing through a multi-leaf collimator;

defining at least one isodose region of interest, the defined at least one isodose region of interest being a subset of subject voxels that are defined by the received or constructed isodose lines; and

generating an optimized deliverable radiation therapy plan based on the defined at least one isodose region of interest and at least one dose objective for the defined at least one isodose region of interest.

11. The method according to claim 10 , wherein receiving or constructing further includes:

receiving or constructing dose volume histograms planned for the subject; and

wherein the at least one dose objective is based on the received or constructed dose volume histograms.

12. The method according to claim 10 , wherein receiving or constructing includes:

visualizing the received or constructed dose volume histograms and the received or constructed isodose lines superimposed on an image of the volume of the subject; and

modifying at least one of the visualized dose volume histograms or the visualized isodose lines.

13. The method according to claim 10 , wherein the defined at least one isodose region of interest includes a volume outside an isodose line of the received or constructed isodose lines.

14. The method according to claim 10 , wherein the at least one dose objective includes at least one of:

at least one of a uniform dose objective or a minimum dose objective for an isodose region of interest corresponding to a highest isodose for a target volume;

at least one of a uniform dose objective, a minimum dose objective, or a minimum dose volume objective for an isodose region of interest corresponding to a lower isodose for the target volume; or

a maximum dose objective for a defined at least one isodose ring region of interest outside the target volume.

15. The method according to claim 10 , further including:

filtering at least a portion of the defined at least one isodose region of interest based on

smoothing a surface of the at least one isodose region of interest.

16. A non-transitory computer-readable storage medium carrying software which controls one or more electronic data processing devices to perform the method according to claim 10 .

17. An electronic data processing device configured to perform the method according to claim 10 .

18. A radiation therapy planning system, comprising:

a display device;

at least one input device; and

one or more processors configured to:

receive planned isodose lines corresponding to a subject volume;

visualize the planned isodose lines superimposed on an image of the subject volume on the display device;

receive modifications of the visualized planned isodose lines from the at least one input device;

define at least one isodose region of interest which includes voxels delineated by the modified isodose lines;

calculate at least one dose objective for the defined at least one isodose region of interest; and

generate an optimized deliverable radiation therapy plan based on the defined at least one isodose region of interest and the calculated at least one dose objective for the defined at least one isodose region of interest.

19. The system according to claim 18 , wherein the at least one dose objective for the defined at least one isodose region of interest includes both a uniform dose objective and a minimum dose objective for an isodose region of interest corresponding to a highest isodose for a target volume.

20. The system according to claim 18 , wherein the at least one dose objective for the defined at least one isodose region of interest includes both a uniform dose objective and a minimum dose volume objective for an isodose region of interest corresponding to a lower isodose for a target volume.

21. The system according to claim 18 , wherein the at least one dose objective for the defined at least one isodose region of interest includes a maximum dose objective for a defined at least one isodose region of interest outside a target volume.