IP Library › Granted Patent US 9,512,165
Granted Patent B2
US 9,512,165 · App. 14/785,171 · Granted Dec 6, 2016

19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof

Inventors: Gabriel Martinez Botella (Wayland, MA); Boyd L. Harrison (Princeton Junction, NJ); Albert Jean Robichaud (Ringoes, NJ); Francesco G. Salituro (Marlborough, MA); Richard Thomas Beresis (Shanghai, CN)
Assignee: SAGE THERAPEUTICS, INC.
C07J5/0053A61K9/0019C07J3/00C07J7/00C07J15/00C07J43/003C07J1/007C07J1/0059C07J1/0074C07J5/0015C07J7/002C07J7/007C07J7/0085C07J13/007C07J21/00C07J31/006
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Quick Facts
Patent No.
US 9,512,165
App. No.
14/785,171
Granted
Dec 6, 2016
Kind
B2
Abstract

Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b , R 5 , R 6 , and R 7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Claims (4)

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of the formula:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Assignments (3)
CHANGE OF NAME Recorded May 13, 2026
From: SAGE THERAPEUTICS, INC.
To: SAGE THERAPEUTICS, LLC
Reel/Frame 075610/0448 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 28, 2018
From: BOTELLA, GABRIEL MARTINEZ; HARRISON, BOYD L.; ROBICHAUD, ALBERT JEAN; SALITURO, FRANCESCO G.; BERESIS, RICHARD THOMAS
To: SAGE THERAPEUTICS, INC.
Reel/Frame 046232/0850 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 7, 2016
From: MARTINEZ BOTELLA, GABRIEL; HARRISON, BOYD L.; ROBICHAUD, ALBERT JEAN; SALITURO, FRANCESCO G.; BERESIS, RICHARD THOMAS
To: SAGE THERAPEUTICS, INC.
Reel/Frame 039963/0689 →
Priority Claims (1)
WO PCT/CN2013/074323 · Apr 17, 2013 · international
Continuity (1)
Related Publication 20160108080A1 · Apr 21, 2016